Ticks and Tick-Borne Pathogens at the Wildlife–Domestic Interface

A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Ticks".

Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 21071

Special Issue Editors


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Guest Editor
Institute of Parasitology, University of Veterinary Medicine Vienna, Vienna, Austria
Interests: molecular epidemiology; tick-borne diseases; emerging pathogens; wildlife; tick–host–pathogen interactions

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Guest Editor
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Avenida de las Ciencias S/N, C.P. 76230, Juriquilla, Queretaro, Mexico
Interests: control of animal ectoparasites; anti-tick vaccines; vector-borne pathogens; emerging diseases; one health
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Special Issue Information

Dear Colleagues,

Over the past few decades, the incidence, diversity, and geographic range of tick-borne diseases have increased rapidly, and this mostly coincides with the upsurge of scientific awareness and anthropogenic influence on biotic and abiotic components of natural ecosystems. Global warming, sociodemographic factors, deforestation, change of habitat, introduction/translocation of susceptible hosts, substitution of indigenous/native hosts to improve genetics, and reduction of wildlife habitats are believed to be the main underlying factors facilitating the geographic expansion of ticks and the emergence of tick-borne pathogens. Many aspects of pathogen and tick ecology depend on vertebrate hosts. Ticks are wingless arthropods, and their dispersal and distribution rely exclusively on the host movement, often culminating in the introduction of pathogens into new areas and non-resistant populations of wild animals. In this sense, wildlife seems to play a particularly important role in the eco-epidemiology of tick-borne diseases, and this is owed above all to the fact that they have a broad distribution range and thus are commonly exposed to different ticks and their associated pathogens. Moreover, they serve as a food resource and maintenance and dispersion hosts for ticks, and as potential reservoirs, they are critical for the long-term persistence of pathogens in natural and periurban settings. The rapidly growing populations and distribution ranges of some wildlife species enhance the contact rate with domestic animals, increasing the risk of infections. However, the pattern of pathogen transmission at the wildlife–domestic animal interface is still poorly understood.

This Special Issue is devoted to collecting original papers, reviews, and case reports dealing with etiology, epidemiology, pathology, diagnosis, and control of ticks, and tick-borne diseases, focusing on those shared between wild and domestic animals.

We look forward to your valuable contributions that will promote further developments in this field.

Dr. Adnan Hodžić
Prof. Dr. Consuelo Almazán
Guest Editors

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Keywords

  • Distribution
  • Domestic animals
  • Epidemiology
  • Tick-borne pathogens
  • Ticks
  • Wildlife

Published Papers (6 papers)

