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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue polices and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Transient Receptor Potential (TRP) Channels as Novel Therapeutic Targets

edited by

Dana Cucu

submission deadline 20 Oct 2024 | 12 articles | Viewed by 17325 | Submission Open

Keywords: TRP channels; signalling pathways; tumoral process; pain; migration; apoptosis; inflammation; oxidative stress

(This special issue belongs to the Section Pharmacology)

Adjuvant Therapies for Cancer Treatment

edited by

Fuyi Wang

and

Andréia Machado Leopoldino

submission deadline 20 Oct 2024 | 9 articles | Viewed by 15063 | Submission Open

Keywords: drug repurposing; combined therapies; new compounds; drug resistance; chemosensitization; antitumoral strategies

(This special issue belongs to the Section Pharmacology)

Therapeutic Potential of Cannabinoid Receptors Type 1 and 2—Novel Insights for Enhancing the Chance of Clinical Success

edited by

Uwe M. Grether

submission deadline 20 Oct 2024 | 7 articles | Viewed by 13800 | Submission Open

Keywords: endocannabinoid system (ECS); cannabinoid receptor type 1 (CB1R); cannabinoid receptor type 2 (CB2R); cannabinoids; ligand

(This special issue belongs to the Section Pharmacology)

20th Anniversary of Pharmaceuticals–Drug Design and Pharmacological Advances in Neurodegenerative Disease

edited by

Elena Cichero

and

Michele Tonelli

submission deadline 20 Oct 2024 | 7 articles | Viewed by 10909 | Submission Open

Keywords: neurodegeneration; neuroprotective agents; chemical synthesis; drug design; GPCR; enzyme; screening

(This special issue belongs to the Section Medicinal Chemistry)

Novel Therapies for the Treatment of Metastatic Prostate Cancer

edited by Melissa LaBonte Wilson

submission deadline 20 Oct 2024 | 2 articles | Viewed by 9943 | Submission Open

Keywords: prostate cancer; mCSPC; mCRPC; drug resistance; androgen receptor-signaling inhibitors; bipolar androgen therapy; EZH2 inhibition; autophagy inhibition; prostate-specific membrane antigen-targeted therapy; immunotherapy; DNA repair inhibition; PI3K/AKT/mTOR inhibition; metastasis- and prostate-directed radiotherapy; inflammation; tumor microenvironment

(This special issue belongs to the Section Medicinal Chemistry)

Alzheimer’s Disease: Small-Molecule Modulators of Novel Therapeutic Pathways

edited by

Sachin P. Patil

submission deadline 20 Oct 2024 | 3 articles | Viewed by 5396 | Submission Open

Keywords: Alzheimer’ s disease; dementia; neurodegeneration; small molecules; disease mechanisms; drug discovery and design

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy of Neurodegeneration Disorders

edited by

Magdalena Kondeva-Burdina

and Maya Georgieva

submission deadline 20 Oct 2024 | 2 articles | Viewed by 3293 | Submission Open

Keywords: neurodegeneration; inflammation; oxidative stress; neuroprotection; new biologically active molecules; heterocycles; synthesis; in silico drug design; pyrrole; MW-assisted synthesis; pharmaceutical chemistry

(This special issue belongs to the Section Pharmacology)

Novel Therapeutic Approaches for Cystic Fibrosis

edited by

Giorgio Cozza

Andrea Venerando

and

Ilaria Artusi

submission deadline 20 Oct 2024 | 2 articles | Viewed by 2505 | Submission Open

Keywords: cystic fibrosis; CFTR mutations; pathophysiology; inflammation; infection; high-throughput screening; drug development; therapies; treatments; clinical trials

(This special issue belongs to the Section Pharmacology)

The 20th Anniversary of Pharmaceuticals—Ethnopharmacology in Latin America

edited by

Angel Josabad Alonso-Castro

submission deadline 20 Oct 2024 | 1 articles | Viewed by 2111 | Submission Open

Keywords: Latin America; preclinical; clinical; ethnobotany; pharmacology; chemical standardization; herbal products

(This special issue belongs to the Section Natural Products)

Pharmacotherapy for Neuropathic Pain

edited by Vittoria Borgonetti and

Nicoletta Galeotti

submission deadline 20 Oct 2024 | 1 articles | Viewed by 1337 | Submission Open

Keywords: neuropathic pain; neuroinflammation; pharmacology; microglia; astrocytes; allodynia; hyperalgesia; personalized therapy; chronic pain; sex differences

(This special issue belongs to the Section Pharmacology)

