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Early Life Nutrition and Tissue Development

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Public Health".

Deadline for manuscript submissions: 5 March 2025 | Viewed by 285

Special Issue Editor


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Guest Editor
Arkansas Children’s Nutrition Center, University of Arkansas for Medical Sciences, Little Rock, AR, USA
Interests: maternal and postanal early life nutrition; bone development; gestational; lactational and pediatric bone loss; dietary factors; phenolic acids; epigenetics; DNA methylation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The first five years of life are the period when dietary behaviors that promote optimal nutrition, growth, and development are established or begin to be tracked throughout the lifespan. The mother’s nutritional status in the embryonic and fetal stages and the child’s nutritional status in infancy and early childhood can significantly affect child development and health.

During these sensitive developmental periods, disturbances in nutritional quality increase the risk of common adult diseases, such as obesity, metabolic syndrome, osteopenia, cardiovascular disease, non-alcoholic fatty liver disease, cognitive function, and neuropsychological disorders. Therefore, early life nutrition planning has become a hot research topic.

This Special Issue calls for original research or review articles focusing on how early life nutrition affects tissue development, growth, and function in children. Early exposure to phytonutrients (e.g., from blueberries or soy), or breastfeeding versus formula feeding, will be considered in both animal models and human cohorts. Manuscripts on the mechanisms by which obesity and high-fat diets (in mothers and their offspring) may contribute to poor bone health are also welcome.

Dr. Jin-Ran Chen
Guest Editor

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Keywords

  • early life nutrition
  • dietary behaviors
  • development
  • growth
  • breastfeeding

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Published Papers (1 paper)

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Research

23 pages, 1008 KiB  
Article
Investigation of Relationships between Intakes of Human Milk Total Lipids and Metabolic Hormones and Infant Sex and Body Composition
by Majed A. Suwaydi, Ching Tat Lai, Ashleigh H. Warden, Sharon L. Perrella, Jacki L. McEachran, Mary E. Wlodek, Donna T. Geddes and Zoya Gridneva
Nutrients 2024, 16(16), 2739; https://doi.org/10.3390/nu16162739 (registering DOI) - 16 Aug 2024
Abstract
Human milk (HM) composition, including metabolic hormones and lipids, is influenced by various factors, including lactation stage and, potentially, infant sex, which may affect infant body composition (BC) development. We aimed to: (a) characterize the longitudinal concentration and intake profiles of HM leptin, [...] Read more.
Human milk (HM) composition, including metabolic hormones and lipids, is influenced by various factors, including lactation stage and, potentially, infant sex, which may affect infant body composition (BC) development. We aimed to: (a) characterize the longitudinal concentration and intake profiles of HM leptin, adiponectin, insulin, and total lipids; (b) determine if their concentrations and intakes differ by infant sex; and (c) explore the intakes relationships with the development of infant BC. Milk samples (n = 501) were collected from 82 mother–infant dyads during the first 6 months postpartum. Infant 24 h HM intake was measured, and the average cumulative HM component intakes were calculated. The statistical analysis used linear mixed modeling. Intakes of HM leptin, adiponectin, insulin, and total lipids increased to 1 month postpartum and then remained stable. HM intake and total lipids intake but not hormone intake were positively associated with infant BC (fat-free mass, fat-free mass index, fat mass, fat mass index, percentage fat mass, and fat mass to fat-free mass ratio). HM component concentrations and intakes did not differ by sex. These findings advance our understanding of the temporal nature of HM components, emphasizing the role of infant 24 h HM and total lipids intake in development of infant lean and adipose tissue. Full article
(This article belongs to the Special Issue Early Life Nutrition and Tissue Development)
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