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Pharmaceutics
Special Issues
Mesoporous Materials for Biomedical Application
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Mesoporous Materials for Biomedical Application

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 6954

Special Issue Editor

Dr. Cristina Nistor

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Guest Editor
Polymer Department, National Institute for Research and Development in Chemistry and Petrochemistry-ICECHIM, 060021 Bucharest, Romania
Interests: polymer composites; nanomaterials; nanostructured composites; nanoparticles; coatings; biomaterials; polymer science; sol-gel
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Mesoporous materials, especially those made of silica, are capturing great interest in the field of nanomedicine, and are intended for both systemic delivery systems and implantable local-delivery devices. In general, mesoporous materials are derived from supramolecular assemblies of surfactants, which template the inorganic component during synthesis. After the surfactant is removed, commonly by pyrolysis or dissolution with the appropriate solvent, the mesoporous matrices are potential drug carriers. Due to their unique pore size, higher surface area and pore volume, mesoporous materials have been widely employed as carriers for controlled drug delivery.

This Special Issue of Pharmaceutics is therefore dedicated to the most recent advances regarding the use of mesoporous materials in the field of biomedical applications.

Given your interesting work on the theme and related disciplines, I personally invite you and your colleagues to contribute either an original research paper or a review, to be published as an invited feature paper to this Special Issue. Research areas may include (but are not limited to) the following: devices based on mesoporous materials related to drugs and drug delivery; controlled-release mesoporous materials for drugs and (bio)pharmaceuticals; nanomedicine; drug targeting; and pharmaceutical formulation.

I look forward to receiving your contributions.

Dr. Cristina Nistor
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mesoporous materials
  • drug delivery
  • drug nanocarriers
  • mesoporous nanoparticles
  • biocompatible materials
  • controlled drug delivery formulations
  • porosity

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Published Papers (3 papers)

