Advances in Nano Drug Design and Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 6651

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa
Interests: phytochemistry; marine natural products; bioactivity; organic synthesis; metabolomics; in silico study; nanomaterial synthesis; drug delivery systems
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Guest Editor
Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, Pretoria 0208, South Africa
Interests: liposomes/niosomes; nano (co) crystals; nanofibers

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Guest Editor
Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Grahamstown 6140, South Africa
Interests: SLN; NLC; ocular drug delivery

Special Issue Information

Dear Colleagues,

Nano Drug delivery systems exhibit several advantages including but not limited to their ability to encapsulate a wide variety of therapeutic agents, including small molecules, peptides, proteins, genes, while also being able to control, tune and target drug release. Despite the commercialization of some nano drug delivery systems, newer technologies have been developed to fabricate nanomaterials more efficiently and in some instances with enhanced capabilities such as theranostic tools or active targeted nanocarriers/nanomaterials. These have subsequently found use in the treatment of several diseases such HIV/AIDS, cancer and immunological diseases.

The goal of this Special Issue is to showcase the current state-of-the-art and modern progress in the field of nano drug delivery. Suggested topics include: Manufacturing processes including challenges and industrial scale-up; regulatory approaches to nanodrug delivery systems including generic medicinal products; new approaches in targeted drug delivery; and nanoparticulate systems characterization techniques including imaging and theranostics.

Dr. Xavier Siwe Noundou
Dr. Witika Bwalya
Dr. Makoni Pedzisai
Guest Editors

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Keywords

  • liposomes
  • nanospheres
  • nanocrystals
  • nanosponges
  • solid lipid nanoparticles
  • nanofibers

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Published Papers (1 paper)

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Review

29 pages, 4688 KiB  
Review
Codelivery of Phytochemicals with Conventional Anticancer Drugs in Form of Nanocarriers
by Girish Kumar, Tarun Virmani, Ashwani Sharma and Kamla Pathak
Pharmaceutics 2023, 15(3), 889; https://doi.org/10.3390/pharmaceutics15030889 - 9 Mar 2023
Cited by 38 | Viewed by 5980
Abstract
Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various hurdles, such as drug resistance, insensitivity of cancer cells to drugs, adverse effects and patient inconveniences. Hence, plant-based [...] Read more.
Anticancer drugs in monotherapy are ineffective to treat various kinds of cancer due to the heterogeneous nature of cancer. Moreover, available anticancer drugs possessed various hurdles, such as drug resistance, insensitivity of cancer cells to drugs, adverse effects and patient inconveniences. Hence, plant-based phytochemicals could be a better substitute for conventional chemotherapy for treatment of cancer due to various properties: lesser adverse effects, action via multiple pathways, economical, etc. Various preclinical studies have demonstrated that a combination of phytochemicals with conventional anticancer drugs is more efficacious than phytochemicals individually to treat cancer because plant-derived compounds have lower anticancer efficacy than conventional anticancer drugs. Moreover, phytochemicals suffer from poor aqueous solubility and reduced bioavailability, which must be resolved for efficacious treatment of cancer. Therefore, nanotechnology-based novel carriers are employed for codelivery of phytochemicals and conventional anticancer drugs for better treatment of cancer. These novel carriers include nanoemulsion, nanosuspension, nanostructured lipid carriers, solid lipid nanoparticles, polymeric nanoparticles, polymeric micelles, dendrimers, metallic nanoparticles, carbon nanotubes that provide various benefits of improved solubility, reduced adverse effects, higher efficacy, reduced dose, improved dosing frequency, reduced drug resistance, improved bioavailability and higher patient compliance. This review summarizes various phytochemicals employed in treatment of cancer, combination therapy of phytochemicals with anticancer drugs and various nanotechnology-based carriers to deliver the combination therapy in treatment of cancer. Full article
(This article belongs to the Special Issue Advances in Nano Drug Design and Delivery)
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