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Nutrients
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Biomarkers and Nutrients in Musculoskeletal Disorders
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Biomarkers and Nutrients in Musculoskeletal Disorders

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Sports Nutrition".

Deadline for manuscript submissions: closed (31 October 2020) | Viewed by 58235

Printed Edition Available!
A printed edition of this Special Issue is available here.

Special Issue Editors

Prof. Dr. César Calvo-Lobo

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Guest Editor
Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: ligaments; muscles; myofascial pain syndrome; musculoskeletal disorders; sports; tendons; ultrasonography
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ricardo Becerro de Bengoa Vallejo

E-Mail Website
Guest Editor
Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: feet; ligaments; muscles; musculoskeletal disorders; reliability; sports; tendons; ultrasonography; validation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marta Elena Losa-Iglesias

E-Mail Website
Guest Editor
Faculty of Health Sciences, Universidad Rey Juan Carlos, 28922 Alcorcón, Spain
Interests: health care; biomechanics; quality of life; shoes; pain; epidemiology; orthopedic; podiatry; prevention and promotion of the health; rehabilitation
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Marta San-Antolín

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Guest Editor
Department of Psychology, Universidad Europea de Madrid, Madrid, Spain
Interests: biomarkers; health care; nutrients; musculoskeletal disorders; sports; orthopedics; rheumatology
Prof. Dr. David Rodríguez Sanz

E-Mail Website
Guest Editor
Facultad de Enfermería, Fisioterapia y Podología, Universidad Complutense de Madrid, 28040 Madrid, Spain
Interests: feet; ligaments; muscles; musculoskeletal disorders; sports; tendons; ultrasonography
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Daniel López-López

E-Mail Website
Guest Editor
Research, Health and Podiatry Group, Department of Health Sciences, Faculty of Nursing and Podiatry, Universidade da Coruña, 150403 Ferrol, Spain
Interests: biomechanics; quality of life; shoes; pain; epidemiology; orthopedic; podiatry; prevention and promotion of the health; rehabilitation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Biomarkers and nutrients play a key role in the diagnosis, prognosis, and status of patients who suffer from musculoskeletal disorders. This MDPI Special Issue included in Nutrients and entitled “Biomarkers and Nutrients in Musculoskeletal Disorders” welcomes the submission of original research papers, including clinical trials, quasi-experimental studies, cross-sectional studies, cohort studies, case–control studies, basic sciences and diagnosis or reliability studies, as well as reviews or meta-analysis about current research literature on biomarkers and nutrients related to musculoskeletal disorders. The topics of interest are multidisciplinary, such as biomarkers, nutrients, nutrition, geriatrics, internal or sports medicine, rheumatology, orthopedics, physical therapy, and primary and specialized care related to musculoskeletal disorders. The Guest Editors encourage authors from a wide range of disciplines to submit their proposals.

Potential topics include, but are not limited to:

  • biomarkers
  • nutrients
  • nutrition
  • non-specific musculoskeletal disorders
  • sarcopenia and aging
  • osteoporosis
  • rheumatology
  • orthopedics and physical therapy
  • primary and specialized health care
  • sports health

Prof. Dr. Marta Elena Losa-Iglesias
Prof. Dr. Ricardo Becerro de Bengoa Vallejo
Prof. Dr. David Rodríguez Sanz
Prof. Dr. César Calvo-Lobo
Prof. Dr. Daniel López-López
Prof. Dr. Marta San-Antolín
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomarkers
  • health care
  • nutrients
  • musculoskeletal disorders
  • orthopedics
  • sports
  • rheumatology

Published Papers (7 papers)

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Editorial

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5 pages, 222 KiB  
Editorial
Biomarkers and Nutrients in Musculoskeletal Disorders
by César Calvo-Lobo, Ricardo Becerro-de-Bengoa-Vallejo, Marta Elena Losa-Iglesias, David Rodríguez-Sanz, Daniel López-López and Marta San-Antolín
Nutrients 2021, 13(2), 283; https://doi.org/10.3390/nu13020283 - 20 Jan 2021
Cited by 2 | Viewed by 2940
Abstract
Worldwide, the burden of musculoskeletal disorders is increasing with great variations between-countries, which makes it difficult for policymakers to provide resources and adequate interventions in order to provide for their appropriate management [...] Full article
(This article belongs to the Special Issue Biomarkers and Nutrients in Musculoskeletal Disorders)

