Innovative Drug Delivery Systems for Enhanced Therapeutic Efficacy in Cancers, Liver Disease and Psoriasis

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: 20 April 2025 | Viewed by 563

Special Issue Editors


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Guest Editor
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Interests: hybrid nanoparticles; transferrin; matrix metalloproteinases; immunomodulator; chemoimmunotherapy
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Interests: drug delivery; cancer immunotherapy; cardiovascular disease; pharmaceutical science
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The F.M. Kirby Neurobiology Center, Boston Children’s Hospital and Harvard Medical School, Boston, MA 02115, USA
Interests: tissue regeneration

Special Issue Information

Dear Colleagues,

Recent data from the Global Burden of Disease (GBD) study on mortality and disability rates across countries indicate a rapidly increasing health and economic burden of cancers and liver disease in many parts of the world. Interestingly, researchers have found that patients with psoriasis had an increased risk of developing cancers, including colon, kidney, and liver cancers, etc. In addition, patients with severe psoriasis and developed cancer also had an increased overall risk of dying.

This Special Issue aims to explore the latest advancements in the drug delivery system and biopharmaceuticals specifically targeting cancers, liver disease, and psoriasis. The focus will be on innovative approaches, mechanisms of action, and clinical outcomes related to these therapies in challenging cancers, liver disease, and psoriasis. By providing a platform for original research articles and comprehensive reviews, this Special Issue seeks to foster a deeper understanding of the potential and limitations of drugs in these diseases, ultimately contributing to improved therapeutic strategies and patient outcomes.

In this Special Issue, we aim to collect submissions that focus on the drug delivery Systems for Enhanced Therapeutic Efficacy in cancers, liver disease, and psoriasis. Original research articles and reviews, including in vitro and in vivo evidence and clinical data, are welcome.

Dr. Xiaofei Xin
Dr. Lisha Liu
Dr. Yunfan Kong
Guest Editors

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Keywords

  • drug delivery
  • lipid nanoparticles
  • liposomes
  • exosomes
  • long-acting injections
  • topical delivery
  • supermolecules
  • hydrogel
  • nucleic acid therapeutics
  • gene-editing therapeutics
  • small molecules
  • monoclonal antibody
  • cell-based therapy
  • biopharmaceuticals

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Published Papers (1 paper)

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Research

22 pages, 3597 KiB  
Article
Enhanced Antitumor Efficacy of Cytarabine and Idarubicin in Acute Myeloid Leukemia Using Liposomal Formulation: In Vitro and In Vivo Studies
by Chunxia Zhu, Yang Liu, Xiaojun Ji, Yaxuan Si, Xianhao Tao, Xiaohua Zhang and Lifang Yin
Pharmaceutics 2024, 16(9), 1220; https://doi.org/10.3390/pharmaceutics16091220 - 19 Sep 2024
Viewed by 375
Abstract
Background: Acute myeloid leukemia (AML) is the most common type of acute leukemia among adults with the recommend therapy of combination of cytarabine and idarubicin in the induction phase. The uncoordinated pharmacokinetics prevent adequate control of drug ratio following systemic administration. Therefore, the [...] Read more.
Background: Acute myeloid leukemia (AML) is the most common type of acute leukemia among adults with the recommend therapy of combination of cytarabine and idarubicin in the induction phase. The uncoordinated pharmacokinetics prevent adequate control of drug ratio following systemic administration. Therefore, the dual-loaded liposomes containing cytarabine and idarubicin for synergistic effects were proposed and investigated. Methods: The molar ratio of cytarabine and idarubicin for synergistic effects was investigated. The dual-loaded liposomes were prepared and characterized by particle size, zeta potential, encapsulation efficiency, cryo-Transmission electron microscopy (cryo-TEM), and in vitro stability. The in vitro cytotoxicity and cell uptake of liposomes were determined within CCRF-CEM cells. The PK experiments was carried out in male SD rats. The in vivo antitumor effect was carried out within CD-1 nude female mice. The antitumor mechanism of liposomes was investigated. Results: The synergistic molar ratios were found to be in the range of 20:1~40:1. The size distribution of the dual-loaded liposomes was approximately 100 nm with PDI ≤ 0.1, a zeta potential of approximately −30 mV, an entrapment efficiency of cytarabine and idarubicin of >95% with spherical structure and uniform distribution, and in vitro stability for 21 d. The drugs in the liposomes can be quickly uptaken by the leukemia cells. The PK experiments showed that the molar ratio of cytarabine to idarubicin in plasma was maintained at 30:1 within 4 h. The efficacy of liposomes was significantly enhanced. Conclusions: The dual-loaded liposomes containing cytarabine and idarubicin showed enhanced antitumor efficacy. Full article
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