Design of Dosage Forms to Enhance Biopharmaceutical Properties
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".
Deadline for manuscript submissions: 20 December 2026 | Viewed by 682
Special Issue Editor
Interests: oral drug delivery; modified release technologies; hydrophilic matrix tablets; poorly water-soluble drugs; amorphous solid dispersions; pharmaceutical polymers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Modern drug discovery tends to produce compounds that frequently do not possess the desired physicochemical properties such as good water solubility or high permeability; consequently, they do not exhibit optimal biopharmaceutical properties. Additionally, for some investigational compounds, there may be a requirement to apply modified release technologies to optimize pharmacokinetic characteristics to provide a convenient dosing regimen and possibly to enhance tolerability. The delivery of peptides, proteins, and antibodies by routes other than parenteral infusion is an option that can offer significant convenience to patients. This Special Issue will welcome submission of manuscripts describing formulation approaches that might improve the biopharmaceutics and pharmacokinetics properties of investigational drugs or model compounds including the following:
- Prodrugs;
- Complexation (e.g. cyclodextrins);
- Nanocrystals ;
- Amorphous solid dispersions (melt extrusion or spray-dried dispersions);
- Solubilized systems such as lipid dispersion/solution formulations or self-emulsifying dispersion formulations;
- Modified-release formulations.
Manuscripts that cover novel approaches for the delivery of peptides, proteins, and antibodies by routes of administration other than parenteral infusion are also within the scope of this Special Issue. As well as oral drug delivery, compound modification or formulation approaches that can enable the effective topical delivery of drugs through the skin or in ophthalmic formulations are within the scope of the Special Issue.
Prof. Dr. Peter Timmins
Guest Editor
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Keywords
- biopharmaceutics
- drug delivery
- prodrug
- amorphous dispersion
- self-emulsifying dispersion
- cyclodextrins
- nanocrystals
- modified release
- peptide
- antibody
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