New Insights into Cyclodextrin-Based Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 322

Special Issue Editors


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Guest Editor
Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary
Interests: cyclodextrins; cellular effects of cyclodextrins; drug delivery; pharmaceutical technology; innovative dosage froms; RNA therapy

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Guest Editor
Department of Molecular and Nanopharmaceutics, Faculty of Pharmacy, University of Debrecen, H-4002 Debrecen, Hungary
Interests: cyclodextrins; host-guest complexation; drug delivery; biological barriers; cellular effects of cyclodextrins; pharmacokinetics and tissue distribution of cyclodextrins
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Special Issue Information

Dear Colleagues,

In recent decades, the biomedical and pharmaceutical potential of cyclodextrins has expanded remarkably. Their well‑established host–guest complexation ability continues to play a key role in enhancing the solubility and therefore the bioavailability of poorly soluble, lipophilic small‑molecules. At the same time, cyclodextrins and their polymeric derivatives have increasingly been applied in the formulation of larger biomolecules, including peptides and nucleic acids.

Beyond their formulation benefits, the intrinsic biological activities of cyclodextrins have become an area of growing scientific interest. Far from being inactive excipients, these molecules exhibit properties that may be harnessed in diverse biomedical contexts, such as infectious disease research, cardiovascular therapy, and the study of cholesterol‑associated neurodegenerative disorders.

This Special Issue aims to present the latest advances in cyclodextrin‑based delivery systems, covering host–guest interactions, innovative dosage forms, and emerging insights into their biological effects. We welcome reviews and original research articles.

Dr. Ágnes Rusznyák
Dr. Ferenc Fenyvesi
Guest Editors

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Keywords

  • cyclodextrins
  • cyclodextrin-based therapeutics
  • drug delivery
  • host–guest interaction
  • cyclodextrin-based innovative dosage forms
  • biological effects of cyclodextrins

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Published Papers (1 paper)

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Review

36 pages, 1993 KB  
Review
Cyclodextrin-Based Strategies for Brain Drug Delivery: Mechanistic Insights into Blood–Brain Barrier Transport and Therapeutic Applications
by Pirscoveanu Denisa Floriana Vasilica, Pluta Ion Dorin, Carmen Vladulescu, Cristina Popescu, Diana-Maria Trasca, Kristina Radivojevic, Renata Maria Varut, Ștefănița Bianca Vintilescu, Mioara Desdemona Stepan and George Alin Stoica
Pharmaceutics 2026, 18(4), 451; https://doi.org/10.3390/pharmaceutics18040451 - 7 Apr 2026
Abstract
Cyclodextrins (CDs) have gained increasing attention as versatile platforms for enhancing drug delivery to the central nervous system, particularly in overcoming the restrictive properties of the blood–brain barrier (BBB). Owing to their unique cyclic oligosaccharide structure, CDs are capable of forming inclusion complexes [...] Read more.
Cyclodextrins (CDs) have gained increasing attention as versatile platforms for enhancing drug delivery to the central nervous system, particularly in overcoming the restrictive properties of the blood–brain barrier (BBB). Owing to their unique cyclic oligosaccharide structure, CDs are capable of forming inclusion complexes with a wide range of therapeutic agents, thereby improving their solubility, stability, and bioavailability. In addition to their role as excipients, growing evidence indicates that CDs can actively modulate biological processes, including membrane fluidity and cholesterol homeostasis, which are critical factors in neurological disorders. This review explores the application of CDs in facilitating drug transport across the BBB through multiple mechanisms, including carrier-mediated transport, receptor-mediated transcytosis, and nanoparticle-based delivery systems. Special emphasis is placed on their use in the treatment of neurodegenerative and neurological diseases, such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, Niemann–Pick type C disease, and other central nervous system disorders. In these contexts, CD-based formulations have demonstrated the ability to enhance brain targeting, reduce pathological protein aggregation, and improve therapeutic outcomes in preclinical models. This review uniquely integrates cyclodextrin’s physicochemical properties with specific blood–brain barrier transport mechanisms, proposing a structure–transport–therapy framework that enables a more predictive understanding of brain-targeted drug delivery. Full article
(This article belongs to the Special Issue New Insights into Cyclodextrin-Based Drug Delivery Systems)
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