nutrients-logo

Journal Browser

Journal Browser

The Ketogenic Diet in the Management of Adult Neurological Disorders: Physiological Adaptation Mechanisms

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Clinical Nutrition".

Deadline for manuscript submissions: closed (25 August 2024) | Viewed by 1065

Special Issue Editors


E-Mail Website
Guest Editor
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Via del Vespro 129, 90127 Palermo, Italy
Interests: physiology of nutrition; controlled feeding studies; phytonutrients; relationships between dietary intake and physiological outcomes; malnourishment; metabolism; multiple sclerosis
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, 90134 Palermo, Italy
Interests: cognitive neuroscience; spatial cognition; neurolinguistics; cortical excitability; motor cortex; computational models; brain stimulation; TMS; tDCS

Special Issue Information

Dear Colleagues,

The ketogenic diet has been re-evaluated in recent years and has been proposed as an effective nonfarmacological intervention in several neurological conditions such as Alzheimer's, Parkinson's, and Multiple Sclerosis. As conventional therapies that are used to treat neurological disorders are increasingly associated with drug resistance and drug tolerance, nutritional therapy is becoming a useful adjunct for improving disease progression. However, to date, the complex relationship between the effects of the ketogenic diet and the pathophysiological mechanisms of neurodegereative and autoinflammatory neurological diseases,  as well as its clinical relevance, is still lacking strong evidence. The purpose of this Special Issue to provide an insight into the mechanisms of neuromodulation and neuroprotection that develop when a ketogenic diet regimen is applied and that can be considered to be improving the management of neurological disorders. Both mechanicistics and clinical interventional works, as well as reviews, are welcome.  The Special Issue will also focus on the nutrition–microbiome and neuroprotection axis to take stock of the qualitative and quantitative aspects of the ketogenic diet that cannot be overlooked when evaluating beneficial neurological effects.

Dr. Danila Di Majo
Dr. Giuseppe Giglia
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurological disease
  • ketogenic diet
  • microbiome
  • neuromodulation
  • neuroprotection

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

29 pages, 4245 KiB  
Article
Effects of Ketogenic Diet on Increased Ethanol Consumption Induced by Social Stress in Female Mice
by Laura Torres-Rubio, Marina D. Reguilón, Susana Mellado, María Pascual and Marta Rodríguez-Arias
Nutrients 2024, 16(17), 2814; https://doi.org/10.3390/nu16172814 - 23 Aug 2024
Viewed by 894
Abstract
Stress is a critical factor in the development of mental disorders such as addiction, underscoring the importance of stress resilience strategies. While the ketogenic diet (KD) has shown efficacy in reducing alcohol consumption in male mice without cognitive impairment, its impact on the [...] Read more.
Stress is a critical factor in the development of mental disorders such as addiction, underscoring the importance of stress resilience strategies. While the ketogenic diet (KD) has shown efficacy in reducing alcohol consumption in male mice without cognitive impairment, its impact on the stress response and addiction development, especially in females, remains unclear. This study examined the KD’s effect on increasing ethanol intake due to vicarious social defeat (VSD) in female mice. Sixty-four female OF1 mice were divided into two dietary groups: standard diet (n = 32) and KD (n = 32). These were further split based on exposure to four VSD or exploration sessions, creating four groups: EXP-STD (n = 16), VSD-STD (n = 16), EXP-KD (n = 16), and VSD-KD (n = 16). KD-fed mice maintained ketosis from adolescence until the fourth VSD/EXP session, after which they switched to a standard diet. The Social Interaction Test was performed 24 h after the last VSD session. Three weeks post-VSD, the Drinking in the Dark test and Oral Ethanol Self-Administration assessed ethanol consumption. The results showed that the KD blocked the increase in ethanol consumption induced by VSD in females. Moreover, among other changes, the KD increased the expression of the ADORA1 and CNR1 genes, which are associated with mechanisms modulating neurotransmission. Our results point to the KD as a useful tool to increase resilience to social stress in female mice. Full article
Show Figures

Figure 1

Back to TopTop