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Pathogens
Special Issues
New Approaches to Combating Multidrug-Resistant Pathogens
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New Approaches to Combating Multidrug-Resistant Pathogens

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Bacterial Pathogens".

Deadline for manuscript submissions: closed (20 June 2024) | Viewed by 2090

Special Issue Editor

Prof. Dr. Yuan Liu

E-Mail Website
Guest Editor
College of Veterinary Medicine, Yangzhou University, Yangzhou, China
Interests: antimicrobial resistance; novel antibacterial strategies

Special Issue Information

Dear Colleagues,

The increasing incidence of infections caused by multidrug-resistant pathogens in the clinical setting is a global concern. More alarmingly, the scarcity of novel approved antibiotics with distinct mechanisms of action aggravates this crisis in the post-antibiotic era. There is an urgent need to develop novel antibacterial strategies, including the repurposing of existing drugs and expansion of combination therapy to deal with this problem. New approaches include, but are not limited to, the following aspects: (1) identification of novel antibacterial agents through screening from natural products, de novo synthesis, chemical modification and optimization of identified compounds; (2) discovery of novel antibiotic adjuvants from unexplored molecules or previously approved compounds to rescue the effectiveness of existing antibiotics, as well as reduce their toxicity; (3) novel alternatives to antibiotics, such as antimicrobial peptides, probiotics, antivirulence agents and phages.

For this Special Issue, we invite you to send original or review papers on aspects of novel antibacterial strategies against multidrug-resistant pathogens.

Prof. Dr. Yuan Liu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • antibacterial agents
  • antibiotic adjuvant
  • antibiotic alternatives
  • drug-resistant pathogens
  • multidrug-resistant pathogens

Published Papers (2 papers)

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Research

17 pages, 1177 KiB  
Article
Antibiotic Resistance Profile and Bio-Control of Multidrug-Resistant Escherichia coli Isolated from Raw Milk in Vietnam Using Bacteriophages
by Hoang Minh Duc, Tran Thi Khanh Hoa, Cam Thi Thu Ha, Le Van Hung, Nguyen Van Thang, Hoang Minh Son and Gary A. Flory
Pathogens 2024, 13(6), 494; https://doi.org/10.3390/pathogens13060494 - 9 Jun 2024
Viewed by 665
Abstract
E. coli is an important zoonotic pathogen capable of causing foodborne illness and bovine mastitis. Bacteriophages have been increasingly considered a promising tool to control unwanted bacteria. The aim of this study is to determine the antibiotic resistance profile of E. coli isolated [...] Read more.
E. coli is an important zoonotic pathogen capable of causing foodborne illness and bovine mastitis. Bacteriophages have been increasingly considered a promising tool to control unwanted bacteria. The aim of this study is to determine the antibiotic resistance profile of E. coli isolated from raw milk and the efficacy of phage in controlling multidrug-resistant E. coli in raw milk. Antibiotic susceptibility testing showed the highest resistance rates of E. coli isolates to co-trime (27.34%) and ampicillin (27.34%), followed by streptomycin (25.18%), tetracycline (23.02%), and the lowest resistance rates to ciprofloxacin, gentamycin, and ceftazidime, all at a rate of 2.16%. All isolates were susceptible to meropenem. Of the 139 E. coli isolates, 57 (41.01%) were resistant to at least one antibiotic, and 35 (25.18%) were classified as MDR strains. Molecular characterization indicated that 5 (3.6%) out of the 139 isolates were STEC strains carrying stx1 gene. Seven (5.04%) isolates were phenotypically identified as ESBLEC, and four isolates (2.88%) were resistant to colistin. The results of the genotypic test revealed that four out of seven ESBLEC strains carried both blaTEM and blaCTX-M-1, two harbored blaTEM, and one possessed blaCTX-M-1, while mcr-1 was detected in all four colistin-resistant E. coli isolates. In particular, one isolated E. coli strain (EM148) was determined to be a multidrug-resistant strain simultaneously carrying blaTEM, blaCTX-M-1, and mcr-1. A total of eight phages were successfully recovered from raw milk. The application of phage PEM3 significantly reduced viable counts of multidrug-resistant host EM148 in raw milk by at least 2.31 log CFU/mL at both 24 °C and 4 °C. Full article
(This article belongs to the Special Issue New Approaches to Combating Multidrug-Resistant Pathogens)
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11 pages, 571 KiB  
Communication
A Proof-of-Concept Protein Microarray-Based Approach for Serotyping of Salmonella enterica Strains
by Sascha D. Braun, Elke Müller, Katrin Frankenfeld, Dominik Gary, Stefan Monecke and Ralf Ehricht
Pathogens 2024, 13(5), 355; https://doi.org/10.3390/pathogens13050355 - 25 Apr 2024
Viewed by 957
Abstract
Salmonella enterica, a bacterium causing foodborne illnesses like salmonellosis, is prevalent in Europe and globally. It is found in food, water, and soil, leading to symptoms like diarrhea and fever. Annually, it results in about 95 million cases worldwide, with increasing antibiotic [...] Read more.
Salmonella enterica, a bacterium causing foodborne illnesses like salmonellosis, is prevalent in Europe and globally. It is found in food, water, and soil, leading to symptoms like diarrhea and fever. Annually, it results in about 95 million cases worldwide, with increasing antibiotic resistance posing a public health challenge. Therefore, it is necessary to detect and serotype Salmonella for several reasons. The identification of the serovars of Salmonella enterica isolates is crucial to detect and trace outbreaks and to implement effective control measures. Our work presents a protein-based microarray for the rapid and accurate determination of Salmonella serovars. The microarray carries a set of antibodies that can detect different Salmonella O- and H-antigens, allowing for the identification of multiple serovars, including Typhimurium and Enteritidis, in a single miniaturized assay. The system is fast, economical, accurate, and requires only small sample volumes. Also, it is not required to maintain an extensive collection of sera for the serotyping of Salmonella enterica serovars and can be easily expanded and adapted to new serovars and sera. The scientific state of the art in Salmonella serotyping involves the comparison of traditional, molecular, and in silico methods, with a focus on economy, multiplexing, accuracy, rapidity, and adaptability to new serovars and sera. The development of protein-based microarrays, such as the one presented in our work, contributes to the ongoing advancements in this field. Full article
(This article belongs to the Special Issue New Approaches to Combating Multidrug-Resistant Pathogens)
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