Phage Discovery and Phage Therapy

edited by Sha Liu and Nan Hao

submission deadline 20 Oct 2024 | Viewed by 746 | Submission Open

Keywords: phage discovery; phage biology; phage engineering; phage lysins; phage therapy

(This special issue belongs to the Section Biopharmaceuticals)

New Insights into Therapy for Alzheimer’s and Other Neurodegenerative Diseases

edited by Robert Joseph Shmookler Reis, Meenakshisundaram Balasubramaniam and

Srinivas Ayyadevara

submission deadline 22 Oct 2024 | 9 articles | Viewed by 20353 | Submission Open

Keywords: Alzheimer’ s disease; Parkinson’ s disease; Huntington’ s disease; amyotrophic lateral sclerosis; neurodegeneration; inflammation; anti-inflammatory drugs; post-translational modifications; protein misfolding; protein aggregation

(This special issue belongs to the Section Pharmacology)

Current Therapies for Endometriosis, Adenomyosis and Endometrial Cancer

edited by Ambrogio Pietro Londero,

Anjeza Xholli

and

Angelo Cagnacci

submission deadline 22 Oct 2024 | 5 articles | Viewed by 15292 | Submission Open

Keywords: endometriosis; adenomyosis; endometrial cancer; hormonal therapy; non-hormonal therapy; pain management; fertility preservation; complementary/alternative medicine; radiation therapy; chemotherapy; immunotherapy

(This special issue belongs to the Section Pharmacology)

Data-Driven Biomarker and Drug Discovery for Complex Disease

edited by

Yin Huang

, Tao Ban and

Huimin Guo

submission deadline 22 Oct 2024 | 3 articles | Viewed by 2812 | Submission Open

Keywords: cardiovascular disease; diabetes; neurodegenerative diseases; genomics; proteomics; metabolomics; systems biology; data mining; biomarker; drug discovery

(This special issue belongs to the Section Pharmacology)

Use of Anesthetic Agents: Management and New Strategy

edited by

José Luis Guerrero-Orriach

and María Dolores Carmona Luque

submission deadline 22 Oct 2024 | 1 articles | Viewed by 2028 | Submission Open

Keywords: anesthetic agents; anesthetic drugs; anesthetic; general anesthetic agents; therapeutic tools

(This special issue belongs to the Section Pharmacology)

Telomere Length and Cardiovascular Disease: A Precursor Marker and Therapeutic Target

edited by

Marios Sagris

and

Dimitris Tousoulis

submission deadline 22 Oct 2024 | Viewed by 289 | Submission Open

Keywords: telomere length; DNA; chromosomes; cardiovascular disease; atherosclerosis; coronary artery disease; valvular disease; heart failure; arrhythmias; peripheral artery disease

(This special issue belongs to the Section Biopharmaceuticals)

Pharmacogenomics for Precision Medicine

edited by

Vacis Tatarūnas

submission deadline 23 Oct 2024 | 3 articles | Viewed by 2049 | Submission Open

Keywords: pharmacogenomics in precise therapy; tailored medicine; pharmacoeconomics; personalized medicine; education in pharmacogenomics and precise medicine; future directions in pharmacogenomics; pharmacogenomics and phenotype; genotype; epigenetic variation; and gene expression axis in pharmacogenomics

(This special issue belongs to the Section Pharmacology)

Peptide Biomaterials for Pharmaceutical Applications

edited by

Miguel Mendez-Rojas

, Sergio Alberto Bernal Chavez and

Sergio Alcalá Alcalá

submission deadline 24 Oct 2024 | Viewed by 566 | Submission Open

Keywords: peptides; pharmaceutical applications; nanomedicine; peptide materials; peptide conjugates; drug delivery systems; nanocarriers; biologics

(This special issue belongs to the Section Pharmaceutical Technology)

Enzyme Inhibitors: Potential Therapeutic Approaches

edited by

Phaedra Eleftheriou

submission deadline 25 Oct 2024 | 10 articles | Viewed by 21843 | Submission Open

Keywords: enzyme inhibitors; drug targets; therapeutic approaches

(This special issue belongs to the Section Medicinal Chemistry)

Plant-Derived Natural Compounds as Bioactive Molecules with Beneficial Effects on Human Health

edited by

Diego Morales

submission deadline 25 Oct 2024 | 6 articles | Viewed by 10659 | Submission Open

Keywords: plant bioactives; bioactive compounds; gut microbiome; immune-modulatory; antioxidant; hypocholesterolemic; antihypertensive; clinical trials

(This special issue belongs to the Section Natural Products)

