Layered Double Hydroxide Used in Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923).

Deadline for manuscript submissions: closed (19 December 2014) | Viewed by 41966

Special Issue Editors

Chemistry Research Laboratory, Department of Chemistry, University of Oxford, Oxford OX13TA, UK
Interests: layered double hydroxides; intercalation; in-situ diffraction; materials; organometallic; catalysis
UCL School of Pharmacy, University College London, 29 - 39 Brunswick Square, London WC1N 1AX, UK
Interests: drug delivery; vaccines; nanomaterials; formulation science
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Special Issue Information

Dear Colleague,

The anion exchange capability of layered double hydroxides (LDHs), coupled with the ability of many active pharmaceutical ingredients (APIs) to form anions, has resulted in an explosion of interest in using LDHs for drug delivery applications. A search in Google Scholar for “layered double hydroxides AND drug delivery” results in some 21,500 hits, clearly demonstrating the research effort underway in this area. The Special Issue of Pharmaceutics on “Layered double hydroxides in drug delivery” will address all areas of pharmaceutics where LDHs have been explored, from their use as controlled or targeted release formulations (either alone or in combination with other excipients) through to their applications in DNA or RNA delivery on the sub-cellular level. Original research papers or review articles on any of these aspects are welcomed for this Special Issue.

Prof. Dr. Dermot O’Hare
Dr. Gareth R. Williams
Guest Editors

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Keywords

  • layered double hydroxide
  • drug delivery
  • gene delivery
  • controlled release
  • targeted release
  • sustained release

Published Papers (4 papers)

