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Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and...
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Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and Diseases

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Lipids".

Deadline for manuscript submissions: 25 July 2024 | Viewed by 8931

Special Issue Editors

Dr. Tongxing Song

E-Mail Website
Guest Editor
College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China
Interests: stem cell fate; adipogenesis; lipid droplet; lipid metabolism; organs crosstalk
Dr. Zhihao Jia

E-Mail Website
Guest Editor
Cambridge-Suda Genomic Resource Center, Soochow University, Suzhou 215123, China
Interests: adipocytes; lipid metabolism; protein modification; thermogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Lipid metabolism includes the biosynthesis and degradation of lipids such as fatty acids, triglycerides and cholesterol. Dietary lipids are transported by specialized lipoproteins from the gut to the liver and finally accumulate in adipose tissue. However, excess systemic FFAs and dietary lipids enter inside the cells of non-adipose organs such as the liver, muscle, pancreas and placenta, and are deposited as ectopic fat, generating lipotoxicity. Dietary fat also can function as signal molecules by activating the downstream intracellular signaling pathways to regulate the function of adipose tissue and whole body homeostatsis.

Hence, the goal of this Special Issue, “Dietary lipid, adipose tissue and lipid metabolism in health and diseases”, is to focus on the importance of Lipid metabolism to human disease and health. This Special Issue aims to encourage authors to submit original research articles and review papers related to adipose tissue development and lipid metabolism in human health and diseases as well as related animal models. Specifically, the aim is to clarify the regulatory function of main tissues and organs, including the intestine, liver, adipose tissue, muscle, pancreas and placenta in whole-body homeostasis either directly via metabolic control or indirectly through multiple secreted factors. This new information will provide health care professionals with widespread, clear and updated evidence on the important role of lipid metabolism in human diseases and health.

This Research topics include but are not limited to the following:

  1. Dietary lipid in regulating lipid metabolism and health;
  2. Natural nutrients (products) in human health and diseases by lipid metabolism;
  3. New mechanism on adipose tissue development;
  4. Endocrinal role of adipose tissue in diseases;
  5. Crosstalk between adipose tissue and other organs and its contribution to metabolic homeostasis;
  6. Evidence from clinical data to provide a new perspective in regulating metabolic homeostasis;
  7. Nutritional interventions by dietary lipid for human health and diseases.

Dr. Tongxing Song
Dr. Zhihao Jia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lipid metabolism
  • adipose tissue
  • metabolic diseases
  • human health
  • natural products

Published Papers (5 papers)