Research

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13 pages, 2312 KiB  
Article
l-Cysteine and Vitamin D Co-Supplementation Alleviates Markers of Musculoskeletal Disorders in Vitamin D-Deficient High-Fat Diet-Fed Mice
by Rajesh Parsanathan, Arunkumar E. Achari, Prasenjit Manna and Sushil K. Jain
Nutrients 2020, 12(11), 3406; https://doi.org/10.3390/nu12113406 - 6 Nov 2020
Cited by 13 | Viewed by 2872
Abstract
Vitamin D (VD) deficiency is associated with musculoskeletal disorders. This study examines whether co-supplementation of l-cysteine (LC) and VD is better than monotherapy with LC or VD at alleviating musculoskeletal dyshomeostasis in the skeletal muscle of VD-deficient high-fat diet (HFD-VD-) fed mice. [...] Read more.
Vitamin D (VD) deficiency is associated with musculoskeletal disorders. This study examines whether co-supplementation of l-cysteine (LC) and VD is better than monotherapy with LC or VD at alleviating musculoskeletal dyshomeostasis in the skeletal muscle of VD-deficient high-fat diet (HFD-VD-) fed mice. Mice were fed a healthy diet or an HFD; for VD-deficient animals, the mice were maintained on a HFD-VD-diet (16 weeks); after the first 8 weeks, the HFD-VD-diet-fed mice were supplemented for another 8 weeks with LC, VD-alone, or the same doses of LC + VD by oral gavage. Saline and olive oil served as controls. Myotubes were exposed with high-glucose, palmitate, Monocyte Chemoattractant Protein 1 (MCP-1), and Tumor Necrosis Factor (TNF), to mimic the in vivo microenvironment. In vitro deficiencies of glutathione and hydrogen sulfide were induced by knockdown of GCLC and CSE genes. Relative gene expression of biomarkers (myogenic: MyoD, Mef2c, Csrp3; muscle dystrophy: Atrogin1, Murf1, and Myostatin; bone modeling and remodeling: RANK, RANKL, OPG) were analyzed using qRT-PCR. Co-supplementatoin with LC + VD showed beneficial effects on gene expression of myogenic markers and OPG but reduced markers of dystrophy, RANK/RANKL in comparison to LC or VD alone-supplementation. In vitro myotubes treated with glutathione (GSH) precursors also showed a positive effect on OPG and the myogenesis genes, and inhibited RANK/RANKL and muscle-dystrophy markers. This study reveals that the co-supplementation of LC with VD significantly alleviates the markers of musculoskeletal disorders in the skeletal muscle better than monotherapy with LC or VD in HFD-VD-fed mice. Full article
(This article belongs to the Special Issue Biomarkers and Nutrients in Musculoskeletal Disorders)
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13 pages, 2451 KiB  
Article
Effects of a Fat-Rich Diet on the Spontaneous Release of Acetylcholine in the Neuromuscular Junction of Mice
by Carlos Gimenez-Donoso, Marc Bosque, Anna Vila, Gemma Vilalta and Manel M Santafe
Nutrients 2020, 12(10), 3216; https://doi.org/10.3390/nu12103216 - 21 Oct 2020
Cited by 3 | Viewed by 6328
Abstract
Western societies are facing a clear increase in the rate of obesity and overweight which are responsible for musculoskeletal pain. Some of the substances described in the environment of myofascial trigger points (MTrPs) are the same as those found in the skeletal muscle [...] Read more.
