Biological and Pharmacological Research on Indole-3-Carbinol (I3C) and Its Derivatives
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 15 January 2025 | Viewed by 31
Special Issue Editor
Interests: genetics; natural compounds; antiviral activity
Special Issue Information
Dear Colleagues,
Indole-3-carbinol (I3C) is a natural compound found in vegetables from the Brassicaceae family. It has been extensively studied for its biological and pharmacological properties, including it ability to suppress cell cycle progression, block cancer cell migration, promote apoptosis, and inhibit tumor growth and Sars-CoV-2 viral egression. In addition, it has demonstrated cardioprotective, antioxidant, anti-inflammatory, antiangiogenetic, and antimicrobial properties. Although it interacts with different pathways, it has been proposed that I3C and its synthetic derivatives may influence human cells by directly inhibiting them with specific enzymatic target proteins. Since I3C affects various cellular mechanisms, it is not surprising to researchers proposing its use for treating or preventing different cancer types and other diseases. On the other hand, I3C is a metabolically unstable compound and decomposes under gastric pH conditions when it is orally administered. Therefore, one of the main focuses for researchers is to make changes to I3C’s chemical structure characteristics to improve its stability. Different design strategies were applied to enhance the possibility of performing lead optimization and obtaining derivatives with a better pharmacodynamic and pharmacokinetic profile than I3C.This Special Issue aims to invite both reviews and original articles that shed light on the biosynthetic processes and synthetic procedures for obtaining I3C and its main derivatives. This Special Issue’s objective is also to explore the characteristics, mechanism of action, and therapeutic potential of I3C and/or its derivatives both in health and in preventing and treating various diseases.
Dr. Federica Centofanti
Guest Editor
Manuscript Submission Information
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Keywords
- indole-3-carbinol
- natural and synthetic derivatives of I3C
- synthetic procedures
- biosynthetic processes
- in vitro, in vivo and clinical studies
- mechanism of action
- biological properties
- pharmacological properties
- potential therapeutic applications in health and disease
