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Pharmaceuticals
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Organochalcogen Molecules and Materials in Medicinal Chemistry
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Organochalcogen Molecules and Materials in Medicinal Chemistry

A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Medicinal Chemistry".

Deadline for manuscript submissions: 25 October 2024 | Viewed by 1504

Special Issue Editors

Dr. Agata Pacuła-Miszewska

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Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 7 Gagarin Street, 87-100 Torun, Poland
Interests: organic synthesis; medicinal chemistry; asymmetric synthesis; organoselenium compounds
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jacek Ścianowski

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Guest Editor
Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 7 Gagarin Street, 87-100 Torun, Poland
Interests: organic synthesis; chalcogenides; terpenes, asymmetric synthesis; medicinal chemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The challenges in modern medicinal chemistry are related to the substantial problems of today's society. Environmental pollution, global warming, stress, and unhealthy lifestyles are among the factors that contribute to the development of widespread conditions such as cancer, diabetes, atherosclerosis, hypertension, depression, etc. The design of new molecules and bio-active materials for the prevention, treatment, and alleviation of diseases is a time-consuming process that, among other activities, includes the procurement and synthesis of new compounds and evaluations of their structure–activity relationships, pharmacokinetics, and bioavailability. Maximizing the activity and reducing the toxicity of a potential drug is crucial. However, the overall synthetic methodology, fulfilling the rules of green chemistry and economy, is also essential when considering specific large-scale production problems. Organochalcogen chemistry is significant in medicinal chemistry and modern organic synthesis, combining diversified biological and catalytical potential with a green chemistry perspective. In this Special Issue, we aim to collate innovative research articles and reviews that will present new biologically active sulfur-, selenium-, and tellurium-containing molecules and materials that facilitate the development of novel therapeutics and solutions for the current problems in chemical biology, material sciences, and medicine.

Dr. Agata Pacuła-Miszewska
Prof. Dr. Jacek Ścianowski
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • organochalcogen compounds
  • organochalcogen materials
  • modern synthetic protocols
  • biological activity

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Published Papers (2 papers)

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Research

14 pages, 1687 KiB  
Article
Antioxidative and Antiglycative Stress Activities of Selenoglutathione Diselenide
by Akiko Kanamori, Nana Egawa, Suyako Yamasaki, Takehito Ikeda, Marcia Juciele da Rocha, Cristiani Folharini Bortolatto, Lucielli Savegnago, César Augusto Brüning and Michio Iwaoka
Pharmaceuticals 2024, 17(8), 1049; https://doi.org/10.3390/ph17081049 - 9 Aug 2024
Viewed by 314
Abstract
The damage caused by oxidative and glycative stress to cells accumulates on a daily basis and accelerates aging. Glutathione (GSH), a major antioxidant molecule in living organisms, plays a crucial role in detoxifying the stress-causing substances inherent in cells, such as H2 [...] Read more.
The damage caused by oxidative and glycative stress to cells accumulates on a daily basis and accelerates aging. Glutathione (GSH), a major antioxidant molecule in living organisms, plays a crucial role in detoxifying the stress-causing substances inherent in cells, such as H2O2 and methylglyoxal (MG), an important intermediate of advanced glycation end-products (AGEs). In this study, we focused on the enhanced antioxidant capacity of the selenium analog of GSH, i.e., selenoglutathione (GSeH), compared to GSH, and examined its effects on the detoxification of stress-causing substances and improvement in cell viability. In cell-free systems, GSeH (1 mM) generated in situ from GSeSeG in the presence of NADPH and glutathione reductase (GR) rapidly reduced more than 80% of 0.1 mM H2O2, indicating the significant glutathione peroxidase (GPx)-like antioxidant activity of GSeSeG. Similarly, around 50% of 0.5 mM MG was degraded by 0.5 mM GSeH within 30 min through a non-enzymatic mechanism. It was also found that GSeSeG (0.05–0.5 mM) showed glutathione S-transferase (GST)-like activity against 1-chloro-2,4-dinitrobenzene (CDNB), a model substance of oxidative stress-causing toxic materials in cells. Meanwhile, HeLa cells that had been pre-treated with GSeSeG exhibited increased viability against 1.2 mM H2O2 (at [GSeSeG] = 0.5–50 μM) and 4 mM MG (at [GSeSeG] = 3 μM), and the latter effect was maintained for two days. Thus, GSeSeG is a potential antioxidant and antiglycative stress agent for cells. Full article
(This article belongs to the Special Issue Organochalcogen Molecules and Materials in Medicinal Chemistry)
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11 pages, 1199 KiB  
Article
The Influence of Long Carbon Chains on the Antioxidant and Anticancer Properties of N-Substituted Benzisoselenazolones and Corresponding Diselenides
by Agata J. Pacuła-Miszewska, Magdalena Obieziurska-Fabisiak, Aneta Jastrzębska, Angelika Długosz-Pokorska, Katarzyna Gach-Janczak and Jacek Ścianowski
Pharmaceuticals 2023, 16(11), 1560; https://doi.org/10.3390/ph16111560 - 4 Nov 2023
Cited by 1 | Viewed by 905
Abstract
Organoselenium compounds are well-known for their numerous biocapacities, which result from the uniqueness of the selenium atom and the possibility of constructing heterorganic molecules that can mimic the activity of selenoenzymes, crucial for a multitude of important physiological processes. In this paper, we [...] Read more.
Organoselenium compounds are well-known for their numerous biocapacities, which result from the uniqueness of the selenium atom and the possibility of constructing heterorganic molecules that can mimic the activity of selenoenzymes, crucial for a multitude of important physiological processes. In this paper, we have synthesized a series of N-substituted benzisoselenazolones and corresponding diphenyl diselenides possessing lipophilic long carbon chains, solely or with additional polar insets: phenyl linkers and ester groups. Evaluation of their antioxidant and cytotoxic activity revealed an increased H2O2-reduction potential of diphenyl diselenides bearing N-octyl, ethyl N-(12-dodecanoate)- and N-(8-octanoate) groups, elevated radical scavenging activity of 2,2′-diselenobis(N-dodecylbenzamide) and a promising cytotoxic potential of N-(4-dodecyl)phenylbenzisoselenazol-3(2H)-one. Full article
(This article belongs to the Special Issue Organochalcogen Molecules and Materials in Medicinal Chemistry)
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