Smart Drug Targeting for Tumor Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1918

Special Issue Editor


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Guest Editor
Department of Microbiology, Immunology and Genetics, University of North Texas Health Science Center, Fort Worth, TX, USA
Interests: nanomedicine; nanotechnology; nanoparticles; biomaterials; nano/microparticle technologies; drug delivery systems; membrane clocked nanoparticle; exosome; micelle; liposome; sustained release; PLGA nanoparticle

Special Issue Information

Dear Colleagues,

Smart drug targeting for tumor therapy represents a promising approach that seeks to enhance the efficacy of cancer treatment while minimizing harm to healthy tissues. This field is rapidly advancing, utilizing nanotechnology and advanced drug delivery systems to selectively transport therapeutic agents to tumor cells. Researchers aim to enhance treatment effectiveness, diminish side effects, and overcome drug resistance in cancer therapy through active and passive targeting mechanisms and strategies for stimuli-responsive drug release. The continuous progress in this area holds significant potential for the future development of more efficient and personalized cancer treatments.

This Special Issue of Pharmaceutics aims to publish research and review papers encompassing recent developments and findings on all topics related to smart drug targeting for tumor therapy. Therefore, this issue covers all various practical aspects of drug targets for cancer therapy, but is not limited to including novel materials for targeting or developing drug delivery systems such as membrane-based, micelle, exosome-based, liposome, or polymeric nanoparticles, as well as the incorporation of stimuli-responsive drug release systems.

Dr. Amalendu P. Ranjan
Guest Editor

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Keywords

  • nanomedicine
  • nanotechnology
  • nanoparticles
  • biomaterials
  • nano/microparticle technologies
  • drug delivery systems
  • membrane clocked nanoparticle
  • exosome
  • micelle
  • liposome
  • sustained release
  • PLGA nanoparticle

Published Papers (1 paper)

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Review

15 pages, 4443 KiB  
Review
Immunoengineering via Chimeric Antigen Receptor-T Cell Therapy: Reprogramming Nanodrug Delivery
by Theodora Katopodi, Savvas Petanidis, Doxakis Anestakis, Charalampos Charalampidis, Ioanna Chatziprodromidou, George Floros, Panagiotis Eskitzis, Paul Zarogoulidis, Charilaos Koulouris, Christina Sevva, Konstantinos Papadopoulos, Marios Dagher, Nikolaos Varsamis, Vasiliki Theodorou, Chrysi Maria Mystakidou, Nikolaos Iason Katsios, Konstantinos Farmakis and Christoforos Kosmidis
Pharmaceutics 2023, 15(10), 2458; https://doi.org/10.3390/pharmaceutics15102458 - 13 Oct 2023
Viewed by 1593
Abstract
Following its therapeutic effect in hematological metastasis, chimeric antigen receptor (CAR) T cell therapy has gained a great deal of attention during the last years. However, the effectiveness of this treatment has been hampered by a number of challenges, including significant toxicities, difficult [...] Read more.
Following its therapeutic effect in hematological metastasis, chimeric antigen receptor (CAR) T cell therapy has gained a great deal of attention during the last years. However, the effectiveness of this treatment has been hampered by a number of challenges, including significant toxicities, difficult access to tumor locations, inadequate therapeutic persistence, and manufacturing problems. Developing novel techniques to produce effective CARs, administer them, and monitor their anti-tumor activity in CAR-T cell treatment is undoubtedly necessary. Exploiting the advantages of nanotechnology may possibly be a useful strategy to increase the efficacy of CAR-T cell treatment. This study outlines the current drawbacks of CAR-T immunotherapy and identifies promising developments and significant benefits of using nanotechnology in order to introduce CAR transgene motifs into primary T cells, promote T cell expansion, enhance T cell trafficking, promote intrinsic T cell activity and rewire the immunosuppressive cellular and vascular microenvironments. Therefore, the development of powerful CART cells can be made possible with genetic and functional alterations supported by nanotechnology. In this review, we discuss the innovative and possible uses of nanotechnology for clinical translation, including the delivery, engineering, execution, and modulation of immune functions to enhance and optimize the anti-tumor efficacy of CAR-T cell treatment. Full article
(This article belongs to the Special Issue Smart Drug Targeting for Tumor Therapy)
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