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Research

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16 pages, 1898 KiB  
Article
Molecular Detection of Tick-Borne Pathogens in American Bison (Bison bison) at El Uno Ecological Reserve, Janos, Chihuahua, Mexico
by Diana M. Beristain-Ruiz, Cuauhcihuatl Vital-García, Julio V. Figueroa-Millán, José J. Lira-Amaya, Javier A. Garza-Hernández, Juan R. Sánchez-Ayala, Samuel Flores-Ceballos, Carlos A. Rodríguez-Alarcón, Martha P. Olivas-Sánchez and Gabriel Pons-Monarrez
Pathogens 2021, 10(11), 1428; https://doi.org/10.3390/pathogens10111428 - 4 Nov 2021
Cited by 4 | Viewed by 2854
Abstract
American bison (Bison bison) is listed as near-threatened and in danger of extinction in Mexico. Recent studies have demonstrated the presence of several emerging pathogens at the Janos Biosphere Reserve (JBR), inhabited by one wild herd of American bison. Blood samples [...] Read more.
American bison (Bison bison) is listed as near-threatened and in danger of extinction in Mexico. Recent studies have demonstrated the presence of several emerging pathogens at the Janos Biosphere Reserve (JBR), inhabited by one wild herd of American bison. Blood samples were collected from 26 American bison in the JBR. We tested for the presence of Anaplasma marginale, Babesia bigemina, B. bovis, Borrelia burgdorferi sensu lato, and Rickettsia rickettsii DNA using nested and semi-nested PCR protocols performing duplicates in two different laboratories. Results showed three animals (11.5%) positive for B. burgdorferi s. l., three more (11.5%) for Rickettsia rickettsii, and four (19.2%) for B. bovis. Two individuals were co-infected with B. burgdorferi s. l. and B. bovis. We found no animals positive for A. marginale and B. bigemina. This is the first report in America of R. rickettsii in American bison. American bison has been described as an important reservoir for pathogens of zoonotic and veterinary importance; thus, the presence of tick-borne pathogen DNA in the JBR American bison indicates the importance of continuous wildlife health surveys. Full article
(This article belongs to the Special Issue Ticks and Tick-Borne Pathogens at the Wildlife–Domestic Interface)
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8 pages, 1175 KiB  
Article
Molecular Detection of Novel Borrelia Species, Candidatus Borrelia javanense, in Amblyomma javanense Ticks from Pangolins
by Bao-Gui Jiang, Ai-Qiong Wu, Jia-Fu Jiang, Ting-Ting Yuan, Qiang Xu, Chen-Long Lv, Jin-Jin Chen, Yi Sun, Li-Qun Fang, Xiang-Dong Ruan and Teng-Cheng Que
Pathogens 2021, 10(6), 728; https://doi.org/10.3390/pathogens10060728 - 9 Jun 2021
Cited by 8 | Viewed by 2816
Abstract
A novel Borrelia species, Candidatus Borrelia javanense, was found in ectoparasite ticks, Amblyomma javanense, from Manis javanica pangolins seized in anti-smuggling operations in southern China. Overall, 12 tick samples in 227 (overall prevalence 5.3%) were positive for Candidatus B. javanense, [...] Read more.
A novel Borrelia species, Candidatus Borrelia javanense, was found in ectoparasite ticks, Amblyomma javanense, from Manis javanica pangolins seized in anti-smuggling operations in southern China. Overall, 12 tick samples in 227 (overall prevalence 5.3%) were positive for Candidatus B. javanense, 9 (5.1%) in 176 males, and 3 (5.9%) in 51 females. The phylogenetic analysis, based on the 16S rRNA gene and the flagellin gene sequences of the Borrelia sp., exhibited strong evidence that Candidatus B. javanense did not belong to the Lyme disease Borrelia group and the relapsing fever Borrelia group but another lineage of Borrelia. The discovery of the novel Borrelia species suggests that A. javanense may be the transmit vector, and the M. javanica pangolins should be considered a possible origin reservoir in the natural circulation of these new pathogens. To our knowledge, this is the first identification of a novel Borrelia species agent in A. javanense from pangolins. Whether the novel agent is pathogenic to humans is unknown and needs further research. Full article
(This article belongs to the Special Issue Ticks and Tick-Borne Pathogens at the Wildlife–Domestic Interface)
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14 pages, 1140 KiB  
Article
Tick-Borne Pathogens in Ticks Collected from Wild Ungulates in North-Eastern Poland
by Mirosław M. Michalski, Katarzyna Kubiak, Magdalena Szczotko and Małgorzata Dmitryjuk
Pathogens 2021, 10(5), 587; https://doi.org/10.3390/pathogens10050587 - 11 May 2021
Cited by 11 | Viewed by 3099
Abstract
This study was carried out in north-eastern Poland during two hunting seasons between 2018 and 2020. Ticks (Ixodes ricinus and Dermacentor reticulatus) were removed from wild cervids and boars and examined for the presence of Borrelia spirochetes and Rickettsiales members: Rickettsia [...] Read more.
This study was carried out in north-eastern Poland during two hunting seasons between 2018 and 2020. Ticks (Ixodes ricinus and Dermacentor reticulatus) were removed from wild cervids and boars and examined for the presence of Borrelia spirochetes and Rickettsiales members: Rickettsia spp. and Anaplasma phagocytophilum. The present study contributes to the knowledge of even-toed ungulates, which are an important reservoir of the above-mentioned pathogens and a potential source of infections for humans through ticks as vectors. Almost 40% of the collected ticks (191 out of 484) were infected with the following pathogens: 3.3% with Borrelia spp., 19.2% with A. phagocytophilum and 26.9% with Rickettsia spp. Only the ticks collected from cervids carried Borrelia. Typing of the species DNA confirmed the presence of B. afzelii, B. garinii, B. lusitaniae and B. miyamotoi. An analysis of Rickettsia spp. sequences using the GenBank data revealed the presence of R. helvetica, R. raoultii and R. monacensis. Monoinfections (79.1%) dominated over co-infections (20.9%). Among co-infections, the most frequent was A. phagocytophilum/Rickettsia spp. (70%), however co-infections, including B. afzelii/A. phagocytophilum, B. afzelii/Rickettsia spp., B. miyamotoi/A. phagocytophilum and B. afzelii/B. garinii/B. lusitaniae, were also noted. Significant differences were observed in the affinity of some pathogens to their vectors. Thus, Borrelia spp. and A. phagocytophilum were more frequently detected in I. ricinus (5.3% and 23.1%) than in D. reticulatus (1.2% and 15.3%). Infection frequency with Rickettsia spp. was similar (approximately 25–29%) in both tick species. The prevalence of A. phagocytophilum and Rickettsia spp. in ticks removed from cervids was 19.8% and 27.1%, and in ticks from wild boars it was 13.3% and 24.4%, respectively. Full article
(This article belongs to the Special Issue Ticks and Tick-Borne Pathogens at the Wildlife–Domestic Interface)
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8 pages, 260 KiB  
Article
Antibodies Related to Borrelia burgdorferi sensu lato, Coxiella burnetii, and Francisella tularensis Detected in Serum and Heart Rinses of Wild Small Mammals in the Czech Republic
by Alena Žákovská, Eva Bártová, Pavlína Pittermannová and Marie Budíková
Pathogens 2021, 10(4), 419; https://doi.org/10.3390/pathogens10040419 - 1 Apr 2021
Cited by 2 | Viewed by 1778
Abstract
Wild small mammals are the most common reservoirs of pathogenic microorganisms that can cause zoonotic diseases. The aim of the study was to detect antibodies related to Borrelia burgdorferi sensu lato, Coxiella burnetii, and Francisella tularensis in wild small mammals from the Czech [...] Read more.
Wild small mammals are the most common reservoirs of pathogenic microorganisms that can cause zoonotic diseases. The aim of the study was to detect antibodies related to Borrelia burgdorferi sensu lato, Coxiella burnetii, and Francisella tularensis in wild small mammals from the Czech Republic. In total, sera or heart rinses of 211 wild small mammals (168 Apodemus flavicollis, 28 Myodes glareolus, 9 A. sylvaticus, and 6 Sorex araneus) were examined by modified enzyme-linked immunosorbent assay. Antibodies related to B.burgdorferi s.l., C. burnetii, and F. tularensis were detected in 15%, 19%, and 20% of animals, respectively. The prevalence of B. burgdorferi and F. tularensis statistically differed in localities and F. tularensis also differed in sex. Antibodies against 2–3 pathogens were found in 17% of animals with a higher prevalence in M. glareolus. This study brings new data about the prevalence of the above-mentioned pathogens. Full article
(This article belongs to the Special Issue Ticks and Tick-Borne Pathogens at the Wildlife–Domestic Interface)

