Cyclodextrins and Their Pharmaceutical Applications
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 20 January 2025 | Viewed by 65
Special Issue Editors
Interests: cyclodextrins; solubilization; stabilization; prodrugs; soft drugs; ophtalmic drug delivery
Special Issue Information
Dear Colleagues,
We are pleased to invite you to contribute to our Special Issue on "Cyclodextrins and Their Pharmaceutical Applications". This Special Issue aims to compile cutting-edge research and comprehensive reviews that explore the multifaceted roles of cyclodextrins in modern medicine. We seek contributions that highlight recent advancements, address current challenges, and propose future directions for the application of cyclodextrins in pharmaceuticals. The potential of cyclodextrins in pharmaceuticals was first recognized several decades ago, and since then, their use has expanded exponentially. These compounds have proven to be invaluable in improving the pharmacokinetic profiles of numerous drugs, particularly those with poor water solubility. By forming inclusion complexes, cyclodextrins can protect labile drugs from degradation, control the release rate of active pharmaceutical ingredients, and reduce drug volatility and odor. Such modifications not only enhance therapeutic efficacy but also improve patient compliance and safety. Beyond traditional drug delivery, cyclodextrins have shown promise in advanced therapeutic applications, including gene delivery, targeted cancer therapy, and the treatment of neurodegenerative diseases. Their biocompatibility and relatively low toxicity make them suitable for a wide range of biomedical applications. Furthermore, recent advancements in the chemical modification of cyclodextrins have opened new avenues for creating more specific and efficient drug delivery systems. The importance of cyclodextrin research lies in its potential to revolutionize the pharmaceutical industry. With ongoing innovations in synthesis, functionalization, and application, cyclodextrins continue to offer novel solutions for drug delivery challenges. Current research focuses on understanding the interactions at the molecular level, optimizing cyclodextrin-based formulations, and exploring new therapeutic targets.
This Special Issue aims to present a collection of innovative research and in-depth reviews that explore the various applications of cyclodextrins in the realm of modern pharmaceutical science. We are looking for submissions that demonstrate cutting-edge developments, tackle pressing issues, and provide forward-looking insights into the potential uses of cyclodextrins in drug development and delivery, including the following:
- Innovative methods for the synthesis and characterization of cyclodextrin complexes;
- The role of cyclodextrins in improving drug solubility and stability;
- Applications of cyclodextrins in targeted drug delivery systems;
- Clinical and preclinical studies demonstrating the efficacy of cyclodextrin-based formulations;
- Safety and toxicological evaluations of cyclodextrins in pharmaceutical applications, including regulatory status;
- Novel cyclodextrin derivatives;
- Cyclodextrins as APIs.
We look forward to receiving your contributions.
Prof. Dr. Thorsteinn Loftsson
Dr. Renata Maria Văruț
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- cyclodextrin complexes
- drug delivery systems
- pharmaceutical applications
- solubility enhancement
- therapeutic efficacy
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