Fungal-Derived Natural Product: Synthesis, Function, and Applications
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Natural Products".
Deadline for manuscript submissions: closed (29 March 2023) | Viewed by 4313
Special Issue Editor
Interests: my research focuses on the underlying infectious mechanisms of vector-borne diseases such as malaria, dengue and Zika in insects by discovering targets against these diseases; by screening our recently established Global Library of Fungal Extracts (GFEL); my goal is to find new compounds that block transmission of these diseases
Special Issue Information
Dear Colleagues,
Natural products from fungi play unique, critical, and irreplaceable roles in human health. However, the frequency of FDA approvals of new drugs derived from natural products has been declining since the 1990s, and industry has shifted its focus to synthetic chemicals for drug discovery. Some researchers from the pharmaceutical industry have questioned the potential for drug discovery from natural products. After human beings entered the 21st century, the rapid development of molecular biology, genomic mining, and microbial culturing advances have pushed natural products into a new era. In addition, high-throughput sequencing technologies not only speed up sequencing, but also reduce costs, enabling the sequencing of large numbers of fungal genomes. Currently, based on bioinformatics analysis, it is known that most of the biosynthetic gene clusters of natural products are not expressed in experimental conditions, and many genes are involved in the regulation of the synthesis process. Genome mining through machine learning to study fungal omics data has shown great promise for unraveling synthetic pathways and regulatory mechanisms, which will lead to the discovery of many new compounds and open new opportunities for the discovery of natural fungal drug products.
Dr. Guodong Niu
Guest Editor
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Keywords
- fungi
- natural product
- secondary metabolite
- function
- regulation
- biosynthesis
- genome mining
- gene cluster
- drug discovery
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