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Research

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15 pages, 298 KiB  
Article
Fatty Acid Profile of Erythrocyte Membranes in Patients with Psoriasis
by Mariola Marchlewicz, Zofia Polakowska, Dominika Maciejewska-Markiewicz, Ewa Stachowska, Natalia Jakubiak, Magdalena Kiedrowicz, Aleksandra Rak-Załuska, Michał Duchnik, Alicja Wajs-Syrenicz and Ewa Duchnik
Nutrients 2024, 16(12), 1799; https://doi.org/10.3390/nu16121799 - 7 Jun 2024
Viewed by 453
Abstract
Psoriasis is a chronic systemic disease with a multifaceted pathomechanism and immunological basis, with the presence of inflammatory skin lesions and joint ailments. Diseases accompanying psoriasis include metabolic and cardiovascular disorders. It has been suggested that inflammation is involved in the development of [...] Read more.
Psoriasis is a chronic systemic disease with a multifaceted pathomechanism and immunological basis, with the presence of inflammatory skin lesions and joint ailments. Diseases accompanying psoriasis include metabolic and cardiovascular disorders. It has been suggested that inflammation is involved in the development of each of these conditions. The main objective of this study was to analyse the fatty acid profile, including polyunsaturated fatty acids, in the erythrocyte membranes of patients suffering from psoriasis. A total of 58 adult patients of the Department of Skin and Venereal Diseases of the Pomeranian Medical University in Szczecin, suffering from psoriasis, were qualified for this study. The patients had undergone an interview and physical examination, during which the severity of psoriasis was assessed. All patients had their weight and height measured to assess their body mass index (BMI). After 3 months of treatment, biochemical parameters (ALT, AST, total cholesterol) and inflammatory markers (CRP) in the blood were assessed. In addition, the isolation of fatty acids (PUFAs, SFAs, MUFAs) from erythrocyte membranes and the qualitative and quantitative analysis of their profile using a gas chromatograph were carried out. In patients with severe psoriasis requiring systemic treatment, an altered profile of fatty acids in erythrocyte membranes was found, including a significantly lower concentration of polyunsaturated fatty acids (omega-3), which have an anti-inflammatory effect; a significantly higher concentration of saturated fatty acids; and a decreased concentration of oleic acid (omega-9), compared to the results obtained in patients with less severe psoriasis receiving topical treatment. In patients with psoriasis and BMI ≥ 25, significantly higher concentrations of AST and ALT in the blood and significantly higher concentrations of pro-inflammatory arachidonic acid in erythrocyte membranes were found. Elevated concentrations of saturated (R = 0.31) and monounsaturated fatty acids (R = 0.29) may correlate with a greater severity of psoriasis. Full article
(This article belongs to the Special Issue Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and Diseases)
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14 pages, 4614 KiB  
Article
The Role of Proton-Coupled Amino Acid Transporter 2 (SLC36A2) in Cold-Induced Thermogenesis of Mice
by Hui Shu, Jie Zhang, Dawei Cheng, Xiaorui Zhao, Yue Ma, Chi Zhang, Yong Zhang, Zhihao Jia and Zhiwei Liu
Nutrients 2023, 15(16), 3552; https://doi.org/10.3390/nu15163552 - 11 Aug 2023
Viewed by 1134
Abstract
Brown adipocytes mainly utilize glucose and fatty acids to produce energy, which play key roles in thermogenesis. Furthermore, brown adipocytes also utilize other substrates, such as amino acids, for energy expenditure in various conditions. Here, we report the new physiological roles of proton-coupled [...] Read more.
Brown adipocytes mainly utilize glucose and fatty acids to produce energy, which play key roles in thermogenesis. Furthermore, brown adipocytes also utilize other substrates, such as amino acids, for energy expenditure in various conditions. Here, we report the new physiological roles of proton-coupled amino acid transporters, SLC36A2 and SLC36A3, on global energy metabolism. The relative mRNA expression levels of both Slc36a2 and Slc36a3 were all highest in brown adipose tissue. We then generated global Slc36a2 and Slc36a3 knockout mice to investigate their functions in metabolism. Neither loss of Slc36a2 nor Slc36a3 affected the body weight and body composition of the mice. Slc36a2 knockout mice exhibited increased oxygen consumption during the daytime. After cold treatment, inhibition of Slc36a2 significantly decreased the mass of brown adipose tissue compared to wildtype mice, while it lowered the expression level of Cpt1a. Moreover, the serum lipid levels and liver mass were also decreased in Slc36a2 knockout mice after cold treatment. On the contrary, Slc36a3 knockout impaired glucose tolerance and up-regulated serum LDL-cholesterol concentration. Thus, SLC36A2 and SLC36A3 play central and different roles in the energy metabolism of the mice. Full article
(This article belongs to the Special Issue Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and Diseases)
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12 pages, 1561 KiB  
Article
The Association between Circulating Lipids and Female Infertility Risk: A Univariable and Multivariable Mendelian Randomization Analysis
by Xiaoqi Zhu, Xiang Hong, Jingying Wu, Fanqi Zhao, Wei Wang, Lingling Huang, Jiuming Li and Bei Wang
Nutrients 2023, 15(14), 3130; https://doi.org/10.3390/nu15143130 - 13 Jul 2023
Cited by 4 | Viewed by 2296
Abstract
Background: Although observational studies have demonstrated that blood lipids are associated with female infertility, the causality of this association remains unclear. We performed a univariable and multivariable Mendelian randomization (MR) analysis to evaluate the causal relationship between blood lipids and female infertility. Methods: [...] Read more.
Background: Although observational studies have demonstrated that blood lipids are associated with female infertility, the causality of this association remains unclear. We performed a univariable and multivariable Mendelian randomization (MR) analysis to evaluate the causal relationship between blood lipids and female infertility. Methods: Single-nucleotide polymorphisms associated with lipid traits in univariate analysis were obtained from the Million Veteran Program (MVP) and Global Lipids Genetics Consortium (GLGC), involving up to 215,551 and 188,577 European individuals, respectively. Blood lipids in multivariate analysis were obtained from the latest genome-wide association study meta-analysis with lipid levels in 73 studies encompassing >300,000 participants. Data on female infertility were obtained from the FinnGen Consortium R6 release, which included 6481 samples and 75,450 controls. Subsequently, MR analysis was performed using inverse variance-weighted (IVW), weighted median, weighted-mode, simple-mode and MR-Egger regression to demonstrate the causal relationship between lipids and female infertility. Results: After controlling confounding factors including body mass index and age at menarche, two-sample MR demonstrated that genetically predicted LDL-C and TC were causally associated with the risk of female infertility (When the genetic instruments come from the MVP database, LDL-C and female infertility, IVW OR: 1.13, 95% CI: 1.001–1.269, p = 0.047; TC and female infertility, IVW OR: 1.16, 95% CI: 1.018–1.317, p = 0.025, and when the genetic instruments came from the GLGC database, LDL-C and female infertility, IVW OR: 1.10, 95% CI: 1.008–1.210, p = 0.033; TC and female infertility, IVW OR: 1.14, 95% CI: 1.024–1.258, p = 0.015). However, the IVW estimate showed that HDL-C was not significantly associated with the risk of female infertility (when the genetic instruments came from the MVP database, IVW OR: 1.00, 95% CI: 0.887–1.128, p = 0.999; when the genetic instruments came from the GLGC database, IVW OR: 1.00, 95% CI: 0.896–1.111, p = 0.968). The multivariable MR analysis also provided evidence that LDL-C (OR: 1.12, 95% CI: 1.006–1.243, p = 0.042) was significantly associated with the risk of female infertility after considering the correlation of all lipid-related traits. Conclusion: These findings support a causal relationship between increased LDL-cholesterol and increased female infertility risk. Furthermore, the association between lipid-related traits and female infertility risk merits more studies. Full article
(This article belongs to the Special Issue Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and Diseases)
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Review

