New Promising Molecules for the Treatment of Retinal Neurodegenerative Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: closed (23 February 2024) | Viewed by 276
Special Issue Editors
Interests: visual science; neuroscience; neurophysiology; retina; photobiomodulation; neurodegeneration; neuroprotection
Special Issues, Collections and Topics in MDPI journals
Interests: visual science; retina; neurodegeneration
Special Issue Information
Dear Colleagues,
Retinal neurodegenerative diseases are a group of conditions characterized by the progressive degeneration of photoreceptor cells and are leading causes of irreversible vision loss worldwide. It is now well-known that after photoreceptor loss, the neural retina undergoes changes at the molecular, cellular, and synaptic levels which result in disruption and rewiring of the normal retinal circuitry, a process known as “retinal remodeling”. This has important implications for restoring vision loss in patients with retinal degeneration. The rewiring of the neural retina prevents even a restored photoreceptor’s input from being properly processed and propagated to downstream relay stations, impairing the entire visual process. While there is not currently a cure for many of these conditions, a therapeutic approach that slows down photoreceptor degeneration and redirects neural retina remodeling can avoid further vision loss and increase the chance of vision recovery when combined with therapies that correct the underlying molecular defect or use photoreceptor function surrogates, such as retinal prostheses. In recent years, various molecules, including natural products, have shown promising potential in preventing retinal degeneration. Many of these compounds have anti-inflammatory, antioxidant, and neuromodulating properties and have been able to delay the degeneration and, in some cases, improve the retinal function. This Special Issue entitled "New Promising Molecules for the Treatment of Retinal Neurodegenerative Diseases” will focus on preclinical and clinical scientific-based research showing the efficacy of novel molecules in preventing the retinal degeneration process and/or modulating the associated neural retina remodeling.
Prof. Dr. Silvia Bisti
Dr. Dario Marangoni
Dr. Massimo Contini
Guest Editors
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Keywords
- retina
- neurodegeneration
- remodeling
- molecules
- treatment
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