Population Pharmacokinetics: Where Are We Now?

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".

Deadline for manuscript submissions: 28 February 2026 | Viewed by 349

Special Issue Editors


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Guest Editor
College of Pharmacy, Wonkwang University, Iksan 54538, Republic of Korea
Interests: clinical pharmacokinetics (PK) and pharmacodynamics (PD); population PK/PD modeling and simulation; physiologically-based pharmacokinetic (PBPK) modeling and simulation; individualized pharmacotherapy; early phase clinical trial

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Guest Editor
Department of Bioengineering and Therapeutic Sciences, University of California, San Fransisco, CA, USA
Interests: pharmacometrics; clinical pharmacology; PK/PD modeling; translational modeling; model-informed dose optimization

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to our upcoming Special Issue, “Population Pharmacokinetics: Where Are We Now?”.

Population pharmacokinetics has become increasingly integrated across drug development, regulatory decision-making, and patient care. Its role in addressing knowledge gaps in both preclinical and clinical settings and thereby advancing global health continues to grow. Population pharmacokinetics provides robust quantitative foundations for dose selection and optimization, clinical trial design, and personalized therapy. This Special Issue aims to showcase recent methodological advances and innovative, impactful applications that reflect the current state and future direction of the field.

We welcome submissions aligned with, but not limited to, the following themes:

  1. Methodological advances

- Incorporation of machine learning into conventional population pharmacokinetic approaches.

- Innovative and automated approaches for covariate identification and model building.

  1. Model-informed drug development

- Translational pharmacokinetic/pharmacodynamic modeling to efficiently bridge preclinical findings to optimal human dose selection and clinical trial design.

- Population pharmacokinetics and exposure–response modeling to identify sources of variability and support rationale-driven development decisions.

  1. Model-informed advancements in current treatment strategies

- Population pharmacokinetics focused on special populations, such as pediatrics and pregnancy, to advance understanding and improve dosing strategies.

- Real-world data-based population pharmacokinetics in patient populations to enhance clinical practice.

We look forward to receiving your valuable contributions that advance the science and clinical applications of population pharmacokinetics.

Dr. Su-jin Rhee
Dr. Eunsol Yang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacometrics
  • population pharmacokinetics
  • pharmacokinetics/pharmacodynamics
  • machine learning
  • model-informed drug development
  • model-informed dose optimization
  • special populations
  • real-world data
  • personalized therapy

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Published Papers

This special issue is now open for submission.
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