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Research

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3331 KiB  
Article
Enhanced Cellular Delivery and Biocompatibility of a Small Layered Double Hydroxide–Liposome Composite System
by Haiyan Dong, Harendra S. Parekh and Zhi Ping Xu
Pharmaceutics 2014, 6(4), 584-598; https://doi.org/10.3390/pharmaceutics6040584 - 26 Nov 2014
Cited by 15 | Viewed by 6750
Abstract
The various classes of gene delivery vectors possess distinct advantages and disadvantages, each of which impacts on cargo loading, delivery and, ultimately, its function. With this in mind, herein we report on a small layered double hydroxide (sLDH)–liposome composite system, drawing upon the [...] Read more.
The various classes of gene delivery vectors possess distinct advantages and disadvantages, each of which impacts on cargo loading, delivery and, ultimately, its function. With this in mind, herein we report on a small layered double hydroxide (sLDH)–liposome composite system, drawing upon the salient features of LDH and liposome classes of vectors, while avoiding their inherent shortfalls when used independently. sLDH–liposome composites were prepared by the hydration of freeze-dried matrix method. These composite systems, with a Z-average size of ≈200 nm, exhibited low cytotoxicity and demonstrated good suspension stability, both in water and cell culture medium after rehydration. Our studies demonstrate that short dsDNAs/ssDNAs were completely bound and protected in the composite system at an sLDH:DNA mass ratio of 20:1, regardless of the approach to DNA loading. This composite system delivered DNA to HCT-116 cells with ≈3-fold greater efficiency, when compared to sLDH alone. Our findings point towards the sLDH-liposome composite system being an effective and biocompatible gene delivery system. Full article
(This article belongs to the Special Issue Layered Double Hydroxide Used in Drug Delivery)
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2136 KiB  
Article
Mixing Acid Salts and Layered Double Hydroxides in Nanoscale under Solid Condition
by Hirokazu Nakayama and Aki Hayashi
Pharmaceutics 2014, 6(3), 436-446; https://doi.org/10.3390/pharmaceutics6030436 - 30 Jul 2014
Cited by 7 | Viewed by 6384
Abstract
The immobilization of potassium sorbate, potassium aspartate and sorbic acid in layered double hydroxide under solid condition was examined. By simply mixing two solids, immobilization of sorbate and aspartate in the interlayer space of nitrate-type layered double hydroxide, so called intercalation reaction, was [...] Read more.
The immobilization of potassium sorbate, potassium aspartate and sorbic acid in layered double hydroxide under solid condition was examined. By simply mixing two solids, immobilization of sorbate and aspartate in the interlayer space of nitrate-type layered double hydroxide, so called intercalation reaction, was achieved, and the uptakes, that is, the amount of immobilized salts and the interlayer distances of intercalation compounds were almost the same as those obtained in aqueous solution. However, no intercalation was achieved for sorbic acid. Although intercalation of sorbate and aspartate into chloride-type layered double hydroxide was possible, the uptakes for these intercalation compounds were lower than those obtained using nitrate-type layered double hydroxide. The intercalation under solid condition could be achieved to the same extent as for ion-exchange reaction in aqueous solution, and the reactivity was similar to that observed in aqueous solution. This method will enable the encapsulation of acidic drug in layered double hydroxide as nano level simply by mixing both solids. Full article
(This article belongs to the Special Issue Layered Double Hydroxide Used in Drug Delivery)
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926 KiB  
Article
Influence of Hydrothermal Treatment on Physicochemical Properties and Drug Release of Anti-Inflammatory Drugs of Intercalated Layered Double Hydroxide Nanoparticles
by Zi Gu, Aihua Wu, Li Li and Zhi Ping Xu
Pharmaceutics 2014, 6(2), 235-248; https://doi.org/10.3390/pharmaceutics6020235 - 22 May 2014
Cited by 28 | Viewed by 7935
Abstract
The synthesis method of layered double hydroxides (LDHs) determines nanoparticles’ performance in biomedical applications. In this study, hydrothermal treatment as an important synthesis technique has been examined for its influence on the physicochemical properties and the drug release rate from drug-containing LDHs. We [...] Read more.
The synthesis method of layered double hydroxides (LDHs) determines nanoparticles’ performance in biomedical applications. In this study, hydrothermal treatment as an important synthesis technique has been examined for its influence on the physicochemical properties and the drug release rate from drug-containing LDHs. We synthesised MgAl–LDHs intercalated with non-steroidal anti-inflammatory drugs (i.e., naproxen, diclofenac and ibuprofen) using a co-precipitation method with or without hydrothermal treatment (150 °C, 4 h). After being hydrothermally treated, LDH–drug crystallites increased in particle size and crystallinity, but did not change in the interlayer anion orientation, gallery height and chemical composition. The drug release patterns of all studied LDH–drug hybrids were biphasic and sustained. LDHs loaded with diclofenac had a quicker drug release rate compared with those with naproxen and ibuprofen, and the drug release from the hydrothermally-treated LDH–drug was slower than the freshly precipitated LDH–drug. These results suggest that the drug release of LDH–drugs is influenced by the crystallite size of LDHs, which can be controlled by hydrothermal treatment, as well as by the drug molecular physicochemical properties. Full article
(This article belongs to the Special Issue Layered Double Hydroxide Used in Drug Delivery)
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Review

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2325 KiB  
Review
Layered Double Hydroxide-Based Nanocarriers for Drug Delivery
by Xue Bi, Hui Zhang and Liguang Dou
Pharmaceutics 2014, 6(2), 298-332; https://doi.org/10.3390/pharmaceutics6020298 - 17 Jun 2014
Cited by 170 | Viewed by 19768
Abstract
Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize [...] Read more.
Biocompatible clay materials have attracted particular attention as the efficient drug delivery systems (DDS). In this article, we review developments in the use of layered double hydroxides (LDHs) for controlled drug release and delivery. We show how advances in the ability to synthesize intercalated structures have a significant influence on the development of new applications of these materials. We also show how modification and/or functionalization can lead to new biotechnological and biomedical applications. This review highlights the most recent progresses in research on LDH-based controlled drug delivery systems, focusing mainly on: (i) DDS with cardiovascular drugs as guests; (ii) DDS with anti-inflammatory drugs as guests; and (iii) DDS with anti-cancer drugs as guests. Finally, future prospects for LDH-based drug carriers are also discussed. Full article
(This article belongs to the Special Issue Layered Double Hydroxide Used in Drug Delivery)
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