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Pharmaceutics
Special Issues
Research Progress of Pharmaceutical Coating Technology
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Research Progress of Pharmaceutical Coating Technology

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 2771

Special Issue Editors

Dr. Qingliang Yang

E-Mail Website
Guest Editor
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
Interests: pharmaceutical coating; pharmaceutical particles; engineered particles for drug delivery; 3D printing; mucosal drug delivery systems
Dr. Yan Yang

E-Mail Website
Guest Editor
College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, China
Interests: pharmaceutical coating; formulation development; 3D-priting; controlled drug delivery; pharmaceutical technology

Special Issue Information

Dear Colleagues,

Coating is necessary for most pharmaceutical solid dosage forms, e.g., tablets, pellets, capsules and particles. Its functionalities include enhancing drugs’ physical and chemical properties, achieving taste masking and spatiotemporally modifying drug release behaviors. Currently, liquid spray coating (organic solvent and aqueous systems) is practically utilized in the industry to obtain the coating film with acceptable uniformity. However, the presence of liquid (organic solvent and water) may cause several problems, such as solvent residue and VOC emissions. Additionally, the liquid coating process is not suitable for vulnerable actives and newly developed drug delivery systems such as micro/nanoparticles and implants. In order to fulfill the demand of these actives and delivery systems, many studies have been performed both in designing new dry coating strategies and developing novel coating materials, e.g., cell membranes with expanded functionalities. Therefore, the main aim of this Special Issue is to present current research works focusing on coating techniques for pharmaceutics, particularly dry coating and coating strategies for micro-/nano drug delivery systems. Original research articles and review papers focusing on the coating materials, mathematical simulations, process analysis technology (PAT) and coating facilities will also be welcome.

Dr. Qingliang Yang
Dr. Yan Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmaceutical coating
  • dry coating
  • powder coating
  • coating materials
  • process analysis technology
  • solventless coating
  • electrostatic coating
  • enteric coating
  • drug release
  • implant coating

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Published Papers (2 papers)

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13 pages, 4419 KiB  
Article
Assembled pH-Responsive Gastric Drug Delivery Systems Based on 3D-Printed Shells
by Haoye Bei, Pingping Zhao, Lian Shen, Qingliang Yang and Yan Yang
Pharmaceutics 2024, 16(6), 717; https://doi.org/10.3390/pharmaceutics16060717 - 27 May 2024
Viewed by 850
Abstract
Gastric acid secretion is closely associated with the development and treatment of chronic gastritis, gastric ulcers, and reflux esophagitis. However, gastric acid secretion is affected by complex physiological and pathological factors, and real-time detection and control are complicated and expensive. A gastric delivery [...] Read more.
Gastric acid secretion is closely associated with the development and treatment of chronic gastritis, gastric ulcers, and reflux esophagitis. However, gastric acid secretion is affected by complex physiological and pathological factors, and real-time detection and control are complicated and expensive. A gastric delivery system for antacids and therapeutics in response to low pH in the stomach holds promise for smart and personalized treatment of stomach diseases. In this study, pH-responsive modular units were used to assemble various modular devices for self-regulation of pH and drug delivery to the stomach. The modular unit with a release window of 50 mm2 could respond to pH and self-regulate within 10 min, which is related to its downward floatation and internal gas production. The assembled devices could stably float downward in the medium and detach sequentially at specific times. The assembled devices loaded with antacids exhibited smart pH self-regulation under complex physiological and pathological conditions. In addition, the assembled devices loaded with antacids and acid suppressors could multi-pulse or prolong drug release after rapid neutralization of gastric acid. Compared with traditional coating technology, 3D printing can print the shell layer by layer, flexibly adjust the internal and external structure and composition, and assemble it into a multi-level drug release system. Compared with traditional coating, 3D-printed shells have the advantage of the flexible adjustment of internal and external structure and composition, and are easy to assemble into a complex drug delivery system. This provides a universal and flexible strategy for the personalized treatment of diseases with abnormal gastric acid secretion, especially for delivering acid-unstable drugs. Full article
(This article belongs to the Special Issue Research Progress of Pharmaceutical Coating Technology)
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24 pages, 11453 KiB  
Article
Improving Inhalation Performance with Particle Agglomeration via Combining Mechanical Dry Coating and Ultrasonic Vibration
by Qingzhen Zhang, Zheng Wang, Kaiqi Shi, Hang Zhou, Xiaoyang Wei and Philip Hall
Pharmaceutics 2024, 16(1), 68; https://doi.org/10.3390/pharmaceutics16010068 - 31 Dec 2023
Cited by 1 | Viewed by 1420
Abstract
Agglomerate formulations for dry powder inhalation (DPI) formed with fine particles are versatile means for the highly efficient delivery of budesonide. However, uncontrolled agglomeration induces high deposition in the upper airway, causing local side effects due to high mechanical strength, worse deagglomeration, and [...] Read more.
Agglomerate formulations for dry powder inhalation (DPI) formed with fine particles are versatile means for the highly efficient delivery of budesonide. However, uncontrolled agglomeration induces high deposition in the upper airway, causing local side effects due to high mechanical strength, worse deagglomeration, and poor fine-particle delivery. In the present study, fine lactose was mechanically dry-coated prior to particle agglomeration, and the agglomerates were then spheroidized via ultrasonic vibration to improve their aerosol performance. The results showed that the agglomerate produced with the surface-enriched hydrophobic magnesium stearate and ultrasonic vibration demonstrated improved aerosolization properties, benefiting from their lower mechanical strength, less interactive cohesive force, and improved fine powder dispersion behavior. After dispersion utilizing a Turbuhaler® with a pharmaceutical cascade impactor test, a fine particle fraction (FPF) of 71.1 ± 1.3% and an artificial throat deposition of 19.3 ± 0.4% were achieved, suggesting the potential to improve the therapeutic outcomes of budesonide with less localized infections of the mouth and pharynx. Full article
(This article belongs to the Special Issue Research Progress of Pharmaceutical Coating Technology)
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