New Approaches for the Prevention and Alleviation of Metabolic Syndrome 2024

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 695

Special Issue Editor


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Guest Editor
Department of Food and Nutrition, Sookmyung Women’s University, Cheongpa-ro 47-gil 100, Yongsan-gu, Seoul 140-472, Republic of Korea
Interests: lipid metabolism; metabolic disorder of post-menopausal women; free radical research; diabetes; obesity
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Special Issue Information

Dear Colleagues,

Metabolic syndrome is defined as a cluster of conditions characterized by impaired glucose metabolism, hypertension, central obesity, low LDL-C, and high triglyceride levels. It also promotes glucose intolerance and chronic systemic inflammatory conditions characterized by immune cell infiltration, and this immune system activation increases the risk of serious disease following viral infection. In addition, studies have been reported regarding an increase in diseases associated with various metabolic disorders, such as nonalcoholic fatty liver, psoriasis, and IBD. Metabolic disease tends to progress quietly and gradually, rather than with acute symptoms. Due to the recent COVID-19 pandemic, increased processed food and salt intake, surplus energy accumulation, sedentary lifestyle, and reduced physical activity are thought to be risk factors for an increase in metabolic disease. Therefore, the discovery of drugs related to metabolic diseases and metabolic disorders has an important meaning in this difficult period. I hope that this Special Issue will provide an opportunity to help all patients and further the development of the scientific community. In order to achieve this, the cooperation of all our valuable colleagues, including yourself, is essential.

We are pleased to welcome papers reviewing the most recent research on this topic in the present thematic issue.

We look forward to your contribution.

Dr. Seong-Hee Maria Ko
Guest Editor

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Keywords

  • metabolic disorder
  • IBD
  • diabetes
  • hypertension
  • obesity

Published Papers (1 paper)

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Research

19 pages, 44609 KiB  
Article
Effect of GLP-1 Receptor Agonist on Ischemia Reperfusion Injury in Rats with Metabolic Syndrome
by Marko Ravic, Ivan Srejovic, Jovana Novakovic, Marijana Andjic, Jasmina Sretenovic, Maja Muric, Marina Nikolic, Sergey Bolevich, Kirill Alekseevich Kasabov, Vladimir Petrovich Fisenko, Aleksandra Stojanovic and Vladimir Jakovljevic
Pharmaceuticals 2024, 17(4), 525; https://doi.org/10.3390/ph17040525 - 19 Apr 2024
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Abstract
Metabolic syndrome (MetS) represents an important factor that increases the risk of myocardial infarction, and more severe complications. Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs) exhibit cardioprotective potential, but their efficacy in MetS-related myocardial dysfunction has not been fully explored. Therefore, we aimed to [...] Read more.
Metabolic syndrome (MetS) represents an important factor that increases the risk of myocardial infarction, and more severe complications. Glucagon Like Peptide-1 Receptor Agonists (GLP-1RAs) exhibit cardioprotective potential, but their efficacy in MetS-related myocardial dysfunction has not been fully explored. Therefore, we aimed to assess the effects of exenatide and dulaglutide on heart function and redox balance in MetS-induced rats. Twenty-four Wistar albino rats with induced MetS were divided into three groups: MetS, exenatide-treated (5 µg/kg), dulaglutide-treated (0.6 mg/kg). After 6 weeks of treatment, in vivo heart function was assessed via echocardiography, while ex vivo function was evaluated using a Langendorff apparatus to simulate ischemia-reperfusion injury. Heart tissue samples were analyzed histologically, and oxidative stress biomarkers were measured spectrophotometrically from the coronary venous effluent. Both exenatide and dulaglutide significantly improved the ejection fraction by 3% and 7%, respectively, compared to the MetS group. Histological analyses corroborated these findings, revealing a reduction in the cross-sectional area of cardiomyocytes by 11% in the exenatide and 18% in the dulaglutide group, indicating reduced myocardial damage in GLP-1RA-treated rats. Our findings suggest strong cardioprotective potential of GLP-1RAs in MetS, with dulaglutide showing a slight advantage. Thus, both exenatide and dulaglutide are potentially promising targets for cardioprotection and reducing mortality in MetS patients. Full article
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