Drug Safety and Relevant Issues in the Real-World 2024

edited by

Maria Antonietta Barbieri

Natasha Irrera

and

Irma Convertino

submission deadline 25 Oct 2024 | 6 articles | Viewed by 10052 | Submission Open

Keywords: drug safety; real-world data; prescriptive appropriateness; effectiveness; pharmacovigilance; pharmacoepidemiology; patients’ clinical outcomes; adverse drug reactions

Biodegradable Polymeric Nanosystems for Drug Delivery

edited by

Ewa Olȩdzka

and

Urszula Piotrowska

submission deadline 25 Oct 2024 | 5 articles | Viewed by 7587 | Submission Open

(This special issue belongs to the Section Pharmaceutical Technology)

Therapeutic Agents for the Treatment of Tumors in the CNS

edited by

Gautham Gampa

Sani H. Kizilbash

and

Shannon P. Fortin Ensign

submission deadline 25 Oct 2024 | 4 articles | Viewed by 7380 | Submission Open

Keywords: primary brain tumors; glioblastoma; brain metastases (BMs); neuro-oncology; blood– brain barrier (BBB); drug delivery; preclinical PK/PD; molecularly targeted agents; immunotherapy; new modalities

Pyrazole and Thiazole Derivatives in Medicinal Chemistry

edited by

Dimitris Matiadis

Antonella Messore

and

Nicolas Primas

submission deadline 25 Oct 2024 | 5 articles | Viewed by 6976 | Submission Open

(This special issue belongs to the Section Medicinal Chemistry)

Selected Papers from the 9th International Electronic Conference on Medicinal Chemistry (ECMC2023)

edited by

Alfredo Berzal-Herranz

and

Maria Emília De Sousa

submission deadline 25 Oct 2024 | 4 articles | Viewed by 3749 | Submission Open

Keywords: small molecules as drug candidates; biomolecules; natural products; phages; and cells as therapeutic tools; biological targets and biomarkers; radiopharmaceutical sciences; radiochemistry; (hybrid) imaging; and nuclear medicine; pharmacokinetics and pharmacodynamics; pharmaceutical preparations and drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Exploring Natural Products as Modulators of Oxidative Stress in Health and Disease

edited by

Antonella Di Sotto

and

Silvia Di Giacomo

submission deadline 25 Oct 2024 | 3 articles | Viewed by 2782 | Submission Open

Keywords: plant-based herbal extracts; waste; natural substances; medicinal plants; food supplements; liver; cancer; noncommunicable diseases; chemoprevention; molecular mechanisms; adverse reactions; safety

(This special issue belongs to the Section Pharmacology)

Emerging Freeze Drying and Spray Drying Techniques

edited by

Lauryna Pudžiuvelytė

and

Jurga Bernatoniene

submission deadline 25 Oct 2024 | 1 articles | Viewed by 2239 | Submission Open

Keywords: freeze drying; spray drying; microencapsulation; emulsions; herbal extracts; essential oil; natural ingredients; active ingredients; wall materials; polysaccharides; powders; physicochemical characteristics; microparticles; encapsulation efficiency; biological activity; pharmaceutical forms (tablets; capsules; solutions; gels; etc.); study of stability; study of release in vitro; active compound(s) and wall material interaction; morphology of microparticles

(This special issue belongs to the Section Pharmaceutical Technology)

Organochalcogen Molecules and Materials in Medicinal Chemistry

edited by

Agata Pacuła-Miszewska

and

Jacek Ścianowski

submission deadline 25 Oct 2024 | 2 articles | Viewed by 2042 | Submission Open

Keywords: organochalcogen compounds; organochalcogen materials; modern synthetic protocols; biological activity

(This special issue belongs to the Section Medicinal Chemistry)

Antimicrobial Peptides: Design, Synthesis and Pharmaceutical Applications

edited by

Je-Wen Liou

submission deadline 25 Oct 2024 | 1 articles | Viewed by 1307 | Submission Open

Keywords: natural antimicrobial peptides; antimicrobial peptide design and modifications; antimicrobial peptide structures; antimicrobial peptide stability; mechanism/mode of action of antimicrobial peptides; antimicrobial peptide applications; modulation of infection-related immune and inflammation by peptides; extended applications of antimicrobial peptides for treatments of cancers and other diseases; clinical trials of pharmaceutical peptides

(This special issue belongs to the Section Biopharmaceuticals)

New Targets and Experimental Therapeutic Approaches for Cancers

edited by

Saurabh Agarwal

and Rohit K. Srivastava

submission deadline 25 Oct 2024 | 1 articles | Viewed by 948 | Submission Open

Keywords: cancer; pharmaceutical therapy; therapeutic targets; drug delivery; immunotherapy; precision medicine; emerging pharmaceutical technologies; combination therapy