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Research

17 pages, 8987 KiB  
Article
Plant-Derived Nanocellulose with Antibacterial Activity for Wound Healing Dressing
by Gabriela Mădălina Oprică, Denis Mihaela Panaitescu, Brînduşa Elena Lixandru, Catalina Diana Uşurelu, Augusta Raluca Gabor, Cristian-Andi Nicolae, Radu Claudiu Fierascu and Adriana Nicoleta Frone
Pharmaceutics 2023, 15(12), 2672; https://doi.org/10.3390/pharmaceutics15122672 - 25 Nov 2023
Cited by 4 | Viewed by 1906
Abstract
The medical sector is one of the biggest consumers of single-use materials, and while the insurance of sterile media is non-negotiable, the environmental aspect is a chronic problem. Nanocellulose (NC) is one of the safest and most promising materials that can be used [...] Read more.
The medical sector is one of the biggest consumers of single-use materials, and while the insurance of sterile media is non-negotiable, the environmental aspect is a chronic problem. Nanocellulose (NC) is one of the safest and most promising materials that can be used in medical applications due to its valuable properties like biocompatibility and biodegradability, along with its good mechanical properties and high water uptake capacity. However, NC has no bactericidal activity, which is a critical need for the effective prevention of infections in chronic diabetic wound dressing applications. Therefore, in this work, a natural product, propolis extract (PE), was used as an antibacterial agent, in different amounts, together with NC to obtain sponge-like structures (NC/PE). The scanning electron microscope (SEM) images showed well-impregnated cellulose fibers and a more compact structure with the addition of PE. According to the thermogravimetric analysis (TGA), the samples containing PE underwent thermal degradation before the unmodified NC due to the presence of volatile compounds in the extract. However, the peak degradation temperature in the first derivative thermogravimetric curves was higher for all the sponges containing PE when compared to the unmodified NC. The antibacterial efficacy of the samples was tested against Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia coli, as well as on two clinically resistant isolates. The samples completely inhibited the development of Staphylococcus aureus, and Pseudomonas aeruginosa was partially inhibited, while Escherichia coli was resistant to the PE action. Considering the physical and biological properties along with the environmental and economic benefits, the development of an NC/PE wound dressing seems promising. Full article
(This article belongs to the Special Issue Mesoporous Materials for Biomedical Application)
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24 pages, 4725 KiB  
Article
Synergistic Sustained Drug-Release System Based on Immobilized Rhamnus frangula L. Phytoextract into Layered Double Hydroxide Covered by Biocompatible Hydrogel
by Ana-Lorena Neagu, Anamaria Zaharia, Octavian Dumitru Pavel, Alina Tîrşoaga, Iulia Elena Neblea, Sorin Viorel Dolana, Carmen Elena Ţebrencu, Tanta-Verona Iordache, Andrei Sârbu and Rodica Zăvoianu
Pharmaceutics 2023, 15(7), 1888; https://doi.org/10.3390/pharmaceutics15071888 - 5 Jul 2023
Cited by 1 | Viewed by 1575
Abstract
This work focuses on the synergetic effect obtained by immobilization of Rhamnus frangula L. (RfL) phytoextract in layered double hydroxides (LDHs) matrixes and their subsequent encapsulation into biocompatible hydrogels (HG). In this respect, the LDHs were used as hosts for the immobilization of [...] Read more.
This work focuses on the synergetic effect obtained by immobilization of Rhamnus frangula L. (RfL) phytoextract in layered double hydroxides (LDHs) matrixes and their subsequent encapsulation into biocompatible hydrogels (HG). In this respect, the LDHs were used as hosts for the immobilization of the phytoextract by a reconstruction method, after which the LDHsRfL were embedded into biocompatible hydrogel (HG) matrixes, based on polyethylene glycol diacrylate (PEGDA), by a radical polymerization reaction. The resulted biocompatible hydrogel composites were characterized by modern methods, while the swelling and rheology measurements revealed that the HG composites steadily improved as the content of RfL phytoextract immobilized on LDHs (LDHsRfL) increased. The following in vitro sustained release of the RfL phytoextract was highlighted by measurements at pH 6.8, in which case the composite HGs with LDHsRfL presented an improved release behavior over the LDHsRfL, thus, underlining the synergistic effect of PEGDA network and LDH particles on the slow-release behavior. The kinetic models used in the RfL release from composite HGs clearly indicate that the release is diffusion controlled in all the cases. The final composite HGs described here may find applications in the pharmaceutical field as devices for the controlled release of drugs. Full article
(This article belongs to the Special Issue Mesoporous Materials for Biomedical Application)
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16 pages, 3321 KiB  
Article
Kinetics and Mechanism of Camptothecin Release from Transferrin-Gated Mesoporous Silica Nanoparticles through a pH-Responsive Surface Linker
by Nicolás Jackson, Andrea C. Ortiz, Alejandro Jerez, Javier Morales and Francisco Arriagada
Pharmaceutics 2023, 15(6), 1590; https://doi.org/10.3390/pharmaceutics15061590 - 25 May 2023
Cited by 9 | Viewed by 2767
Abstract
Stimuli-responsive nanomaterials have emerged as a promising strategy for inclusion in anticancer therapy. In particular, pH-responsive silica nanocarriers have been studied to provide controlled drug delivery in acidic tumor microenvironments. However, the intracellular microenvironment that the nanosystem must face has an impact on [...] Read more.
Stimuli-responsive nanomaterials have emerged as a promising strategy for inclusion in anticancer therapy. In particular, pH-responsive silica nanocarriers have been studied to provide controlled drug delivery in acidic tumor microenvironments. However, the intracellular microenvironment that the nanosystem must face has an impact on the anticancer effect; therefore, the design of the nanocarrier and the mechanisms that govern drug release play a crucial role in optimizing efficacy. Here, we synthesized and characterized mesoporous silica nanoparticles with transferrin conjugated on their surface via a pH-sensitive imine bond (MSN-Tf) to assess camptothecin (CPT) loading and release. The results showed that CPT-loaded MSN-Tf (MSN-Tf@CPT) had a size of ca. 90 nm, a zeta potential of −18.9 mV, and a loaded content of 13.4%. The release kinetic data best fit a first-order model, and the predominant mechanism was Fickian diffusion. Additionally, a three-parameter model demonstrated the drug-matrix interaction and impact of transferrin in controlling the release of CPT from the nanocarrier. Taken together, these results provide new insights into the behavior of a hydrophobic drug released from a pH-sensitive nanosystem. Full article
(This article belongs to the Special Issue Mesoporous Materials for Biomedical Application)
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