Application of Metal-Based Complexes in Cancer Treatment

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 2409

Special Issue Editors


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Guest Editor
Facultad de Quimica, Universidad Nacional Autónoma de México, Mexico City, Mexico
Interests: metallodrugs; cancer; activity descriptors; tropical neglected diseases

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Guest Editor
Facultad de Ciencias Naturales, Universidad Autónoma de Querétaro, Campus Juriquilla C.P. 76230, Querétaro, Mexico
Interests: cancer; apoptosis; molecular biology; cellular biology; action mechanism

Special Issue Information

Dear Colleagues,

We pleased to invite you to a Special Issue of Pharmaceutics (MDPI) entitled “Application of Metal-Based Complexes in Cancer Treatment”. The aim of this Special Issue is to compile the most recent innovative approaches on metallodrugs that include the design of new molecules with particular properties that may improve cancer treatment. The manuscripts can present studies of new targets, mechanisms of action, molecular and cellular studies, omics advances and differential gene expression, among other mechanisms. High-quality original research articles and reviews are welcome. Any approach to improve cancer treatment with a special type of formulation in order to preserve the activity of metallodrugs for cancer treatment is of interest. Research areas of this SI may include (but are not limited to) the following:

  1. Adult tumors;
  2. Child tumors;
  3. Essential metals;
  4. Non-essential metals.

We look forward to receiving your contributions.

Prof. Dr. Lena Ruíz-Azuara
Prof. Dr. Carmen Mejía
Guest Editors

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Keywords

  • metallodrugs
  • mechanism of action
  • targets
  • pharmaceutical formulation

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Published Papers (2 papers)

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Research

26 pages, 7005 KiB  
Article
L-Citrullinato-Bipyridine and L-Citrullinato-Phenanthroline Mixed Copper Complexes: Synthesis, Characterization and Potential Anticancer Activity
by Diego Ramírez-Contreras, Sergio Vázquez-Rodríguez, Amalia García-García, Lisset Noriega, Angel Mendoza, Brenda L. Sánchez-Gaytán, Francisco J. Meléndez, María Eugenia Castro, Maura Cárdenas-García and Enrique González-Vergara
Pharmaceutics 2024, 16(6), 747; https://doi.org/10.3390/pharmaceutics16060747 - 31 May 2024
Viewed by 618
Abstract
Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal [...] Read more.
Citrulline (C6H13N3O3) is an amino acid found in the body as a zwitterion. This means its carboxylic and amine groups can act as Lewis donors to chelate metal cations. In addition, citrulline possesses a terminal ureido group on its aliphatic chain, which also appears to coordinate. Here, two new mixed complexes of citrulline were made with 1,10-phenanthroline and 2,2′-bipyridine. These compounds, once dissolved in water, gave aquo-complexes that were subject to DFT studies and in vitro toxicity studies on cancer cell lines (HeLa, MDA-MB-231, HCT 15, and MCF7) showed promising results. Docking studies with DNA were also conducted, indicating potential anticancer properties. Full article
(This article belongs to the Special Issue Application of Metal-Based Complexes in Cancer Treatment)
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11 pages, 772 KiB  
Article
Synthesis and Preclinical Evaluation of Radiolabeled [103Ru]BOLD-100
by Barbara Happl, Marie Brandt, Theresa Balber, Katarína Benčurová, Zeynep Talip, Alexander Voegele, Petra Heffeter, Wolfgang Kandioller, Nicholas P. Van der Meulen, Markus Mitterhauser, Marcus Hacker, Bernhard K. Keppler and Thomas L. Mindt
Pharmaceutics 2023, 15(11), 2626; https://doi.org/10.3390/pharmaceutics15112626 - 15 Nov 2023
Cited by 1 | Viewed by 1276
Abstract
The first-in-class ruthenium-based chemotherapeutic agent BOLD-100 (formerly IT-139, NKP-1339, KP1339) is currently the subject of clinical evaluation for the treatment of gastric, pancreatic, colorectal and bile duct cancer. A radiolabeled version of the compound could present a helpful diagnostic tool. Thus, this study [...] Read more.
The first-in-class ruthenium-based chemotherapeutic agent BOLD-100 (formerly IT-139, NKP-1339, KP1339) is currently the subject of clinical evaluation for the treatment of gastric, pancreatic, colorectal and bile duct cancer. A radiolabeled version of the compound could present a helpful diagnostic tool. Thus, this study investigated the pharmacokinetics of BOLD-100 in more detail to facilitate the stratification of patients for the therapy. The synthesis of [103Ru]BOLD-100, radiolabeled with carrier added (c.a.) ruthenium-103, was established and the product was characterized by HPLC and UV/Vis spectroscopy. In order to compare the radiolabeled and non-radioactive versions of BOLD-100, both complexes were fully evaluated in vitro and in vivo. The cytotoxicity of the compounds was determined in two colon carcinoma cell lines (HCT116 and CT26) and biodistribution studies were performed in Balb/c mice bearing CT26 allografts over a time period of 72 h post injection (p.i.). We report herein preclinical cytotoxicity and pharmacokinetic data for BOLD-100, which were found to be identical to those of its radiolabeled analog [103Ru]BOLD-100. Full article
(This article belongs to the Special Issue Application of Metal-Based Complexes in Cancer Treatment)
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