Review

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15 pages, 1896 KiB  
Review
Gap Analysis of the Habitat Interface of Ticks and Wildlife in Mexico
by Carlos A. López González, Norma Hernández-Camacho, Gabriela Aguilar-Tipacamú, Salvador Zamora-Ledesma, Andrea M. Olvera-Ramírez and Robert W. Jones
Pathogens 2021, 10(12), 1541; https://doi.org/10.3390/pathogens10121541 - 25 Nov 2021
Cited by 4 | Viewed by 3504
Abstract
Mexico is a highly diverse country where ticks and tick-borne diseases (TBD) directly impact the health of humans and domestic and wild animals. Ticks of the genera Rhipicephalus spp., Amblyomma spp., and Ixodes spp. represent the most important species in terms of host [...] Read more.
Mexico is a highly diverse country where ticks and tick-borne diseases (TBD) directly impact the health of humans and domestic and wild animals. Ticks of the genera Rhipicephalus spp., Amblyomma spp., and Ixodes spp. represent the most important species in terms of host parasitism and geographical distribution in the country, although information on other genera is either limited or null. In addition, information regarding the influence of global warming on the increase in tick populations is scarce or nonexistent, despite climate conditions being the most important factors that determine tick distribution. In order to aid in the management of ticks and the risks of TBD in humans and domestic animals in Mexico, an analysis was conducted of the gaps in information on ticks with the purpose of updating the available knowledge of these ectoparasites and adapting the existing diagnostic tools for potential distribution analysis of TBD in wildlife. These tools will help to determine the epidemiological role of wildlife in the human–domestic animal interface in anthropized environments in Mexico. Full article
(This article belongs to the Special Issue Ticks and Tick-Borne Pathogens at the Wildlife–Domestic Interface)
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19 pages, 3900 KiB  
Review
Cytauxzoonosis in North America
by Mason V. Reichard, Tiana L. Sanders, Pabasara Weerarathne, James H. Meinkoth, Craig A. Miller, Ruth C. Scimeca and Consuelo Almazán
Pathogens 2021, 10(9), 1170; https://doi.org/10.3390/pathogens10091170 - 10 Sep 2021
Cited by 11 | Viewed by 5403
Abstract
Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids produced by infection of Cytauxzoon felis, an apicomplexan protozoan similar to Theileria spp. Transmitted by Amblyomma americanum, lone star tick, and Dermacentor variabilis, American dog tick, infection of C. felis [...] Read more.
Cytauxzoonosis is an emerging tick-borne disease of domestic and wild felids produced by infection of Cytauxzoon felis, an apicomplexan protozoan similar to Theileria spp. Transmitted by Amblyomma americanum, lone star tick, and Dermacentor variabilis, American dog tick, infection of C. felis in cats is severe, characterized by depression, lethargy, fever, hemolytic crisis, icterus, and possibly death. Cytauxzoonosis occurs mainly in the southern, south-central, and mid-Atlantic United States in North America, in close association with the distribution and activity of tick vectors. Infection of C. felis, although severe, is no longer considered uniformly fatal, and unless moribund, every attempt to treat cytauxzoonosis cats should be made. Herein we review cytauxzoonosis, including its etiology, affected species, its life cycle and pathogenesis, clinical signs, diagnosis, and epidemiology, emphasizing clinical pathology findings in cats infected with this important emerging tick-borne disease in North and South America. Full article
(This article belongs to the Special Issue Ticks and Tick-Borne Pathogens at the Wildlife–Domestic Interface)
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