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15 pages, 1061 KiB  
Review
Nuclear Receptor PPARα as a Therapeutic Target in Diseases Associated with Lipid Metabolism Disorders
by Ping Hu, Kaiqi Li, Xiaoxu Peng, Yufei Kan, Hao Li, Yanli Zhu, Ziyu Wang, Zhaojian Li, Hao-Yu Liu and Demin Cai
Nutrients 2023, 15(22), 4772; https://doi.org/10.3390/nu15224772 - 13 Nov 2023
Cited by 4 | Viewed by 1755
Abstract
Lipid metabolic diseases have substantial morbidity and mortality rates, posing a significant threat to human health. PPARα, a member of the peroxisome proliferator-activated receptors (PPARs), plays a crucial role in lipid metabolism and immune regulation. Recent studies have increasingly recognized the pivotal involvement [...] Read more.
Lipid metabolic diseases have substantial morbidity and mortality rates, posing a significant threat to human health. PPARα, a member of the peroxisome proliferator-activated receptors (PPARs), plays a crucial role in lipid metabolism and immune regulation. Recent studies have increasingly recognized the pivotal involvement of PPARα in diverse pathological conditions. This comprehensive review aims to elucidate the multifaceted role of PPARα in metabolic diseases including liver diseases, diabetes-related diseases, age-related diseases, and cancers, shedding light on the underlying molecular mechanisms and some regulatory effects of natural/synthetic ligands of PPARα. By summarizing the latest research findings on PPARα, we aim to provide a foundation for the possible therapeutic exploitation of PPARα in lipid metabolic diseases. Full article
(This article belongs to the Special Issue Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and Diseases)
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24 pages, 1136 KiB  
Review
Alcohol, White Adipose Tissue, and Brown Adipose Tissue: Mechanistic Links to Lipogenesis and Lipolysis
by Qing Li, Ou Wang, Baoping Ji, Liang Zhao and Lei Zhao
Nutrients 2023, 15(13), 2953; https://doi.org/10.3390/nu15132953 - 29 Jun 2023
Cited by 4 | Viewed by 2611
Abstract
According to data from the World Health Organization, there were about 3 million deaths caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver disease. Alcohol consumption interfering with the normal function of adipocytes has an important impact [...] Read more.
According to data from the World Health Organization, there were about 3 million deaths caused by alcohol consumption worldwide in 2016, of which about 50% were related to liver disease. Alcohol consumption interfering with the normal function of adipocytes has an important impact on the pathogenesis of alcoholic liver disease. There has been increasing recognition of the crucial role of adipose tissue in regulating systemic metabolism, far beyond that of an inert energy storage organ in recent years. The endocrine function of adipose tissue is widely recognized, and the significance of the proteins it produces and releases is still being investigated. Alcohol consumption may affect white adipose tissue (WAT) and brown adipose tissue (BAT), which interact with surrounding tissues such as the liver and intestines. This review briefly introduces the basic concept and classification of adipose tissue and summarizes the mechanism of alcohol affecting lipolysis and lipogenesis in WAT and BAT. The adipose tissue–liver axis is crucial in maintaining lipid homeostasis within the body. Therefore, this review also demonstrates the effects of alcohol consumption on the adipose tissue–liver axis to explore the role of alcohol consumption in the crosstalk between adipose tissue and the liver. Full article
(This article belongs to the Special Issue Dietary Lipid, Adipose Tissue and Lipid Metabolism in Health and Diseases)
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