(This special issue belongs to the Section Pharmacology)

Lithium in Psychiatric Therapy: Celebrating 75th Anniversary

edited by

Janusz K. Rybakowski

and Ewa Ferensztajn-Rochowiak

submission deadline 25 Oct 2024 | 1 articles | Viewed by 776 | Submission Open

Keywords: lithium; bipolar disorder; mania; depression; the prevention of recurrences; suicide; dementia; immunomodulation; genetics; kidney function

(This special issue belongs to the Section Pharmacology)

From Bench to Bedside: Expanding the Scope of Thioredoxin Reductase Inhibitors as Promising Therapeutics for Tumors, Inflammatory Disorders, and Infectious Diseases

edited by

Jianqiang Xu

and

Jun Lu

submission deadline 25 Oct 2024 | Viewed by 340 | Submission Open

Keywords: thioredoxin reductase; thioredoxin; pharmaceutical effect; small molecule inhibitors; natural herb extracts; antioxidants; trace elements; drug screening/validation; inhibitory effect; mechanism; redox regulation; oxidative stress; tumor cell death; inflammation; infection

(This special issue belongs to the Section Pharmacology)

The 20th Anniversary of Pharmaceuticals—Photonics in Drug Delivery

edited by

Iván Bravo Pérez

and

Carlos Alonso-Moreno

submission deadline 25 Oct 2024 | Viewed by 336 | Submission Open

Keywords: photo-biosensors; photodynamic therapy; nanotheragnostic; photosensitive biomarkers; photonic spectroscopy

(This special issue belongs to the Section Pharmaceutical Technology)

Recent Advances in Stomach and Intestinal Drug Delivery Systems

edited by

Agustin Rascon-Chu

submission deadline 25 Oct 2024 | Viewed by 246 | Submission Open

Keywords: stomach delivery; intestinal delivery; meso– nanostructured carriers; micro– nanoparticles/capsules; permeability enhancement; stability; absorption enhancement; gut delivery

(This special issue belongs to the Section Pharmaceutical Technology)

P2X Receptors and Their Pharmacology

edited by

Robson Xavier Faria

submission deadline 25 Oct 2024 | Viewed by 232 | Submission Open

Keywords: compounds; substances; synthetic; natural product; inhibitor; purinergic receptor; ATP; antagonista

(This special issue belongs to the Section Pharmacology)

Novel Antimicrobials and the Antimicrobial Activity: New Advances

edited by

Davide Carcione

Luigi Principe

and

Cattaneo Dario

submission deadline 25 Oct 2024 | Viewed by 229 | Submission Open

Keywords: multi-drug resistance; infection; mechanism of action; resistance mechanisms; therapeutic medicine; diagnostic tools; antimicrobial stewardship; pharmacokinetics/pharmacodynamics

(This special issue belongs to the Section Pharmacology)

Antimycobacterial Agents: New Advances in Combating Drug-Resistant Tuberculosis

edited by Junhao Zhu

submission deadline 25 Oct 2024 | Viewed by 164 | Submission Open

Keywords: antimycobacterial agents; mycobacterium tuberculosis; drug-resistant; tuberculosis; antimicrobial

(This special issue belongs to the Section Pharmacology)

Common Medications Used in Anesthesia

edited by Michał Jan Stasiowski

submission deadline 25 Oct 2024 | Viewed by 129 | Submission Open

Keywords: anesthesia; medications; pharmacology; perioperative care; drug interactions; patient safety; clinical practice; anesthesia management; drug development; patient outcomes

(This special issue belongs to the Section Medicinal Chemistry)

Nanomaterial Complexes Used in Cancer Therapies: Opportunities and Challenges

edited by

Ruizhuo Ouyang

submission deadline 25 Oct 2024 | Viewed by 128 | Submission Open

Keywords: smart nanomaterials; stimuli-responsive methods; multimodal imaging; drug delivery; cancer diagnosis and therapy; quantum dots; metallic nanoparticles; liposomes; dendrimers; micelles; polymeric nanoparticles

(This special issue belongs to the Section Pharmaceutical Technology)

Natural Products in Diabetes Mellitus: 2nd Edition

edited by

Ana Angelica Feregrino-Perez

submission deadline 28 Oct 2024 | 2 articles | Viewed by 3175 | Submission Open

Keywords: natural products; hypoglycemia; phenolic compounds; diabetes mellitus; therapeutic; ROS