Western societies are facing a clear increase in the rate of obesity and overweight which are responsible for musculoskeletal pain. Some of the substances described in the environment of myofascial trigger points (MTrPs) are the same as those found in the skeletal muscle of obese people, such as cytokines. Furthermore, elevated neuromuscular neurotransmission has been associated with MTrPs. The main objective of this study is to assess whether obesity or overweight may be a facilitator of myofascial pain. The experiments were performed on male Swiss mice. One experimental group was given a typical “cafeteria” diet and another group a commercial high-fat diet for six weeks. Intramuscular adipocytes were assessed with Sudan III. The functional study was performed with electromyographic recording to determine the plaque noise and intracellular recording of miniature endplate potentials (MEPPs). The intake of a cafeteria diet showed the presence of more adipocytes in muscle tissue, but not with the fat-supplemented diet. Both experimental groups showed an increase in the plaque noise and an increase in the frequency of MEPPs that lasted several weeks after interrupting diets. In summary, the supply of a hypercaloric diet for six weeks in mice increases spontaneous neurotransmission, thus facilitating the development of MTrPs. Full article
(This article belongs to the Special Issue Biomarkers and Nutrients in Musculoskeletal Disorders)
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24 pages, 3780 KiB  
Article
Satellite Cells and Markers of Muscle Regeneration during Unloading and Reloading: Effects of Treatment with Resveratrol and Curcumin
by Laura Mañas-García, Maria Guitart, Xavier Duran and Esther Barreiro
Nutrients 2020, 12(6), 1870; https://doi.org/10.3390/nu12061870 - 23 Jun 2020
Cited by 21 | Viewed by 4384
Abstract
We hypothesized that treatment with pharmacological agents known to increase sirtuin-1 activity (resveratrol and curcumin) may enhance muscle regeneration. In limb muscles of mice (C57BL/6J, 10 weeks) exposed to reloading for seven days following a seven-day period of hindlimb immobilization with/without curcumin or [...] Read more.
We hypothesized that treatment with pharmacological agents known to increase sirtuin-1 activity (resveratrol and curcumin) may enhance muscle regeneration. In limb muscles of mice (C57BL/6J, 10 weeks) exposed to reloading for seven days following a seven-day period of hindlimb immobilization with/without curcumin or resveratrol treatment, progenitor muscle cell numbers (FACS), satellite cell subtypes (histology), early and late muscle regeneration markers, phenotype and morphometry, sirtuin-1 activity and content, and muscle function were assessed. Treatment with either resveratrol or curcumin in immobilized muscles elicited a significant improvement in numbers of progenitor, activated, quiescent, and total counts of muscle satellite cells, compared to non-treated animals. Treatment with either resveratrol or curcumin in reloaded muscles compared to non-treated mice induced a significant improvement in the CSA of both hybrid (curcumin) and fast-twitch fibers (resveratrol), sirtuin-1 activity (curcumin), sirtuin-1 content (resveratrol), and counts of progenitor muscle cells (resveratrol). Treatment with the pharmacological agents resveratrol and curcumin enhanced the numbers of satellite cells (muscle progenitor, quiescent, activated, and total satellite cells) in the unloaded limb muscles but not in the reloaded muscles. These findings have potential clinical implications as treatment with these phenolic compounds would predominantly be indicated during disuse muscle atrophy to enhance the muscle regeneration process. Full article
(This article belongs to the Special Issue Biomarkers and Nutrients in Musculoskeletal Disorders)
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Review

