Novel Imidazole Derivatives in Medicinal Chemistry
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 25 July 2025 | Viewed by 2499
Special Issue Editors
Interests: organic synthesis; green chemistry; heterocycles; nitro group; antimicrobial and anticancer activity; nitroimidazoles; curcuminoids; chalcones
Special Issues, Collections and Topics in MDPI journals
Interests: organic synthesis; heterocycles; nitro group; antimicrobial and antituberculosis activity; nitroimidazoles
Special Issues, Collections and Topics in MDPI journals
Interests: organic medicinal chemistry; small molecules; heterocyclic compounds; isoprenoids; drug design; synthetic processes; MAOS; drug–drug conjugates; hybrid compounds as “molecular consortia”
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Current concepts related to searching for new bioactive products, mainly including original active substances with potential application in pharmacy and medicine, are based on compounds with a previously determined structure, well-known properties and biological activity profile. Medicinal chemistry is the discipline concerned with determining the influence of chemical structure on biological activity. The practice has developed from an empirical background, involving the organic synthesis of new compounds mainly based on the modification of their structure and the identification of their biological activity. Compounds containing the imidazole moiety exhibit a wide range of biological activities. The imidazole skeleton is present in various natural compounds, such as histidine, histamine and pilocarpine alkaloids, and synthetic bioactive compounds, including cimetidine, losartan, fungicides or herbicides. These azoles show a broad spectrum of biological activities, such as anticancer, antifungal, antiviral, antibacterial, antitubercular, antiparasitic, antihistaminic, anti-inflammatory and antineuropathic.
Considering the above, we invite researchers to publish their findings on the synthesis and biological applications of imidazole derivatives, while highlighting the importance of using these molecules as a basis for developing new drugs.
This Special Issue aims to summarize the state of the art and the latest findings published in the imidazole field, as well as elucidate the future directions of these compounds in medicinal chemistry.
Dr. Dorota Olender
Dr. Justyna Żwawiak
Prof. Dr. Lucjusz Zaprutko
Guest Editors
Manuscript Submission Information
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Keywords
- imidazole
- nitroimidazole derivatives
- biological activities
- synthesis
- heterocyclic drug discovery
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