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Pharmaceutics
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Organic-Inorganic Nanocomposites as Delivery Systems of Therapeutic Agents for Regenerative...
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Organic-Inorganic Nanocomposites as Delivery Systems of Therapeutic Agents for Regenerative Medicine

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 14825

Special Issue Editors

Dr. Kai Zheng

E-Mail Website
Guest Editor
Engineering Research Center of Stomatological Translational Medicine, Nanjing Medical University, Nanjing 210029, China
Interests: bioactive glasses; composite hydrogels; coating; nanoparticles; tissue regeneration; additive manufacturing
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Annabel Braem

E-Mail Website
Guest Editor
Department of Materials Engineering (MTM), Biomaterials and Tissue Engineering Research Group, KU Leuven, 3000 Leuven, Belgium
Interests: biomaterials; bioceramics; surface functionalization; electrophoretic deposition; additive manufacturing; antimicrobial materials; dental implants

Special Issue Information

Dear Colleagues,

Organic–inorganic nanocomposites are attracting increasing attention for regenerative medicine. These materials combine the properties of both the organic phase (natural polymers, proteins, etc.) and inorganic phase (bioactive glasses, bioceramics, silica nanoparticles, etc.), and consequently exhibit a unique set of physical, chemical, mechanical and biological properties that are otherwise not found in a single constituent material. Additionally, organic–inorganic nanocomposites can act as multifunctional smart delivery platforms of therapeutic agents (including drugs and biologically active ions). As such, these nanocomposite materials can combine the benefits of different nanoscale structural components to synergize the outcome of therapeutic delivery for hard and soft tissue regenerative applications. Novel applications of organic–inorganic nanocomposites are fast emerging, and applications, such as drug-releasing bioink for biofabrication of 3D structures ready for implantation or as stimuli-responsive theranostic nanoplatforms for tissue regeneration and disease diagnosis/treatment, have been suggested. 

The aim of this Special Issue is to cover the cutting-edge research activities and recent research advancements in the area of organic–inorganic nanocomposites that enable smart delivery of therapeutic agents for regenerative medicine. We invite articles on all aspects related to this topic. Types of manuscripts to be featured mainly include Original Research and Perspective articles. Review articles that describe the current state of the art in organic–inorganic nanocomposites for specific tissue-regenerative applications (e.g., bone repair, wound healing, infection prevention) are welcome.

Prof. Dr. Kai Zheng
Prof. Dr. Annabel Braem
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bone tissue engineering
  • soft tissue regeneration
  • infection prevention
  • drug delivery
  • nanocomposite hydrogels
  • nanocomposite bioink
  • theranostic nanoplatforms
  • coatings
  • stimuli-responsive controlled release
  • smart biomaterials

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Published Papers (4 papers)

