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Nutrients
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Association between Diet and Oxidative Stress
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Association between Diet and Oxidative Stress

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (15 June 2024) | Viewed by 1537

Special Issue Editors

Prof. Dr. Antoni Pons

E-Mail Website
Guest Editor
1. Research Group in Community Nutrition and Oxidative Stress, University of the Balearic Islands-IUNICS, 07122 Palma, Spain
2. Health Research Institute of Balearic Islands (IdISBa), 07120 Palma, Spain
3. CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Interests: oxidative stress; inflammation; nitric oxide; oxylipins; exercise; metabolic syndrome;
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Enrique Roche

E-Mail Website
Guest Editor
Área de Nutrición y Bromatología, Instituto de Bioingeniería, Universidad Miguel Hernández, Elche, Spain
Interests: functional foods; oxidative stress; sport recovery; supplements
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Oxidative stress is caused by an imbalance between the amount of reactive oxygen species present and the body’s antioxidant capacity. Strenuous endurance and resistance exercises increase the production of reactive oxygen compounds, resulting in oxidative stress, which has been associated with chronic diseases (diabetes, eye diseases, heart disease, cancer, kidney diseases, respiratory diseases, etc.).  Free radicals cause alterations in lipids, proteins, fatty acids, and nucleic acids, leading to cell death by apoptosis.

Diet plays a crucial role in this oxidant/antioxidant balance. Indeed, dietary nutrients can influence individuals’ total antioxidant capacity, modulating the degree of oxidative stress and affecting the incidence of diseases related to oxidation.

This Special Issue aims to collect recent information on how nutritional habits, diet interventions, and specific nutrients can reduce the harmful effect of oxidative stress.

Prof. Dr. Antoni Pons
Prof. Dr. Enrique  Roche
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • oxidative stress
  • exercise
  • chronic diseases
  • diabetes
  • diet
  • nutritional habits

Published Papers (2 papers)

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Research

19 pages, 1729 KiB  
Article
A Diet Lacking Selenium, but Not Zinc, Copper or Manganese, Induces Anticancer Activity in Mice with Metastatic Cancers
by Patricia Díaz-Ortega, José Manuel Calderón-Montaño, Julio José Jiménez-Alonso, Emilio Guillén-Mancina, Víctor Jiménez-González, Estefanía Burgos-Morón and Miguel López-Lázaro
Nutrients 2024, 16(14), 2249; https://doi.org/10.3390/nu16142249 - 12 Jul 2024
Viewed by 699
Abstract
Selenium, zinc, copper, and manganese are essential components of antioxidant enzymes involved in the elimination of reactive oxygen species (ROS). Given that cancer cells produce high levels of ROS and the accumulation of ROS can lead to cell death, cancer cells may be [...] Read more.
Selenium, zinc, copper, and manganese are essential components of antioxidant enzymes involved in the elimination of reactive oxygen species (ROS). Given that cancer cells produce high levels of ROS and the accumulation of ROS can lead to cell death, cancer cells may be susceptible to strategies that reduce ROS elimination. In this work, we prepared several artificial diets that contained normal carbohydrate, protein, and lipid levels but lacked selenium, zinc, copper, or manganese. The anticancer activity of these diets was examined in a metastatic ovarian cancer model, established by injecting ID8 Trp53−/− murine ovarian cancer cells into the peritoneal cavity of C57BL/6JRj mice. Treatments started 15 days later and consisted of replacing a normal diet with one of the artificial diets for several weeks. A significant improvement in mice survival was observed when the normal diet was replaced with the selenium-free diet. Diets lacking zinc, copper, or manganese showed no significant impact on mice survival. All diets were very well tolerated. The anticancer efficacy of a diet lacking selenium was confirmed in mice with metastatic colon cancer and in mice with metastatic triple-negative breast cancer. These results suggest that diets lacking selenium hold potential for the treatment of metastatic cancers. Full article
(This article belongs to the Special Issue Association between Diet and Oxidative Stress)
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19 pages, 3220 KiB  
Article
Exploring the Impact of French Raw-Milk Cheeses on Oxidative Process Using Caenorhabditis elegans and Human Leukocyte Models
by Anna Diet, Christophe Poix, Muriel Bonnet, Christian Coelho, Isabelle Ripoche, Caroline Decombat, Julien Priam, Etienne Saunier, Pierre Chalard, Stéphanie Bornes, Florence Caldefie-Chezet and Laurent Rios
Nutrients 2024, 16(12), 1862; https://doi.org/10.3390/nu16121862 - 13 Jun 2024
Viewed by 547
Abstract
Fermented foods, including cheeses, have garnered increased interest in recent years for their potential health benefits. This study explores the biological properties of eight French raw-milk cheeses—goat cheese, Saint-Nectaire, Cantal, Bleu d’Auvergne, Roquefort, Comté, Brie de Meaux, and Epoisses—on oxidative processes using both [...] Read more.
Fermented foods, including cheeses, have garnered increased interest in recent years for their potential health benefits. This study explores the biological properties of eight French raw-milk cheeses—goat cheese, Saint-Nectaire, Cantal, Bleu d’Auvergne, Roquefort, Comté, Brie de Meaux, and Epoisses—on oxidative processes using both in vivo (Caenorhabditis elegans) and in vitro (human leukocytes) models. A cheese fractionation protocol was adapted to study four fractions for each cheese: a freeze-dried fraction (FDC) corresponding to whole cheese, an apolar (ApE), and two polar extracts (W40 and W70). We showed that all cheese fractions significantly improved Caenorhabditis elegans (C. elegans) survival rates when exposed to oxidative conditions by up to five times compared to the control, regardless of the fractionation protocol and the cheese type. They were also all able to reduce the in vivo accumulation of reactive oxygen species (ROS) by up to 70% under oxidative conditions, thereby safeguarding C. elegans from oxidative damage. These beneficial effects were explained by a reduction in ROS production up to 50% in vitro in human leukocytes and overexpression of antioxidant factor-encoding genes (daf-16, skn-1, ctl-2, and sod-3) in C. elegans. Full article
(This article belongs to the Special Issue Association between Diet and Oxidative Stress)
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