Iron Dysregulation and the Role of Iron in Disease Pathogenesis
A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Micronutrients and Human Health".
Deadline for manuscript submissions: closed (5 March 2024) | Viewed by 4465
Special Issue Editor
Special Issue Information
Dear Colleagues,
Biometals such as iron (Fe) are trace elements vital to many human processes. They are often referred to as micronutrients as they are needed in small amounts (less than 100 mg/day for an adult).
Iron is an essential nutrient that is used in multiple normal cell functions. Haemoglobin contains about 70% of the body’s iron, while the remaining 30% is mainly stored in macrophages and hepatocytes. Non-heme bound iron is transported into cells via transferrin (Tf), which is endocytosed by Tf receptor (TfR)-1. Non-Tf bound iron (NTBI) is reduced to its ferrous state (Fe2+) by a cell-surface reductase (duodenal cytochrome b (Dcytb)). Within the endosome, ferric iron is oxidised back to Fe2+ and transported across the endosomal membrane by divalent metal transporter 1 (DMT1). Cytosolic iron is either stored in ferritin, used for metabolism, or released back into the extracellular space via the only known iron exporter, ferroportin. Hepcidin, a small liver-derived peptide hormone, functions as the principal regulator of iron absorption and homeostasis in the body. In disease states of iron overload and increased inflammation, hepcidin inhibits iron absorption and recycling by binding to ferroportin.
Iron dysregulation and iron-induced cell death have been implicated in several disease processes, and we believe there is still a lot of exciting work to be done in discovering how iron is involved in disease and how it can be therapeutically targeted.
As the Guest Editor of the Special Issue ‘Iron Dysregulation and the Role of Iron in Disease Pathogenesis’, I invite you to submit a manuscript to Nutrients, one of the most-read and cited research journals in the category “Nutrition and Metabolism”. The objective of this Special Issue is to bring together researchers in the fields of iron metabolism, chronic disease pathogenesis and therapeutics to further understand the role of iron in disease, including cancer, neurodegenerative disorders, preganacy and chronic airway diseases.
Dr. Ama-Tawiah Essilfie
Guest Editor
Manuscript Submission Information
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Keywords
- iron
- disease pathogenesis
- iron dysregulation
- ferroptosis
- therapeutics
- cancer
- airway diseases
