New Therapeutic Approaches for the Application of Natural Products in Skin Diseases

Dear Colleagues,

Recent advancements in the field of dermatology have introduced innovative therapeutic strategies for managing skin diseases, focusing on improved treatment efficacy and drug delivery. The growing interest in the use of natural products for skin diseases has sparked therapeutic advancements aimed at overcoming bioavailability and stability issues, with a focus on evidence-based applications of phytochemicals for safe, multi-targeted treatment of chronic conditions like eczema, psoriasis, and acne. Advanced technologies such as microneedle patches, transdermal systems, and nano-delivery methods enable precise drug administration, while nanocarriers, such as liposomes and polymeric nanoparticles, enhance stability and bioavailability of encapsulated active compounds bypassing the limitations of traditional topical applications. Emerging sources of therapeutics, such as extracellular vesicle-based therapies, are increasingly being explored as non-invasive tools for delivering regenerative factors directly to damaged skin. These innovations collectively pave the way for more effective and patient-friendly treatments for skin diseases.

This Special Issue aims to showcase original research and review articles that contribute to advancing current knowledge in areas including, but not limited to, the following:

• In vitro and in vivo evidence of natural products' activities in modulating skin disorders;
• Identification of individual compounds responsible for skin health benefits and molecular docking analysis;
• Transdermal/topical delivery systems with natural products for skin conditions;
• Pharmaceutical skin formulations based on nanocarriers such as liposomes, nano-capsules, and polymeric nanoparticles containing natural products for skin conditions;
• Use of extracellular vesicles in the treatment of skin diseases;
• Regenerative therapies for skin diseases;
• Clinical trials with natural product treatment of dermatological conditions.

Dr. Andrea Pirković
Dr. Aleksandra A. Jovanović
Dr. Dragana Dekanski
Guest Editors

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