Additive Manufacturing Approaches to Produce Drug Delivery Systems, 3rd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: closed (10 March 2024) | Viewed by 2289

Special Issue Editors


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Guest Editor
Centre for Rapid and Sustainable Product Development, Polytechnic Institute of Leiria, 2430-028 Leiria, Portugal
Interests: additive manufacturing; antimicrobial materials; biomaterials; chromatography; drug delivery systems; gene therapy; tissue engineering
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Centre for Rapid and Sustainable Product Development, Polytechnic of Leiria, 2430-028 Marinha Grande, Portugal
Interests: additive manufacturing; biomimetics and bioinspiration; computer-aided engineering; computer-aided manufacturing; multi-material 3D/4D structures; industrial/biomedical applications; tissue engineering; mould design and polymer injection moulding; circular economy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, additive manufacturing approaches have provided innovative and cutting-edge technologies that have significantly improved different fields. One of the applications of these methodologies is in the production of enhanced drug delivery systems. In this regard, using these technologies enables the full manipulation of several drug delivery production parameters that are not able to be changed/combined when conventional approaches are used. Among these parameters are the porosity, layer and piece dimensions (from nanometres to the desirable measurements), interconnectivity and mono- or multi-material production. Currently, the structures produced through additive manufacturing include scaffolds used on hard tissue regeneration, wound dressings made from fibres that can perfectly mimic the soft tissue, and nanometric structures that can be used for transdermal medication. All of these kinds of structures could be filled with drugs and biochemical markers, leading to a quick and successful therapeutic process.

Topics of interest for this Special Issue include, but are not limited to, the following:

  • Medicines (oral, rectal and vaginal);
  • Intravenous and transdermal approaches;
  • Scaffolds and wound dressings;
  • Additive manufacturing technologies for drug delivery systems;
  • Drug delivery mathematical models.

Dr. Joana Valente
Prof. Dr. Nuno Alves
Guest Editors

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Keywords

  • additive manufacturing
  • drug delivery systems
  • scaffolds
  • wound dressings
  • intravenous and transdermal approaches
  • biomaterials
  • drug delivery mathematical models

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Published Papers (1 paper)

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Research

15 pages, 12240 KiB  
Article
Nanocrystalline Cellulose as a Versatile Engineering Material for Extrusion-Based Bioprinting
by Sophia A. Read, Chee Shuen Go, Miguel J. S. Ferreira, Cosimo Ligorio, Susan J. Kimber, Ahu G. Dumanli and Marco A. N. Domingos
Pharmaceutics 2023, 15(10), 2432; https://doi.org/10.3390/pharmaceutics15102432 - 7 Oct 2023
Cited by 3 | Viewed by 1923
Abstract
Naturally derived polysaccharide-based hydrogels, such as alginate, are frequently used in the design of bioinks for 3D bioprinting. Traditionally, the formulation of such bioinks requires the use of pre-reticulated materials with low viscosities, which favour cell viability but can negatively influence the resolution [...] Read more.
Naturally derived polysaccharide-based hydrogels, such as alginate, are frequently used in the design of bioinks for 3D bioprinting. Traditionally, the formulation of such bioinks requires the use of pre-reticulated materials with low viscosities, which favour cell viability but can negatively influence the resolution and shape fidelity of the printed constructs. In this work, we propose the use of cellulose nanocrystals (CNCs) as a rheological modifier to improve the printability of alginate-based bioinks whilst ensuring a high viability of encapsulated cells. Through rheological analysis, we demonstrate that the addition of CNCs (1% and 2% (w/v)) to alginate hydrogels (1% (w/v)) improves shear-thinning behaviour and mechanical stability, resulting in the high-fidelity printing of constructs with superior resolution. Importantly, LIVE/DEAD results confirm that the presence of CNCs does not seem to affect the health of immortalised chondrocytes (TC28a2) that remain viable over a period of seven days post-encapsulation. Taken together, our results indicate a favourable effect of the CNCs on the rheological and biocompatibility properties of alginate hydrogels, opening up new perspectives for the application of CNCs in the formulation of bioinks for extrusion-based bioprinting. Full article
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