Recent Advances in Pharmaceutical Applications of Functionalized Polysaccharides and Their Derivatives, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 30 April 2025 | Viewed by 1259

Special Issue Editors


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Guest Editor
Department of Chemical and Pharmaceutical Sciences, Kingston University London, Kingston upon Thames KT1 2EE, UK
Interests: polymer chemistry; inorganic materials chemistry; organic electronics and optoelectronics; nanomaterials; drug delivery; polymer characterization and surface modification; battery materials and systems
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Guest Editor
School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston upon Thames KT1 2EE, UK
Interests: drug delivery; biotechnology; biochemistry
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Kingston upon Thames KT1 2EE, UK
Interests: drug delivery; polymeric nanoparticles; inhalation therapy; boron neutron capture therapy; wound management; synthesis of new antimicrobial agents; formulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Several polysaccharides, including chitosan and alginate, have been used for a diverse range of biomedical applications due to their advantageous characteristics, such as biocompatibility, biodegradability, and low immunogenicity. Such uses include tissue-engineering scaffolds, pharmaceutical preparations, drug delivery, imaging, and prosthetics. Furthermore, chemical modification of these materials has led to new synthetic materials capable of enhancing the physical and chemical performance of their predecessors, for example, drug loading and uptake, drug targeting, and improved mechanical properties.

For this Special Issue, we are inviting submissions exploring novel trends and evaluations of the use of modified and non-modified polysaccharides in biomedical applications. Contributions may focus on single polymers or co-polymers and the integration of active pharmaceutical ingredients into hydrogels or polysaccharide nanocarriers. Potential topics of interest include, but are not limited to, the anti-microbial activity, wound management capabilities, and anti-cancer activity of these hydrogels/nanocarriers. Original research manuscripts and literature reviews are both welcome.

Prof. Dr. Peter Foot
Dr. Elena Polycarpou
Dr. Federico Buonocore
Guest Editors

Manuscript Submission Information

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Keywords

  • functionalized polysaccharides 
  • nanoparticle characterization
  • drug delivery
  • enhanced loading capacity
  • controlled release properties
  • anti-microbial and anti-cancer activities
  • wound management

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Published Papers (1 paper)

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Review

14 pages, 2267 KiB  
Review
The Potential Role of Plant Polysaccharides in Treatment of Ulcerative Colitis
by Yilizilan Dilixiati, Adila Aipire, Ming Song, Dilaram Nijat, Abudukahaer Wubuli, Qi Cao and Jinyao Li
Pharmaceutics 2024, 16(8), 1073; https://doi.org/10.3390/pharmaceutics16081073 - 16 Aug 2024
Viewed by 859
Abstract
Ulcerative colitis (UC) results in inflammation and ulceration of the colon and the rectum’s inner lining. The application of herbal therapy in UC is increasing worldwide. As natural macromolecular compounds, polysaccharides have a significant role in the treatment of UC due to advantages [...] Read more.
Ulcerative colitis (UC) results in inflammation and ulceration of the colon and the rectum’s inner lining. The application of herbal therapy in UC is increasing worldwide. As natural macromolecular compounds, polysaccharides have a significant role in the treatment of UC due to advantages of better biodegradation, good biocompatibility, immunomodulatory activity, and low reactogenicity. Therefore, polysaccharide drug formulation is becoming a potential candidate for UC treatment. In this review, we summarize the etiology and pathogenesis of UC and the therapeutic effects of polysaccharides on UC, such as regulating the expression of cytokines and tight junction proteins and modulating the balance of immune cells and intestinal microbiota. Polysaccharides can also serve as drug delivery carriers to enhance drug targeting and reduce side effects. This review provides a theoretical basis for applying natural plant polysaccharides in the prevention and treatment of UC. Full article
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