Novel Therapeutic Approach to Inflammation and Pain

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 3074

Special Issue Editors


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Guest Editor
Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: polyphenols; natural products; NaDES; inflammation; oxidative stress
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Physiology and Pharmacology, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
2. Department of Biochemical Sciences, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
Interests: inflammation; pain; natural compounds; osteoarthritis; cellular pathways
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Inflammation and pain are two closely related issues that are often intricately linked in certain pathologies and are therefore frequently studied together in scientific research. It has been determined that they are interconnected by a complex signaling network based on a variety of molecules, receptors, and cellular pathways, which play fundamental roles in the onset and development of pathological conditions such as, for example, cancer, osteoarthritis, metabolic disorders, and autoimmune disease. However, although many advances have been made in this research field, the whole mechanisms responsible for inflammatory and painful signaling have not been fully clarified. Moreover, from a therapeutical perspective, currently available analgesic and anti-inflammatory drugs are often characterized by various side effects that limit their clinical administration. In this context, understanding these mechanisms and identifying new therapeutic targets would pave the way for new discoveries in the pharmaceutical field to provide innovative alternatives to inflammation and pain treatment. At the same time, it is important to discover and develop new molecules with increasingly minimal side effects.

In this Special Issue of Pharmaceutics, we invite authors to submit original research articles or reviews in the fields of pain and inflammation. Research areas may include (but are not limited to) the following topics:

  • Study of alternative targets or novel therapeutic strategies;
  • New pharmaceutical formulations;
  • Drug delivery systems as well as drug repositioning approaches.

Hoping for your active participation, we look forward to receiving your contributions.

Dr. Roberto Mattioli
Dr. Alessia Mariano
Guest Editors

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Keywords

  • inflammation
  • pain
  • chronical disease
  • drug repositioning
  • intracellular pathways
  • drug delivery systems
  • novel therapeutic strategies

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Published Papers (2 papers)

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Research

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23 pages, 4043 KiB  
Article
Development and Evaluation of Two-Phase Gel Formulations for Enhanced Delivery of Active Ingredients: Sodium Diclofenac and Camphor
by Giedre Kasparaviciene, Yuliia Maslii, Nataliia Herbina, Daiva Kazlauskiene, Mindaugas Marksa and Jurga Bernatoniene
Pharmaceutics 2024, 16(3), 366; https://doi.org/10.3390/pharmaceutics16030366 - 5 Mar 2024
Cited by 1 | Viewed by 1536
Abstract
The formulation of biphasic gels as potential semi-solid carriers for hydrophilic and lipophilic active substances is promising for the development of pharmaceutical preparations. The aim of this study was to design a stable bigel composition and to determine the influence of the organogel/hydrogel [...] Read more.
The formulation of biphasic gels as potential semi-solid carriers for hydrophilic and lipophilic active substances is promising for the development of pharmaceutical preparations. The aim of this study was to design a stable bigel composition and to determine the influence of the organogel/hydrogel ratio on the gel’s physical-chemical and structural-mechanical properties. The investigated compositions of organogel/hydrogel remained stable at ratios ranging from 5/95 to 40/60. After texture and microstructure analysis, bigels with 20/80 and 25/75 ratios were selected as carriers for the active ingredients, sodium diclofenac and camphor, for use as topical preparations for the treatment of muscle-joint inflammation and pain. Although other researchers have published data on the preparation and evaluation of bigels, there are no scientific results on the development of a two-phase gel with our proposed combination of APIs. Sodium diclofenac release was found to be higher when combined with camphor, which revealed the advantages of the biphasic formulation. The pseudoplastic behavior, thixotropy, and thermal stability of flow of the studied bigel samples was investigated by rheological analysis. Ongoing stability studies confirmed the minimal 6-month period. Full article
(This article belongs to the Special Issue Novel Therapeutic Approach to Inflammation and Pain)
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Review

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28 pages, 959 KiB  
Review
The Antinociceptive Role of Nrf2 in Neuropathic Pain: From Mechanisms to Clinical Perspectives
by Kestutis Petrikonis, Jurga Bernatoniene, Dalia M. Kopustinskiene, Roberto Casale, Sergio Davinelli and Luciano Saso
Pharmaceutics 2024, 16(8), 1068; https://doi.org/10.3390/pharmaceutics16081068 - 15 Aug 2024
Viewed by 780
Abstract
Neuropathic pain, a chronic condition resulting from nerve injury or dysfunction, presents significant therapeutic challenges and is closely associated with oxidative stress and inflammation, both of which can lead to mitochondrial dysfunction. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, a critical [...] Read more.
Neuropathic pain, a chronic condition resulting from nerve injury or dysfunction, presents significant therapeutic challenges and is closely associated with oxidative stress and inflammation, both of which can lead to mitochondrial dysfunction. The nuclear factor erythroid 2-related factor 2 (Nrf2) pathway, a critical cellular defense mechanism against oxidative stress, has emerged as a promising target for neuropathic pain management. Nrf2 modulators enhance the expression of antioxidant and cytoprotective genes, thereby reducing oxidative damage, inflammation, and mitochondrial impairment. This review explores the antinociceptive effects of Nrf2, highlighting how pharmacological agents and natural compounds may be used as potential therapeutic strategies against neuropathic pain. Although preclinical studies demonstrate significant pain reduction and improved nerve function through Nrf2 activation, several clinical challenges need to be addressed. However, emerging clinical evidence suggests potential benefits of Nrf2 modulators in several conditions, such as diabetic neuropathy and multiple sclerosis. Future research should focus on further elucidating the molecular role of Nrf2 in neuropathic pain to optimize its modulation efficacy and maximize clinical utility. Full article
(This article belongs to the Special Issue Novel Therapeutic Approach to Inflammation and Pain)
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