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Mechanisms of Beneficial Action of Phytochemicals in Alzheimer’s Disease

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Phytochemicals and Human Health".

Deadline for manuscript submissions: closed (15 July 2024) | Viewed by 4149

Special Issue Editor


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Guest Editor
Applied Biology and Food Sciences, Faculty of Agriculture and Life Science, Hirosaki University, 3 Bunkyo-cho, Hirosaki, Aomori 036-8561, Japan
Interests: Alzheimer's disease; aging; memory; behavior; polyphenols

Special Issue Information

Dear Colleagues,

Alzheimer’s disease (AD), which is characterized by the presence of amyloid plaques and neurofibrillary tangles accompanied by neurodegeneration, is the most common form of dementia among the elderly. It is widely accepted that phytochemicals exert a wide range of beneficial effects against the pathological features of AD, such as amyloid beta pathology, hyperphosphorylation of tau, and oxidative stress. The objective of this Special Issue is to collect recent findings regarding the mechanisms of beneficial action of phytochemicals and phytochemical-rich plant extracts against AD. We encourage the submission of original research studies in in vitro cell culture models and in vivo animal models of AD. Review articles are also welcome.

Prof. Dr. Akira Nakajima
Guest Editor

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Keywords

  • Alzheimer’s disease
  • amyloid beta
  • phytochemicals
  • hyperphosphorylation of tau
  • oxidative stress
  • neuroinflammation
  • neurodegeneration
  • memory impairment

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Published Papers (2 papers)

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Research

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13 pages, 2064 KiB  
Article
Apple Pomace Extract Improves MK-801-Induced Memory Impairment in Mice
by Ayako Watanabe, Minori Shimada, Hayato Maeda, Tsuyoshi Narumi, Junji Ichita, Koh Itoku and Akira Nakajima
Nutrients 2024, 16(2), 194; https://doi.org/10.3390/nu16020194 - 6 Jan 2024
Cited by 3 | Viewed by 1824
Abstract
Alzheimer’s disease (AD) is a neurodegenerative disease that involves progressive cognitive decline accompanied by synaptic degeneration and impaired neurotransmission. Recent studies revealed that apple pomace, a waste byproduct of the apple processing industry, has beneficial health properties, but its potential to prevent and [...] Read more.
Alzheimer’s disease (AD) is a neurodegenerative disease that involves progressive cognitive decline accompanied by synaptic degeneration and impaired neurotransmission. Recent studies revealed that apple pomace, a waste byproduct of the apple processing industry, has beneficial health properties, but its potential to prevent and treat AD has not been determined. Herein, we examined the effects of apple pomace extract on N-methyl-D-aspartate receptor antagonist MK-801-induced memory impairment in mice. Repeated treatment with apple pomace extract for 7 days reversed the MK-801-induced impairment of associative memory and recognition memory. RNA sequencing revealed that repeated treatment with apple pomace extract altered the gene expression profile in the hippocampus of mice. Real-time PCR showed that apple pomace extract induced upregulation of the mRNA expression for Zfp125 and Gstp1. Furthermore, gene sets related to synapse and neurotransmission were upregulated by apple pomace extract. These findings indicate that apple pomace extract may be useful for the prevention and treatment of AD. Full article
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Review

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16 pages, 1324 KiB  
Review
Therapeutic Effects of Plant Anthocyanin against Alzheimer’s Disease and Modulate Gut Health, Short-Chain Fatty Acids
by Al Borhan Bayazid and Beong Ou Lim
Nutrients 2024, 16(11), 1554; https://doi.org/10.3390/nu16111554 - 21 May 2024
Cited by 1 | Viewed by 1892
Abstract
Alzheimer’s disease (AD) is the most common form of dementia and neurogenerative disease (NDD), and it is also one of the leading causes of death worldwide. The number of AD patients is over 55 million according to 2020 Alzheimer’s Disease International (ADI), and [...] Read more.
Alzheimer’s disease (AD) is the most common form of dementia and neurogenerative disease (NDD), and it is also one of the leading causes of death worldwide. The number of AD patients is over 55 million according to 2020 Alzheimer’s Disease International (ADI), and the number is increasing drastically without any effective cure. In this review, we discuss and analyze the potential role of anthocyanins (ACNs) against AD while understanding the molecular mechanisms. ACNs have been reported as having neuroprotective effects by mitigating cognitive impairments, apoptotic markers, neuroinflammation, aberrant amyloidogenesis, and tauopathy. Taken together, ACNs could be an important therapeutic agent for combating or delaying the onset of AD. Full article
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