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Pharmaceutics
Special Issues
Microneedle-Enhanced Dermal Delivery
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Microneedle-Enhanced Dermal Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 2817

Special Issue Editor

Prof. Dr. Audra Stinchcomb

E-Mail Website
Guest Editor
Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland, Baltimore, MD 21201, USA
Interests: transdermal drug delivery; oromucosal drug delivery; transdermal prodrugs; microneedle-enhanced delivery; translational research models for public-private partnerships; regulatory science

Special Issue Information

Dear Colleagues,

Microneedle-enhanced dermal delivery is a rapidly growing and exciting area of pharmaceutical research. Significant improvements in vaccines and certain therapeutic subcategories are on the horizon, and it is important to keep abreast of these novel microneedle technologies. We invite articles on all aspects of microneedle-enhanced dermal delivery for this Special Issue. Special consideration will be given to research articles that address the translational aspects of these evolving products. Translational aspects include, but are not limited to, scalability, sterilization, adverse reactions, relevant in vitro and in vivo testing models, and all types of studies in humans. We look forward to your innovative and thoughtful manuscripts.

Prof. Dr. Audra Stinchcomb
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • microneedle
  • intradermal
  • therapeutics
  • vaccines
  • toxicology
  • immunology
  • systemic delivery
  • local delivery
  • bioengineering

Published Papers (1 paper)

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Research

13 pages, 3200 KiB  
Article
Effective Dispensing Methods for Loading Drugs Only to the Tip of DNA Microneedles
by Moonjeong Bok, Zhi-Jun Zhao, Soon Hyoung Hwang, Hyeok-Joong Kang, Sohee Jeon, Jiwoo Ko, Jiwon Jeong, Young Seok Song, Eunju Lim and Jun-Ho Jeong
Pharmaceutics 2020, 12(10), 954; https://doi.org/10.3390/pharmaceutics12100954 - 10 Oct 2020
Cited by 6 | Viewed by 2538
Abstract
Here, we propose a novel and simple method to efficiently capture the diffusion of fluorescein isothiocyanate (FITC)-dextran from a biocompatible substance and load the drug only to the tip of DNA microneedles. A dispensing and suction method was chosen to fabricate the designed [...] Read more.
Here, we propose a novel and simple method to efficiently capture the diffusion of fluorescein isothiocyanate (FITC)-dextran from a biocompatible substance and load the drug only to the tip of DNA microneedles. A dispensing and suction method was chosen to fabricate the designed microneedles with efficient amounts of FITC as the drug model. Importantly, the vacuum process, which could influence the capturing of FITC diffusion from the tip, was evaluated during the manufacturing process. In addition, the simulations were consistent with the experimental results and showed apparent diffusion. Moreover, dextrans of different molecular weights labeled with FITC were chosen to fabricate the tip of microneedles for demonstrating their applicability. Finally, a micro-jetting system with a micro-nozzle (diameter: 80 μm) was developed to achieve the accurate and rapid loading of small amounts of FITC using the anti-diffusion and micro-jetting methods. Our method not only uses a simple and fast manufacturing process, but also fabricates the tips of microneedles more efficiently with FITC compared with the existing methods. We believe that the proposed method is essential for the clinical applications of the microneedle drug delivery platform. Full article
(This article belongs to the Special Issue Microneedle-Enhanced Dermal Delivery)
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