Prospects of the Prodrug Approach: From Initial Design to Clinical Application
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: closed (31 October 2021) | Viewed by 10392
Special Issue Editors
Interests: biopharmaceutics; modified release; dissolution; infection prevention; biopolymers
Special Issues, Collections and Topics in MDPI journals
Interests: prodrugs; drug delivery; drug targeting; oral drug absorption; biopharmaceutics; intestinal permeability; neuropharmacology; Parkinson’s disease; inflammatory bowel disease
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Prodrugs are an increasingly used tool for overcoming physicochemical, biopharmaceutical, pharmacokinetic, and pharmacodynamic obstacles of pharmacologically active agents. To date, it is estimated that 10% of drugs in the market are classified as prodrugs; among low-molecular-weight drugs, one third are categorized as prodrugs. The increased utilization of prodrug strategies in drug development results from an increased understanding of the biological mechanisms, enabling the smart design of prodrugs with better biopharmaceutical and safety profiles. Even though smart prodrug design is challenging, it can be faster, more practical, and more efficacious than other formulation approaches and is certainly preferable in most cases to going back to the drawing board to search for an entirely new compound. When considered at the early stages of preclinical development, the prodrug approach may save time, protect resources, and facilitate the overall drug development process. This Special Issue serves to present and highlight the most recent examples and future uses of the prodrug approach from its initial design to the clinical setting.
Prof. Dr. Barbara R. Conway
Dr. Milica Markovic
Guest Editors
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Keywords
- prodrugs
- prodrug design
- bioconversion
- enzyme-mediated prodrug activation
- drug targeting
- drug delivery
- clinical prodrug use
- oral bioavailability
- ProTide