Organ Regeneration by Application of Biomaterials and Stem Cells Technology Tools
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Biopharmaceuticals".
Deadline for manuscript submissions: 12 July 2025 | Viewed by 1697
Special Issue Editor
Interests: Human induced pluripotent stem cells; disease modeling; organ regeneration; drug discovery; toxicity screening
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
There are various research areas in which stem cell technology could make substantial contributions to the development and implementation of stem cell-based models for toxicity testing. Increased use of human in vitro models of toxicity could reduce the use of animals in safety and risk assessment studies and offers the potential to dramatically enhance our understanding of the molecular basis of toxicity, leading to improved human models and assays for predicting biological responses to drugs and environmental hazards. Biomaterials are substances, applied in various fields of medicine that are used to stay in constant contact with body tissues. The most frequently practiced example is tooth filling where most people first encounter biomaterials. The other most delicate examples like cardiac repair with heart valves, and joint replacements. Various categories of biomaterials have now been successfully developed and used for more than a generation. First-generation biomaterials largely depended on being inert, or relatively inert, with minimal tissue response. Despite the wide application and its usefulness in human health, nonspecific host immune response is always a challenge to encounter which are prone to infections. Modern biomaterials science provides a large array of biomaterial designs and surface modifications that modulate the host–material interactions to prevent an aggressive foreign-body response and at the same time avoid bacterial colonization. Furthermore, the use of biological motives in the new generations of biomaterials may elicit a specific immune response. Our special issue will cover the following main aspects of the biomaterial application and characterization and proposition of new biomaterial, which could be animal and synthetic origin with less host-tissue immune responses.
- New methods and protocols to develop to characterize the animal, human and synthetic origin tissues
- Interaction of cells/stem cells and materials at the microenvironment
- Materials as model systems for stem cell growth and modulation into tissue-specific cells
- (Nano)materials and (nano)systems for therapeutic delivery
- Biomimetic materials, including biologically inspired cell-inspired synthetic tools
Dr. Saima Imran
Guest Editor
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Keywords
- stem cells
- biomaterial
- biocompatibility
- regenerative medicine
- tissue engineering
- acellular matrix
- decellularization
- disease modeling
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