Innovative Concepts for Pharmacological Treatment of Cardiac Arrhythmias

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: closed (29 October 2021)

Special Issue Editors


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Guest Editor
Department of Cardiology II (Electrophysiology), University Hospital Münster, Münster, Germany
Interests: cardiac electrophysiology; experimental models on cardiac arrhythmias; catheter ablation; implantable devices

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Co-Guest Editor
Department of Cardiology II - Electrophysiology, University Hospital Münster, Münster, Germany
Interests: arrhythmia; sudden death; translational research; long QT syndrome

Special Issue Information

Dear Colleagues,

I would like to inform you that the Pharmaceuticals Special Issue “Innovative Concepts for Pharmacological Treatment of Cardiac Arrhythmia” is now accepting manuscripts for publication. Pharmacological treatment of cardiac arrhythmias still represents a challenge, as the number of available antiarrhythmic agents is limited to a few compounds. In particular, in the presence of chronic heart failure, antiarrhythmic drug therapy is mainly limited to amiodarone. Therefore, development of new compounds as well as identification of antiarrhythmic properties of non-cardiovascular drugs is an important topic for future development of cardiovascular therapies. Contributions to this issue include submission of original articles, review, short communications, and editorials.

Prof. Dr. Gerrit Frommeyer
Dr. Christian Ellermann
Guest Editors

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Keywords

  • antiarrhythmic drugs
  • ventricular arrhythmias
  • atrial fibrillation
  • sudden cardiac death

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Published Papers (1 paper)

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Research

9 pages, 1332 KiB  
Article
Antiarrhythmic Effect of Ranolazine in Combination with Selective NCX-Inhibition in an Experimental Model of Atrial Fibrillation
by Julian Wolfes, Christian Ellermann, Niklas Broer, Benjamin Rath, Kevin Willy, Patrick Robert Leitz, Philipp Sebastian Lange, Lars Eckardt and Gerrit Frommeyer
Pharmaceuticals 2020, 13(10), 321; https://doi.org/10.3390/ph13100321 - 20 Oct 2020
Cited by 5 | Viewed by 2599
Abstract
The aim of this study was to investigate the effects of a combination of ranolazine with different selective inhibitors of the Na+/Ca2+-exchanger (NCX) in an established experimental model of atrial fibrillation (AF). Eighteen hearts of New Zealand white rabbits [...] Read more.
The aim of this study was to investigate the effects of a combination of ranolazine with different selective inhibitors of the Na+/Ca2+-exchanger (NCX) in an established experimental model of atrial fibrillation (AF). Eighteen hearts of New Zealand white rabbits were retrogradely perfused. Atrial catheters were used to record monophasic action potentials (aPRR). Hearts were paced at three different cycle lengths. Thereby, atrial action potential durations (aAPD90), atrial effective refractory periods (aERP) and atrial post-repolarization refractoriness were obtained. Isoproterenol and acetylcholine were employed to increase the occurrence of AF. Thereafter, the hearts were assigned to two groups (n = 9 each group) and additionally perfused with a combination of 10 µM ranolazine and 1 µM of the selective NCX-inhibitor ORM-10103 (group A: Rano-ORM) or 10 µM ranolazine and 1 µM of another NCX-inhibitor, SEA0400 (group B: Rano-SEA). The infusion of Iso/ACh led to a shortening of aAPD90, aERP, aPRR and the occurrence of AF episodes was significantly increased. Additional perfusion with ranolazine and ORM-10103 (group A) significantly prolonged the refractory periods and aPRR and AF episodes were effectively reduced. In group B, Rano-SEA led to a slight decrease in aAPD90 while aERP and aPRR were prolonged. The occurrence of AF episodes was consecutively reduced. To our knowledge, this is the first study investigating the effect of ranolazine combined with different selective NCX-inhibitors in an isolated whole-heart model of AF. Both combinations prolonged aERP and aPRR and thereby suppressed the induction of AF. Full article
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