Biological Barrier-Specific Drug Delivery Designs
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".
Deadline for manuscript submissions: closed (30 November 2020) | Viewed by 5627
Special Issue Editors
Interests: drug–membrane interactions; cellular membrane biophysics; drug delivery systems for targeted delivery
Interests: medicinal chemistry; infectious, inflammatory and cancer diseases; nanotechnology and nanodelivery; development of “smart” drug systems; biophysics and drug-membrane interactions
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Collegues,
At present, there is an increasing research effort for the development of more efficient therapies able to target and deliver bioactive compounds or drug molecules to specific sites. The strategies behind it aim at the reduction of off-target effects and an enhanced efficacy while reducing the concentration of active molecules. There are many hurdles in this path, and probably the major challenge lays on crossing the biological barriers that are indispensable for the integrity and function of many human organs. Further, most of the time, bioactive compound pharmacodynamics and pharmacokinetics are affected by their interaction with physiological barriers. Indeed, bioactive compounds, drugs, and nanoparticles need to cross biological barriers to reach their target and, in some cases, act at the barrier level.
In this context, this issue aims to gather new strategies and approaches to target, cross or act in different body barriers such as skin, lung, gastrointestinal, and blood brain barriers, mouth and nasal mucosas, and cellular membranes. Furthermore, and once biological barriers are not exclusively from the body, drug delivery systems aiming at biofilms are also included. In this field, the development of in vitro, ex vivo, and in vivo models and visualization tools for the assessment of delivery system interaction with the barriers are also key.
Dr. Cláudia Nunes
Prof. Salette Reis
Guest Editors
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Keywords
- drug transport across barriers
- uptake mechanisms
- nanosystems
- targeted delivery
- pharmaceutical quality by design
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