Nanocomposites as Implantable Devices or Drug Delivery Platforms: A New Insight into Treat Dental and Oral Diseases
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 19
Special Issue Editors
Interests: nanomaterials; drug delivery system; natural compound
Interests: ex-vivo permeation; nanosystems; drug delivery systems; biopolymers; buccal tablets; microparticles; dissolution kinetics
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Nanocomposites are multiphase materials where at least one component is in the nano-scale range. Due to their unique properties, they are currently spotlighted as versatile and innovative dosage forms. Specifically, their mechanical, physical, and chemical properties, biocompatibility, and adaptable composition could represent a new frontier in the local/loco-regional treatment of dental and oral diseases. Their multifunctional components could determine targeted drug delivery and co-administration of incompatible actives, offering innovative treatment options for periodontitis, oral lichen planus (OLP), medication-related osteonecrosis of the jaw (MRONJ), and oral cancers (e.g., OSCC). Nanocomposites can mitigate any systemic side effect by ensuring localized and controlled release of synthetic drugs and natural compounds with pronounced anti-inflammatory, antioxidant, anticancer, wound healing, antibiotic, and osteoinductive activities while improving treatment effectiveness and success. These results could be achieved by carefully designing the whole nanocomposite which could be used as such or as covering material for implantable devices (e.g., titanium-based) or bone substitutes (e.g., hydroxyapatite). Each component's accurate choice will lead to the desired characteristics, e.g., longevity, osteointegration, in situ solidification, mucoadhesion, controlled drug release, etc.
This Special Issue will cover all the advances, challenges, and future perspectives in using actives-loaded nanocomposites to manage dental and oral diseases. Literature reviews and research papers concerning developing nanocomposite-based innovative drug delivery systems (e.g., bone substitutes, covering materials, gingival patches of films, periodontal injectable in situ gelling matrices, etc.) are welcome.
We look forward to receiving your contributions.
Dr. Giuseppe Angellotti
Dr. Giulia Di Prima
Guest Editors
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Keywords
- dental implant
- covering materials
- bone substitutes
- scaffold
- antioxidant
- anti-inflammatory
- nanocomposite
- controlled release
- dental and oral diseases
- patches and films
- injectable in situ gelling formulations
- biocompatibility
- tissue regeneration
- anticancer
