Stromal, Stem, Signaling Cells: The Multiple Roles and Applications of Mesenchymal Cells, 2nd Edition

Dear Colleagues,

The characterization of Mesenchymal Stem Cells (MSCs) has challenged scientists since their first discovery. Initially defined by their differentiation ability and markers expression in culture, MSCs were then been classified as the in vitro counterpart of perivascular cells. This discovery shed light on the existence of multiple sub-groups of MSCs, highly heterogenous and characterized by different abilities and molecular signatures. The in vivo regenerative potential of MSCs has been challenged by many studies, and it is nowadays widely recognized that this ability resides in their capacity to orchestrate the regenerative processes by releasing bioactive factors. In fact, from their isolation, MSCs have been the centre of numerous clinical studies focused on cell-based therapies for tissue regeneration.

This Special Issue is designed to give a comprehensive overview of the studies involving MSCs, together with the new knowledge about their possible use as drug delivery systems based on exosome secretion. In this regard, we would like to invite review articles which address the above-mentioned topics or original research papers providing new evidence on MSCs characterization and clinical application.

I look forward to reading your contributions.

Dr. Bianca Vezzani
Guest Editor

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