Non-invasive Drug, Protein and Gene Delivery Systems: Current Progress and Future Prospects

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (28 February 2021) | Viewed by 5244

Special Issue Editor


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Guest Editor
School of Pharmacy, University of Waterloo, 10 Victoria St S., Kitchener, ON N2G 1C5, Canada
Interests: pharmaceutical nanotechnology; non-invasive drug; protein and gene delivery system design

Special Issue Information

Dear Colleagues,

It is with great delight and honor to invite you to contribute to the upcoming Special Issue of Pharmaceutics on “Non-invasive Drug, Protein and Gene Delivery Systems: Current Progress and Future Prospects”.

This issue will be a collection of frontier research papers focusing on exploring the newest knowledge, research and translation in non-invasive approaches related to

  • pharmaceutical, chemical, physicochemical and biophysical non-invasive technologies for improved therapies, diagnostics and imaging in all clinical areas of application
  • needle-free administration methods using novel dosage forms, nanotechnology and devices
  • research on dermal, transdermal, pulmonary, ocular, otic, vaginal, rectal, buccal and oral administration methods and potential solutions to the challenges of the barriers in these routes of administration
  • non-invasive delivery systems for small molecules, proteins, peptides, DNA, RNA and vaccines
  • critical appraisals and comparisons of benefits and reliability of non-invasive technologies, including modelling and simulation approaches
  • evaluation of patient benefits of non-invasive technologies in hospital and home settings

The deadline for contribution of either a research paper or a review article to this Special Issue will be by 31 October 2020.

At this time, if you are interested, please send me the tentative title of the article and a short outline of the scope of the paper, and any questions you may have.

I hope that you will accept the invitation to be part of this exciting Special Issue.

Prof. Marianna Foldvari
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • non-invasive drug delivery
  • needle-free
  • pharmaceutical
  • small molecule drugs
  • proteins and peptides
  • nucleic acids
  • vaccines
  • nanomedicine
  • dosage forms
  • devices

Published Papers (1 paper)

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Review

25 pages, 2716 KiB  
Review
Flow and Particle Modelling of Dry Powder Inhalers: Methodologies, Recent Development and Emerging Applications
by Zhanying Zheng, Sharon Shui Yee Leung and Raghvendra Gupta
Pharmaceutics 2021, 13(2), 189; https://doi.org/10.3390/pharmaceutics13020189 - 1 Feb 2021
Cited by 22 | Viewed by 4938
Abstract
Dry powder inhaler (DPI) is a device used to deliver a drug in dry powder form to the lungs. A wide range of DPI products is currently available, with the choice of DPI device largely depending on the dose, dosing frequency and powder [...] Read more.
Dry powder inhaler (DPI) is a device used to deliver a drug in dry powder form to the lungs. A wide range of DPI products is currently available, with the choice of DPI device largely depending on the dose, dosing frequency and powder properties of formulations. Computational fluid dynamics (CFD), together with various particle motion modelling tools, such as discrete particle methods (DPM) and discrete element methods (DEM), have been increasingly used to optimise DPI design by revealing the details of flow patterns, particle trajectories, de-agglomerations and depositions within the device and the delivery paths. This review article focuses on the development of the modelling methodologies of flow and particle behaviours in DPI devices and their applications to device design in several emerging fields. Various modelling methods, including the most recent multi-scale approaches, are covered and the latest simulation studies of different devices are summarised and critically assessed. The potential and effectiveness of the modelling tools in optimising designs of emerging DPI devices are specifically discussed, such as those with the features of high-dose, pediatric patient compatibility and independency of patients’ inhalation manoeuvres. Lastly, we summarise the challenges that remain to be addressed in DPI-related fluid and particle modelling and provide our thoughts on future research direction in this field. Full article
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