Adenosine Receptors as Attractive Targets in Human Diseases
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 30156
Special Issue Editors
Interests: medicinal chemistry; rational drug design; heterocyclic compounds; structure–activity relationships; adenosine receptor ligands; carbonic anhydrase inhibitors; protein kinase CK1 and CK2 inhibitors; ecto-5'-nucleotidase (CD73) inhibitors
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; rational drug design; heterocyclic compounds; structure–activity relationships; adenosine receptor ligands; carbonic anhydrase inhibitors; protein kinase CK1 and CK2 inhibitors; ecto-5'-nucleotidase (CD73) inhibitors
Special Issues, Collections and Topics in MDPI journals
Interests: medicinal chemistry; rational drug design; heterocyclic compounds; structure–activity relationships; adenosine receptor ligands; carbonic anhydrase inhibitors; protein kinase CK1 and CK2 inhibitors; ecto-5'-nucleotidase (CD73) inhibitors
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Adenosine is a ubiquitous neuromodulator, both in the central and peripheral nervous systems, and is also present in almost all organs and tissues. It activates G-protein coupled receptors, classified as A1, A2A, A2B and A3 adenosine receptor (AR) subtypes, which have different tissue/organ distribution and effector couplings. Thus, adenosine modulates a wide variety of physiological processes, such as neuronal and cardiovascular activities, immune system functions and cellular metabolism, and it is also implicated in different pathological conditions. Although AR roles are still far from being completely understood, targeting ARs has been proven to be a valid mean for therapeutic and diagnostic intervention in several diseases, thus prompting scientists to search for new molecules able to modulate, directly or indirectly, AR functions. This Special Issue is aimed at providing the reader with recent advances in the field of ARs as target in human diseases.
Authors are invited to submit original articles dealing with their research in this area of investigation. The proposed topics include, but are not limited to, new AR ligands, AR allosteric modulators or enzyme modulators, designed as chemical probe for the study of adenosine pharmacological role and to highlight the AR-mediated therapeutic effects. Review articles summarizing the current knowledge on adenosine receptors and their ligands will be also of interest.
Prof. Vittoria Colotta
Prof. Daniela Catarzi
Dr. Flavia Varano
Guest Editors
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Keywords
- G protein-coupled receptors
- adenosine receptors
- adenosine receptor ligands
- allosteric modulators
- rational design
- multitarget-directed drugs
- computational studies
- molecular docking
- therapeutics
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