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The Effects of Diet on Inflammation, Cardiovascular Risk and Metabolic Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: 25 September 2024 | Viewed by 1142

Special Issue Editor


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Guest Editor
Insitute of Clinical Physiology, National Research Council (IFC-CNR), 56124 Pisa, Italy
Interests: functional food in cardioprotection; relationship between nutrition and cardiovascular disease; preclinical models; cardiometabolic risk; atherosclerotic vascular disease; cardiovascular disease; obesity; mitochondrial damage; cardio-oncology

Special Issue Information

Dear Colleagues,

Maintaining a healthy body requires proper nutrition; however, in recent years, it has become increasingly apparent that many people consume excessive amounts of unhealthy nutrients, such as saturated fats and refined carbohydrates. This dietary habit can increase the risk of chronic cardiometabolic diseases, impair glucose regulation and lipid metabolism, and lead to obesity as well as diabetes. There is established evidence of the adverse effects of saturated fats on atherosclerosis, and it is now emerging that refined carbohydrates with a high glycemic index are the main contributors to the obesity pandemic. Furthermore, these unhealthy nutrients can harm the immune system and cause inflammation. On the other hand, balanced nutritional regimens like the Mediterranean diet have been shown to reduce or modify cardiometabolic risk factors, regulate the delicate balance of pro-inflammatory as well as anti-inflammatory mediators, and restore the immune system's ability to fight pathogens. Additionally, dietary supplements or nutraceuticals may be interesting since they can benefit gut-microbiome-related immunity.

This Special Issue aims to evaluate the progress made in understanding the mechanisms of action of individual nutrients or dietary patterns and the pathways involved in their impact on cardiovascular risk, chronic inflammation, and metabolic syndrome. These advancements would contribute to the prevention and treatment of chronic diseases. We invite research papers and up-to-date review articles on topics related to population-based studies or animal models. These may include, but are not limited to, the interaction of diet/nutrients and genetics in disease development and progression, therapeutic approaches based on dietary/nutraceutical supplements, and the relationship between dietary compounds and gut-microbiota-derived metabolites in impacting cardiometabolic and inflammatory diseases.

I look forward to receiving your contributions.

Dr. Claudia Kusmic
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet
  • cardiovascular risk factor
  • obesity
  • inflammatory disease
  • microbiota metabolites

Published Papers (1 paper)

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Review

20 pages, 1133 KiB  
Review
The Protective Effect of Flavonoids in the Diet on Autophagy-Related Cardiac Impairment
by Serena L’Abbate and Claudia Kusmic
Nutrients 2024, 16(14), 2207; https://doi.org/10.3390/nu16142207 - 10 Jul 2024
Viewed by 855
Abstract
The compounds known as flavonoids, commonly found in fruits, vegetables, legumes, medicinal herbs, chocolate, and coffee and tea beverages, have been extensively researched for their impact on cardiovascular health. Flavonoids, with their demonstrated potential, have shown promising effects in regulating blood vessel function [...] Read more.
The compounds known as flavonoids, commonly found in fruits, vegetables, legumes, medicinal herbs, chocolate, and coffee and tea beverages, have been extensively researched for their impact on cardiovascular health. Flavonoids, with their demonstrated potential, have shown promising effects in regulating blood vessel function and apoptotic processes, as well as in improving lipid profiles. While their powerful antioxidant properties were initially thought to be the main reason behind these effects, recent studies have uncovered new insights into the positive effects of flavonoids on cardiovascular health, and researchers have now identified several signaling pathways and mechanisms that also play a role. Of particular interest are the studies that have highlighted the role of autophagy in maintaining the physiological functions of cardiomyocytes and protecting them from harm. Recent publications have linked the dysregulation of autophagic processes with the development of cardiomyopathies, heart failure, and other cardiovascular diseases. This review aims to present the latest, novel findings from preclinical research regarding the potential beneficial effects of flavonoids on various heart conditions associated with altered autophagy processes. Full article
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