(This special issue belongs to the Section Natural Products)

Drug-Induced and Herbal Hepatotoxicity and Methods of Its Prevention

edited by

Anna Merwid-Ląd

and

Malgorzata Trocha

submission deadline 29 Oct 2024 | 7 articles | Viewed by 23796 | Submission Open

Keywords: drug-induced hepatotoxicity; herbal hepatotoxicity; acute and chronic liver damage; pathomechanisms of liver injury; oxidative stress; inflammation; apoptosis and necrosis; fibrosis

(This special issue belongs to the Section Pharmacology)

Design, Synthesis and Development of Novel Antiviral Agents

edited by

Antonio Lupia

submission deadline 30 Oct 2024 | 1 articles | Viewed by 1940 | Submission Open

Keywords: viruses; emerging viral diseases; infectious diseases; antiviral agents; small molecules; structure− activity relationship (SAR) studies; drug design (DD) and synthesis; computer-aided drug discovery (CADD); medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacotherapy for Alzheimer’s Disease

edited by

Gabriela Dumitrița Stanciu

submission deadline 30 Oct 2024 | 1 articles | Viewed by 1760 | Submission Open

Keywords: Alzheimer’ s disease; pharmacotherapy; therapeutic editing tools; repurposing existing therapeutics; multi-target-directed ligands; preclinical studies; neurodegeneration; drug development; neuroprotection; cannabinoid-based pharmaceuticals; single-molecule drugs or whole-plant extracts of Cannabis sativa L.

(This special issue belongs to the Section Pharmacology)

The 20th Anniversary of Pharmaceuticals — Multi-Targeted Natural Products as Therapeutics

edited by

Elena Y. Enioutina

Kathleen M. Job

and

Catherine Sherwin

submission deadline 31 Oct 2024 | 19 articles | Viewed by 45030 | Submission Open

Keywords: natural products; medicinal herbs; marine products; animal products; bioactive compounds; multifactorial diseases; multi-targeting phytochemicals

(This special issue belongs to the Section Natural Products)

Recent Advances and Future Approaches in Preventive and Therapeutic Effects of Vanadium Complexes

edited by

Monika Papież

and

Wirginia Krzyściak

submission deadline 31 Oct 2024 | 5 articles | Viewed by 8426 | Submission Open

Keywords: vanadium compounds; antidiabetic; insulinomimetic; antiobesity; anticancer; antimicrobial; cardioprotective; neuroprotective

(This special issue belongs to the Section Medicinal Chemistry)

Current Advances, Applications and Future Development of Transition Metal Complexes

edited by

Domenico Iacopetta

submission deadline 31 Oct 2024 | 2 articles | Viewed by 4620 | Submission Open

Keywords: transition metal complexes; synthesis; catalysis; ligands; biological activity; applications; enzyme inhibition

(This special issue belongs to the Section Medicinal Chemistry)

New and Emerging Treatment Strategies for Gastrointestinal Diseases

edited by

Daniele Maria-Ferreira

submission deadline 31 Oct 2024 | 1 articles | Viewed by 1138 | Submission Open

Keywords: gastrointestinal diseases; gastrointestinal homeostasis; gastrointestinal injuries; gastrointestinal disturbances; dysbiosis; bile acid; inflammatory bowel diseases; diarrhea

(This special issue belongs to the Section Pharmacology)

Drug Delivery across the Blood–Brain Barrier

edited by

Touraj Ehtezazi

submission deadline 31 Oct 2024 | Viewed by 357 | Submission Open

Keywords: blood– brain barrier; drug delivery; brain diseases; neuroinflammation; remyelination

(This special issue belongs to the Section Pharmaceutical Technology)

Fluoroquinolones

edited by

Cecilia Bove

and

Nuno Manuel Xavier

submission deadline 31 Oct 2024 | Viewed by 311 | Submission Open

Keywords: fluoroquinolones; fluoroquinolone-associated disability; antibiotic safety; fluoroquinolone toxicity; antibiotic stewardship

(This special issue belongs to the Section Pharmacology)

DHA and EPA in Health and Disease

edited by

Anna Walczewska

Emilia Zgórzyńska

and

Katarzyna Wieczorek-Szukała

submission deadline 31 Oct 2024 | Viewed by 228 | Submission Open

Keywords: omega-3 polyunsaturated fatty acids; DHA; EPA; inflammation; oxidative stress; dietary supplements; cognitive decline; mental health; therapeutic strategies; cardiovascular diseases; hypertension; respiratory diseases

(This special issue belongs to the Section Pharmacology)

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