Discovery and Development of Novel Analgesics
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 104
Special Issue Editors
Interests: pain; neuropathy; oxidative stress; selenium; inflammation
Interests: pre-clinical models; aging; pain; oxaliplatin-induced neuropathy; pathophysiological mechanisms
Special Issue Information
Dear Colleagues,
The International Association for the Study of Pain (IASP) revised the definition of pain in 2020 to "an unpleasant sensory and emotional experience associated with, or resembling that associated with, actual or potential tissue damage". Pain affects billions of people globally and is a significant challenge to global health due to its associated disability and mortality. Chronic pain impacts autonomy, sleep, social activities, and employment, making effective pain management a major challenge in modern medicine.
The quest for novel analgesics remains a key focus in biomedical research, driven by the need to alleviate pain. Current analgesics, including non-steroidal anti-inflammatory drugs (NSAIDs), opioids, and adjuvant therapies, have limitations, such as gastrointestinal toxicity, addiction potential, and inadequate efficacy in chronic pain conditions. Therefore, there is an urgent need for novel analgesics that provide effective pain relief with fewer side effects. Technological advancements and a deeper understanding of pain biology drive the discovery and development of new analgesics, including the identification of novel molecular targets, the synthesization and screening of potential compounds, and the translation of preclinical findings into clinical practice. Innovative methodologies enhance the efficiency and precision of analgesic development. Continued collaboration and innovation are essential to meeting the clinical need for safer and more effective pain management options, ultimately improving patient outcomes and quality of life.
For this Special Issue, we invite authors to submit original and review articles on preclinical and clinical findings that enhance our understanding of novel analgesics, with the aim of compiling research from leading experts, emphasizing therapeutic agents and strategies, and identifying future directions for effective pain management innovation and therapies.
Dr. Ethel Antunes Wilhelm
Dr. Angélica Schiavom dos Reis
Guest Editors
Manuscript Submission Information
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Keywords
- analgesics
- pain management
- pain biology
- pharmacological potential
- preclinical models
- therapeutic development
- synthetic compounds
- natural compounds
- neuropathic pain
- chemotherapy-induced neuropathy
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