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Nutrients
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Cyclitols in Cardiometabolic Syndrome
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Cyclitols in Cardiometabolic Syndrome

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 2978

Special Issue Editors

Prof. Dr. Andrzej Rynkiewicz

E-Mail Website
Guest Editor
1st Department of Cardiology and Internal Medicine, School of Medicine, University of Warmia and Mazury in Olsztyn, 10-082 Olsztyn, Poland
Interests: coronary heart disease; heart failure; arterial hypertension; diabetes mellitus; cardiovascular epidemiology and prevention; nutrition; metabolomics; proteomics; genomics in cardiovascular disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Michal Majewski

E-Mail Website
Guest Editor
Department of Pharmacology and Toxicology, University of Warmia and Mazury in Olsztyn, Olsztyn WM, Poland
Interests: relationship between biologically active compounds and health status; nutritional interventions in reducing cardiovascular disorders; methods related to the analysis of inflammatory and antioxidant parameters; preparing and conducting nutritional experiments on rats (hypertensive, obese, and aged rats)
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Cyclitols are a group of plant-derived cycloalkanes, containing one hydroxyl group on each of three or more carbons in the ring. In recent years, accumulating evidence from animal and human studies suggested a wide range of pharmaceutical benefits of cyclitol supplementation. Among different compounds, the greatest attention was attracted to inositols, in particular myo-inositol and d-chiro-inositol. As key mediators of cell signal transduction, inositols play a major role in insulin signaling, cell growth, peripheral nerve function, and osteogenesis. In particular, the ability to increase insulin sensitivity was a reason for clinical trials evaluating the use of myo-insoitol and d-chiro-insoitol in polycystic ovary syndrome, type 2 diabetes, and obesity. Simultaneously to improvement in glucose metabolism, inositol supplementation may have a beneficial effect on a variety of metabolic factors, including blood lipids, blood pressure, weight status, and subclinical inflammation.

This Special Issue aims to bring the readers’ attention to the role of cyclitols in cardiometabolic health. We invite research papers focusing on pharmacokinetics, pharmacodynamics, metabolic function of cyclitols, in particular inositols. Additionally, we encourage the submission of reports from clinical trials evaluating the effects of cyclitols supplementation, as well as observational research associating cyclitols with different cardiometabolic outcomes. Last but not least, we also welcome deep narrative and systematic reviews summarizing current evidence on cyclitols and cardiometabolic health.

Prof. Dr. Andrzej Rynkiewicz
Dr. Michal Majewski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Cyclitols
  • Myo-inositol
  • D-chiro-inositol
  • Pinitol
  • Cardiovascular diseases Endothelial function
  • Metabolic syndrome
  • Diabetes
  • Hypertension
  • Dyslipidemia
  • Inflammation

Published Papers (1 paper)

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Research

13 pages, 1904 KiB  
Article
Beneficial In Vitro Effects of a Low Myo-Inositol Dose in the Regulation of Vascular Resistance and Protein Peroxidation under Inflammatory Conditions
by Agata Rolnik, Beata Olas, Joanna Szablińska-Piernik, Lesław Bernard Lahuta, Andrzej Rynkiewicz, Piotr Cygański, Katarzyna Socha, Leszek Gromadziński, Michael Thoene and Michał Majewski
Nutrients 2022, 14(5), 1118; https://doi.org/10.3390/nu14051118 - 7 Mar 2022
Cited by 3 | Viewed by 2493
Abstract
Oxidative stress induces functional changes in arteries. Therefore, the effect of myo-inositol, a possible anti-inflammatory/antioxidant agent was studied on human plasma and rat thoracic arteries. Aortic rings from male Wistar rats (3 months of age) were incubated with myo-inositol (1, 10 [...] Read more.
Oxidative stress induces functional changes in arteries. Therefore, the effect of myo-inositol, a possible anti-inflammatory/antioxidant agent was studied on human plasma and rat thoracic arteries. Aortic rings from male Wistar rats (3 months of age) were incubated with myo-inositol (1, 10 and 100 μM, 120 min) and analyzed using the gas chromatography (GC) method. In another experiment, aortic rings were protected first with myo-inositol (1 µM, 60 min) and then subjected to a thromboxane receptor agonist (U-46619, 0.1 nM, 60 min). Therefore, these four groups under the following conditions were studied: (i) the control in the vehicle; (ii) myo-inositol; (iii) the vehicle plus U-46619; (iv) myo-inositol plus U-46619. The hemostatic parameters of human plasma and an H2O2/Fe2+ challenge for lipid and protein peroxidation were also performed. Myo-inositol was not absorbed into the pre-incubated aortic rings as measured by the GC method (0.040 µg/mg, p ≥ 0.8688). The effect of myo-inositol was more significant in the impaired arteries due to U-46619 incubation, which resulted in an improved response to acetylcholine (% Emax: 58.47 vs. 86.69), sodium nitroprusside (logEC50: −7.478 vs. −8.076), CORM-2 (% Emax: 44.08 vs. 83.29), pinacidil (logEC50: −6.489 vs. −6.988) and noradrenaline (logEC50: −7.264 vs. −6.525). This was most likely a possible response to increased nitric oxide release (×2.6-fold, p < 0001), and decreased hydrogen peroxide production (×0.7-fold, p = 0.0012). KCl-induced membrane depolarization was not modified (p ≥ 0.4768). Both the plasma protein carbonylation (×0.7-fold, p = 0.0006), and the level of thiol groups (×3.2-fold, p = 0.0462) were also improved, which was not significant for TBARS (×0.8-fold, p = 0.0872). The hemostatic parameters were also not modified (p ≥ 0.8171). A protective effect of myo-inositol was demonstrated against prooxidant damage to human plasma and rat thoracic arteries, suggesting a strong role of this nutraceutical agent on vasculature which may be of benefit against harmful environmental effects. Full article
(This article belongs to the Special Issue Cyclitols in Cardiometabolic Syndrome)
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