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Diet Quality and Bone-Related Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 2035

Special Issue Editor


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Guest Editor
Department of Rehabilitation and Orthopaedics, Medical University of Lublin, 20-059 Lublin, Poland
Interests: bone; osteoporosis; nutrition; bone disease

Special Issue Information

Dear Colleagues,

Numerous laboratory and clinical studies indicate that correct diet and supplementation play important roles in human health. Extracted natural products may find application in the treatment of cancers and inflammatory conditions, and play an important role in the treatment of bone-related diseases. Due to the tremendous importance of prophylaxis, it is crucial for our food and supplements to contain the desired quantity of compounds that support metabolic pathways and processes. Dietary ingredients not only have nutritional value, but can also have additional advantages that manifest after consumption, changing the physiological or metabolic responses of the body or leading to a reduced occurrence of pathological processes.

For this Special Issue, we seek papers focused on mechanisms associated with the influence of alimentary administered substances that play important role in the bone homeostasis, prevention and treatment of bone related diseases. New insights into mechanisms related to bone metabolism, disease pathology and knowledge of molecular mechanisms provide an opportunity to present new methods in the prognosis, prevention, detection and treatment of bone-related diseases in this Special Issue.  

Prof. Dr. Tomasz Blicharski
Guest Editor

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Published Papers (1 paper)

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Research

19 pages, 3131 KiB  
Article
Fermented Rice Bran Supplementation Inhibits LPS-Induced Osteoclast Formation and Bone Resorption in Mice
by Takahiro Noguchi, Hideki Kitaura, Aseel Marahleh, Afifah Zahra Agista, Yusuke Ohsaki, Hitoshi Shirakawa and Itaru Mizoguchi
Nutrients 2023, 15(13), 3044; https://doi.org/10.3390/nu15133044 - 5 Jul 2023
Viewed by 1783
Abstract
Fermented rice bran (FRB) is known to have numerous beneficial bioactivities, amongst which is its anti-inflammatory properties when used as a supplement. To determine its effects, we examined osteoclastogenesis and bone resorption caused by injections of lipopolysaccharide (LPS), using mice with and without [...] Read more.
Fermented rice bran (FRB) is known to have numerous beneficial bioactivities, amongst which is its anti-inflammatory properties when used as a supplement. To determine its effects, we examined osteoclastogenesis and bone resorption caused by injections of lipopolysaccharide (LPS), using mice with and without FRB supplementation. The results were favorable: those that received FRB showed reduced osteoclast numbers and bone resorption compared to those with the control diet. Notably, receptor activator of NF-κB ligand (RANKL) and tumor necrosis factor-α (TNF-α) mRNA levels were shown to be lower in the LPS-treated animals with FRB supplementation. FRB’s inhibitory effect on RANKL- and TNF-α-induced osteoclastogenesis was further confirmed in vitro. In culture, macrophages exhibited decreased TNF-α mRNA levels when treated with FRB extract and LPS versus treatment with LPS alone, but there was no significant change in RANKL levels in osteoblasts. We can conclude that FRB supplementation dampens the effect of LPS-induced osteoclastogenesis and bone resorption by controlling TNF-α expression in macrophages and the direct inhibition of osteoclast formation. Full article
(This article belongs to the Special Issue Diet Quality and Bone-Related Diseases)
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