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18 pages, 820 KiB  
Review
Metabolic and Nutritional Issues Associated with Spinal Muscular Atrophy
by Yang-Jean Li, Tai-Heng Chen, Yan-Zhang Wu and Yung-Hao Tseng
Nutrients 2020, 12(12), 3842; https://doi.org/10.3390/nu12123842 - 16 Dec 2020
Cited by 17 | Viewed by 8839
Abstract
Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a neurodegenerative disease characterized by the selective loss of motor neurons in the anterior horn of the spinal cord, accompanied by muscle wasting. Pathomechanically, SMA is caused by low levels of [...] Read more.
Spinal muscular atrophy (SMA), the main genetic cause of infant death, is a neurodegenerative disease characterized by the selective loss of motor neurons in the anterior horn of the spinal cord, accompanied by muscle wasting. Pathomechanically, SMA is caused by low levels of the survival motor neuron protein (SMN) resulting from the loss of the SMN1 gene. However, emerging research extends the pathogenic effect of SMN deficiency beyond motor neurons. A variety of metabolic abnormalities, especially altered fatty acid metabolism and impaired glucose tolerance, has been described in isolated cases of SMA; therefore, the impact of SMN deficiency in metabolic abnormalities has been speculated. Although the life expectancy of these patients has increased due to novel disease-modifying therapies and standardization of care, understanding of the involvement of metabolism and nutrition in SMA is still limited. Optimal nutrition support and metabolic monitoring are essential for patients with SMA, and a comprehensive nutritional assessment can guide personalized nutritional therapy for this vulnerable population. It has recently been suggested that metabolomics studies before and after the onset of SMA in patients can provide valuable information about the direct or indirect effects of SMN deficiency on metabolic abnormalities. Furthermore, identifying and quantifying the specific metabolites in SMA patients may serve as an authentic biomarker or therapeutic target for SMA. Here, we review the main epidemiological and mechanistic findings that link metabolic changes to SMA and further discuss the principles of metabolomics as a novel approach to seek biomarkers and therapeutic insights in SMA. Full article
(This article belongs to the Special Issue Biomarkers and Nutrients in Musculoskeletal Disorders)
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18 pages, 302 KiB  
Review
Nutrients in the Prevention of Osteoporosis in Patients with Inflammatory Bowel Diseases
by Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Zawada, Agnieszka Dobrowolska and Iwona Krela-Kaźmierczak
Nutrients 2020, 12(6), 1702; https://doi.org/10.3390/nu12061702 - 6 Jun 2020
Cited by 25 | Viewed by 5792
Abstract
The chronic character of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, results in various complications. One of them is osteoporosis, manifested by low bone mineral density, which leads to an increased risk of fractures. The aetiology of low bone mineral [...] Read more.
The chronic character of inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis, results in various complications. One of them is osteoporosis, manifested by low bone mineral density, which leads to an increased risk of fractures. The aetiology of low bone mineral density is multifactorial and includes both diet and nutritional status. Calcium and vitamin D are the most often discussed nutrients with regard to bone mineral density. Moreover, vitamins A, K, C, B12; folic acid; calcium; phosphorus; magnesium; sodium; zinc; copper; and selenium are also involved in the formation of bone mass. Patients suffering from inflammatory bowel diseases frequently consume inadequate amounts of the aforementioned minerals and vitamins or their absorption is disturbed, resulting innutritional deficiency and an increased risk of osteoporosis. Thus, nutritional guidelines for inflammatory bowel disease patients should comprise information concerning the prevention of osteoporosis. Full article
(This article belongs to the Special Issue Biomarkers and Nutrients in Musculoskeletal Disorders)
17 pages, 1168 KiB  
Review
Metabolic Impacts of Confinement during the COVID-19 Pandemic Due to Modified Diet and Physical Activity Habits
by María Martinez-Ferran, Fernando de la Guía-Galipienso, Fabián Sanchis-Gomar and Helios Pareja-Galeano
Nutrients 2020, 12(6), 1549; https://doi.org/10.3390/nu12061549 - 26 May 2020
Cited by 242 | Viewed by 26059
Abstract
While the detrimental effects of a chronic positive energy balance due to a sedentary lifestyle have been well established, the impacts of a short period of abruptly reduced physical activity and overeating arising from strict confinement due to the COVID-19 pandemic will soon [...] Read more.
While the detrimental effects of a chronic positive energy balance due to a sedentary lifestyle have been well established, the impacts of a short period of abruptly reduced physical activity and overeating arising from strict confinement due to the COVID-19 pandemic will soon start to emerge. To reasonably anticipate major consequences according to the available evidence, we hereby review the literature for studies that have explored the health impacts of several weeks of a reduction in physical activity and daily step-count combined with modified eating habits. These studies identify as main metabolic consequences increases in insulin resistance, total body fat, abdominal fat and inflammatory cytokines. All these factors have been strongly associated with the development of metabolic syndrome, which in turn increases the risk of multiple chronic diseases. A plausible mechanism involved in these impacts could be a positive energy balance promoted by maintaining usual dietary intake while reducing energy expenditure. This means that just as calorie intake restriction could help mitigate the deleterious impacts of a bout of physical inactivity, overeating under conditions of home confinement is very likely to exacerbate these consequences. Moreover, hypertension, diabetes, and cardiovascular disease have been identified as potential risk factors for more severely ill patients with COVID-19. Thus, adequate control of metabolic disorders could be important to reduce the risk of severe COVID-19. Full article
(This article belongs to the Special Issue Biomarkers and Nutrients in Musculoskeletal Disorders)
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