Natural Bioactive Compounds and Neurological Disorders: Exploiting Resources from Nature
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 46595
Special Issue Editors
Interests: drug design; neurodegenerative diseases; cancer; kinase inhibitors; natural products
Interests: drug discovery; multitarget ligands; antioxidants; neuroprotective agents; autophagy; anticancer; kinase inhibitor
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Nature has represented for millennia the main source of unique bioactive substances, significantly contributing to the treatment of a large number of diseases. Not surprisingly, pharmaceutical research has been largely inspired by nature, accomplishing big efforts to develop new pharmacological agents based or derived from natural products (NPs). Indeed, the rich polypharmacological profile of NPs offers an interesting instrument for developing innovative treatments for complex diseases, such as neurological disorders (NDs).
NDs constitute a heterogeneous group of pathologies affecting the central and the peripheral nervous systems, with a vast and complex symptomatology. Given their estimated incidence of more than 1 billion people worldwide and no efficacious pharmacological therapy available, there is a high request of new pharmaceutical options able to counteract their insurgence and progression. To help reaching this goal, this Special Issue aims at collecting relevant studies focusing on: (i) identification, design, and synthesis of NP-inspired derivatives, able to target specific NDs mechanisms, (ii) PK/PD profiling of NPs, and (iii) drug delivery system application to improve NPs’ biopharmaceutical properties.
The journal Pharmaceuticals invites experts in the field to contribute to this Special Issue with both reviews and original research articles focusing on exploiting natural products to develop innovative pharmaceutical tools for neurological disorders.
Dr. Simona Sestito
Prof. Dr. Simona Rapposelli
Dr. Massimiliano Runfola
Guest Editors
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Keywords
- neurological disorders
- neuroprotective agents
- neuronal injury
- phytochemical screening
- natural products
- phenotypic drug discovery
- mechanism of action
- nanoparticles
- drug delivery
- natural bioactive products
- autophagic promoters
- ADMET optimization
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