Novel Controlled Release Drug Delivery Systems by Applying 3D Printing Technology

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (30 September 2021) | Viewed by 4460

Special Issue Editors


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Guest Editor
College of Pharmacy, Wonkwang University, Iksan, Jeonbuk 54538, Republic of Korea
Interests: pharmacokinetics; pharmacodynamics; modeling and simulation; 3D printing; controlled release formulations

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Guest Editor
School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi-do 16419, Republic of Korea
Interests: pharmacokinetics; translational PKPD modeling; PBPK modeling; in vitro–in vivo correlation; pharmaceutical analysis; 3D printing
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Special Issue Information

Dear Colleagues,

Since the first FDA approval of 3D printed tablet, there has been an emerging interest in the pharmaceutical application of 3D printing technology, or additive manufacturing. The unique advantages of 3D printing technology over conventional manufacturing have shown its potential to improve upon current pharmaceutical dosage forms through complex and customized dosage forms which are not cost-effective or otherwise impossible. In the last decades, therefore, 3D printing has been extensively explored and applied to design and develop innovative controlled release dosage forms.

In this Special Issue, we seek to highlight the advantages, key challenges, and future directions of the application of 3D printing technology for the development of novel controlled release drug delivery systems. Topics may include, but are not limited to, various innovative applications of 3D printing technology in controlled release dosage forms and drug delivery systems and their in vitro as well as in vivo evaluations. We look forward to your submission of original research work or review articles.

Prof. Soyoung Shin
Prof. Beom Soo Shin
Guest Editors

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Keywords

  • 3D printing
  • additive manufacturing
  • controlled release
  • oral dosage forms
  • drug delivery system
  • sustained release
  • gastroretentive system
  • in vitro test
  • in vivo pharmacokinetics

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Published Papers (1 paper)

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Research

22 pages, 19554 KiB  
Article
Three-Dimensional Printing of Curcumin-Loaded Biodegradable and Flexible Scaffold for Intracranial Therapy of Glioblastoma Multiforme
by Ruixiu Li, Yunmei Song, Paris Fouladian, Mohammad Arafat, Rosa Chung, Jarrod Kohlhagen and Sanjay Garg
Pharmaceutics 2021, 13(4), 471; https://doi.org/10.3390/pharmaceutics13040471 - 31 Mar 2021
Cited by 25 | Viewed by 3580
Abstract
A novel drug delivery system preventing Glioblastoma multiforme (GBM) recurrence after resection surgery is imperatively required to overcome the mechanical limitation of the current local drug delivery system and to offer personalised treatment options for GBM patients. In this study, 3D printed biodegradable [...] Read more.
A novel drug delivery system preventing Glioblastoma multiforme (GBM) recurrence after resection surgery is imperatively required to overcome the mechanical limitation of the current local drug delivery system and to offer personalised treatment options for GBM patients. In this study, 3D printed biodegradable flexible porous scaffolds were developed via Fused Deposition Modelling (FDM) three-dimensional (3D) printing technology for the local delivery of curcumin. The flexible porous scaffolds were 3D printed with various geometries containing 1, 3, 5, and 7% (w/w) of curcumin, respectively, using curcumin-loaded polycaprolactone (PCL) filaments. The scaffolds were characterised by a series of characterisation studies and in vitro studies were also performed including drug release study, scaffold degradation study, and cytotoxicity study. The curcumin-loaded PCL scaffolds displayed versatile spatiotemporal characteristics. The polymeric scaffolds obtained great mechanical flexibility with a low tensile modulus of less than 2 MPa, and 4 to 7-fold ultimate tensile strain, which can avoid the mechanical mismatch problem of commercially available GLIADEL wafer with a further improvement in surgical margin coverage. In vitro release profiles have demonstrated the sustained release patterns of curcumin with adjustable release amounts and durations up to 77 h. MTT study has demonstrated the great cytotoxic effect of curcumin-loaded scaffolds against the U87 human GBM cell line. Therefore, 3D printed curcumin-loaded scaffold has great promise to provide better GBM treatment options with its mechanical flexibility and customisability to match individual needs, preventing post-surgery GBM recurrence and eventually prolonging the life expectancy of GBM patients. Full article
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