Recent Progress in Solid Dispersion Technology, 3rd Edition
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 10 January 2025 | Viewed by 2098
Special Issue Editor
Interests: solid dispersion; supersaturation; molecular assemblies; poorly soluble drugs; thermal analysis; polymorphism; solubilization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For over half a century, amorphous solid dispersion (ASD) has been recognized as a powerful formulation technology for improving the oral absorption of poorly soluble drugs. Despite this long history, novel important findings on ASD continue to be reported every year. In contrast to other solubilization technologies using additives, including surfactants, cyclodextrins, and organic solvents, which increase equilibrium solubility, amorphization does not disturb the membrane permeation process. Thus, the probability of success in the improvement of oral absorption is considered generally high for ASD. In 2019, a Special Issue entitled “Recent Progress in Solid Dispersion Technology” was published to cover the cutting-edge research in this field, followed by the 2nd edition in 2021. We have decided to publish the 3rd edition to keep up with the new knowledge and technologies that have since emerged in ASD research.
This Special Issue welcomes any topics regarding recent progress in ASD technology, including, but not limited to the following:
- Prediction of oral absorption of drugs via ASD;
- Prediction of long-term storage stability of ASD;
- Relationship between a compound’s property and its suitability for ASD;
- How to maintain supersaturated drug concentration after the dissolution of ASD;
- Relevance of liquid–liquid phase separation to oral absorption;
- Novel manufacturing technologies involving ASD;
- Novel functional carriers for ASD;
- Novel analysis technologies for ASD.
Dr. Kohsaku Kawakami
Guest Editor
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Keywords
- amorphous
- solid dispersion
- poorly soluble drug
- supersaturation
- liquid–liquid phase separation
- crystallization
- stability
- spray-drying
- hot-melt extrusion
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