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Pharmaceutics
Special Issues
Recent Trends in Dermal Smart Delivery Systems
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Recent Trends in Dermal Smart Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 February 2022) | Viewed by 3059

Special Issue Editors

Dr. Magdalena Martinka Maksymiak

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Guest Editor
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Skłodowska St., 41-800 Zabrze, Poland
Interests: cosmetic delivery system; biodegradable polymers; polyhydroxyalkanoates; anionic ring-opening polymerization; antioxidants; polymer mass spectrometry
Dr. Wioleta Borzęcka

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Guest Editor
Centre of Polymer and Carbon Materials, Polish Academy of Sciences, 34. M. C. Skłodowska St., 41-800 Zabrze, Poland
Interests: smart delivery systems; polymeric nanoparticles; silica nanoparticles; iron oxide nanoparticles; photosensitizers; photodynamic therapy
Prof. Dr. Begoña Delgado-Charro

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Guest Editor
Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, UK
Interests: transdermal and topical drug delivery; formulation; chemical and iontophoretic permeation enhancement; topical bioequivalence; nail drug delivery; non-invasive sampling; prediction of skin absorption
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently, nano-based smart delivery systems have allowed for the development of novel carriers for the efficient transport and controlled release of active molecules in a wide range of applications, such as biotechnology, medicine and cosmetology.

In particular, the use of functional nanoplatforms in dermal delivery systems has contributed to the improvement of the skin penetration capabilities of various loaded agents (e.g., antioxidants, drugs, dyes, photosensitizers) by increasing the duration of their activity via slow release and specific targeting.

Moreover, these smart platforms offer the possibility to overcome the challenges relating to the permeation and skin irritation of conventional compounds used in skin treatments.

This Special Issue aims to cover different aspects of the development of smart delivery systems in the field of dermal delivery. Authors are invited to submit original research articles and reviews in this important and exciting research field.

Dr. Magdalena Martinka Maksymiak
Dr. Wioleta Borzęcka
Prof. Dr. Begoña Delgado-Charro
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • novel dermal delivery systems
  • designing of smart delivery systems
  • biocompatible and biodegradable polymer systems
  • bioactive oligomers and polymers
  • targeted dermal delivery systems

Published Papers (1 paper)

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Research

16 pages, 2230 KiB  
Article
Influence of Stabilizer on the Development of Luteolin Nanosuspension for Cutaneous Delivery: An In Vitro and In Vivo Evaluation
by Mohammed Elmowafy, Khaled Shalaby, Mohammad M. Al-Sanea, Omnia M. Hendawy, Ayman Salama, Mohamed F. Ibrahim and Mohammed M. Ghoneim
Pharmaceutics 2021, 13(11), 1812; https://doi.org/10.3390/pharmaceutics13111812 - 30 Oct 2021
Cited by 17 | Viewed by 2361
Abstract
Luteolin is a natural drug used as an antioxidant and anti-inflammatory, but unfortunately, it possesses low water solubility, which hinders its delivery via the skin. The main objective of this study was to prepare a luteolin-loaded nanosuspension by the antisolvent precipitation/sonication technique and [...] Read more.
Luteolin is a natural drug used as an antioxidant and anti-inflammatory, but unfortunately, it possesses low water solubility, which hinders its delivery via the skin. The main objective of this study was to prepare a luteolin-loaded nanosuspension by the antisolvent precipitation/sonication technique and study the effects of four stabilizers (two nonionic stabilizers, Pluronic F127 and Tween 80, and two polymeric stabilizers, HPMC and alginate) on the physicochemical properties of the prepared formulations. The selected formulations were incorporated into a gel base to evaluate their skin permeability and anti-inflammatory efficacy. The particle size was in the nanosize range (in the range from 468.1 ± 18.6 nm to 1024.8 ± 15.9 nm), while the zeta potential was negative and in the range from −41.7 ± 6.3 mV to −15.3 ± 1.9 mV. In particular, alginate-stabilized nanosuspensions showed the smallest particle size, the highest zeta potential value, and excellent stability due to the dual stabilizing effects (electrostatic and steric effects). The DSC results revealed a less crystalline structure of luteolin in lyophilized NS2 and NS12. Formulations stabilized by 1% Pluronic (NS2) and 2% alginate (NS12) were incorporated into a carbopol 940 gel base and showed good organoleptic character (homogenous with no evidenced phase separation or grittiness). In vitro dissolution studies showed that NS12 enhanced luteolin release rates, indicating the effect of particle size on the drug release pattern. On the other hand, NS2 showed enhanced skin permeability and anti-inflammatory effect in a carrageenan-induced paw edema model, revealing the surface activity role of the stabilizers. In conclusion, while alginate increased the nanosuspension stability by means of dual stabilizing effects, Pluronic F127 improved the skin delivery and pharmacodynamic efficacy of luteolin. Full article
(This article belongs to the Special Issue Recent Trends in Dermal Smart Delivery Systems)
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