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Research

22 pages, 7556 KiB  
Article
Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites
by Arooj Munir, Danijela Marovic, Liebert Parreiras Nogueira, Roger Simm, Ali-Oddin Naemi, Sander Marius Landrø, Magnus Helgerud, Kai Zheng, Matej Par, Tobias T. Tauböck, Thomas Attin, Zrinka Tarle, Aldo R. Boccaccini and Håvard J. Haugen
Pharmaceutics 2022, 14(10), 2241; https://doi.org/10.3390/pharmaceutics14102241 - 20 Oct 2022
Cited by 8 | Viewed by 4582
Abstract
Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the [...] Read more.
Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant. Surface micromorphology and elemental analysis were performed to evaluate the homogeneous distribution of filler particles. The study investigated the effects of Cu-MBGN on the degree of conversion, polymerization shrinkage, porosity, ion release and anti-bacterial activity on S. mutans and A. naeslundii. Experimental materials containing Cu-MBGN showed a dose-dependent Cu release with an initial burst and a further increase after 28 days. The composite containing 10% Cu-MBGN had the best anti-bacterial effect on S. mutans, as evidenced by the lowest adherence of free-floating bacteria and biofilm formation. In contrast, the 45S5-containing materials had the highest S. mutans adherence. Ca release was highest in the bioactive control containing 15% 45S5, which correlated with the highest number of open porosities on the surface. Polymerization shrinkage was similar for all tested materials, ranging from 3.8 to 4.2%, while the degree of conversion was lower for Cu-MBGN materials. Cu-MBGN composites showed better anti-bacterial properties than composites with 45S5 BG. Full article
(This article belongs to the Special Issue Organic-Inorganic Nanocomposites as Delivery Systems of Therapeutic Agents for Regenerative Medicine)
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15 pages, 3483 KiB  
Article
Boswellia sacra Extract-Loaded Mesoporous Bioactive Glass Nano Particles: Synthesis and Biological Effects
by Kanwal Ilyas, Lamia Singer, Muhammad Asim Akhtar, Christoph P. Bourauel and Aldo R. Boccaccini
Pharmaceutics 2022, 14(1), 126; https://doi.org/10.3390/pharmaceutics14010126 - 5 Jan 2022
Cited by 11 | Viewed by 2739
Abstract
Bioactive glasses (BGs) are being increasingly considered for numerous biomedical applications. The loading of natural compounds onto BGs to increase the BG biological activity is receiving increasing attention. However, achieving efficient loading of phytotherapeutic compounds onto the surface of bioactive glass is challenging. [...] Read more.
Bioactive glasses (BGs) are being increasingly considered for numerous biomedical applications. The loading of natural compounds onto BGs to increase the BG biological activity is receiving increasing attention. However, achieving efficient loading of phytotherapeutic compounds onto the surface of bioactive glass is challenging. The present work aimed to prepare novel amino-functionalized mesoporous bioactive glass nanoparticles (MBGNs) loaded with the phytotherapeutic agent Boswellia sacra extract. The prepared amino-functionalized MBGNs showed suitable loading capacity and releasing time. MBGNs (nominal composition: 58 wt% SiO2, 37 wt% CaO, 5 wt% P2O5) were prepared by sol-gel-modified co-precipitation method and were successfully surface-modified by using 3-aminopropyltriethoxysilane (APTES). In order to evaluate MBGNs loaded with Boswellia sacra, morphological analysis, biological studies, physico-chemical and release studies were performed. The successful functionalization and loading of the natural compound were confirmed with FTIR, zeta-potential measurements and UV-Vis spectroscopy, respectively. Structural and morphological evaluation of MBGNs was done by XRD, SEM and BET analyses, whereas the chemical analysis of the plant extract was done using GC/MS technique. The functionalized MBGNs showed high loading capacity as compared to non-functionalized MBGNs. The release studies revealed that Boswellia sacra molecules were released via controlled diffusion and led to antibacterial effects against S. aureus (Gram-positive) bacteria. Results of cell culture studies using human osteoblastic-like cells (MG-63) indicated better cell viability of the Boswellia sacra-loaded MBGNs as compared to the unloaded MBGNs. Therefore, the strategy of combining the properties of MBGNs with the therapeutic effects of Boswellia sacra represents a novel, convenient step towards the development of phytotherapeutic-loaded antibacterial, inorganic materials to improve tissue healing and regeneration. Full article
(This article belongs to the Special Issue Organic-Inorganic Nanocomposites as Delivery Systems of Therapeutic Agents for Regenerative Medicine)
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16 pages, 3985 KiB  
Article
3D GelMA ICC Scaffolds Combined with SW033291 for Bone Regeneration by Modulating Macrophage Polarization
by Qian Jiang, Guo Bai, Xin Liu, Yuxiao Chen, Guangzhou Xu, Chi Yang and Zhiyuan Zhang
Pharmaceutics 2021, 13(11), 1934; https://doi.org/10.3390/pharmaceutics13111934 - 16 Nov 2021
Cited by 8 | Viewed by 3118
Abstract
Despite the interaction between bone marrow mesenchymal stem cells (BMSCs) and macrophages has been found to play a critical role in repairing bone defects, it remains a challenge to develop a desirable tissue engineering scaffold for synchronous regulation of osteogenic differentiation and macrophage [...] Read more.
Despite the interaction between bone marrow mesenchymal stem cells (BMSCs) and macrophages has been found to play a critical role in repairing bone defects, it remains a challenge to develop a desirable tissue engineering scaffold for synchronous regulation of osteogenic differentiation and macrophage polarization. Herein, this study proposed a novel strategy to treat bone defects based on three-dimensional Gelatin Methacryloyl Inverted Colloidal Crystal (3D GelMA ICC) scaffold and an active 15-hydroxyprostaglandin dehydrogenase (15-PGDH) inhibitor SW033291. Specifically, the 3D GelMA ICC scaffolds were firstly prepared by colloidal templating method, which displayed good cell attachment and promoted intercellular interaction among macrophage and BMSCs due to its uniform pore interconnectivity. By combined use of SW033291, the release of Prostaglandin E2 (PGE2) from BMSCs on the GelMA ICC scaffold was significantly upregulated and macrophages M2 polarization was markedly increased. In turn, BMSCs proliferation and osteogenic differentiation was further enhanced by paracrine regulation of M2 macrophage, and thus finally caused more in vivo new bone formation by shaping up a pro-regenerative local immune microenvironment surrounding GelMA ICC scaffold. Our findings demonstrate the potential of 3D GelMA ICC scaffolds combined with SW033291 to become an effective tissue engineering strategy for bone regeneration. Full article
(This article belongs to the Special Issue Organic-Inorganic Nanocomposites as Delivery Systems of Therapeutic Agents for Regenerative Medicine)
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15 pages, 4152 KiB  
Article
Mg-BGNs/DCECM Composite Scaffold for Cartilage Regeneration: A Preliminary In Vitro Study
by Zhiguo Yuan, Zhuocheng Lyu, Xin Liu, Jue Zhang and You Wang
Pharmaceutics 2021, 13(10), 1550; https://doi.org/10.3390/pharmaceutics13101550 - 24 Sep 2021
Cited by 11 | Viewed by 2461
Abstract
Cartilage lesions can lead to progressive cartilage degeneration; moreover, they involve the subchondral bone, resulting in osteoarthritis (OA) onset and progression. Bioactive glasses, with the dual function of supporting both bone and cartilage regeneration, have become a promising biomaterial for cartilage/bone engineering applications. [...] Read more.
Cartilage lesions can lead to progressive cartilage degeneration; moreover, they involve the subchondral bone, resulting in osteoarthritis (OA) onset and progression. Bioactive glasses, with the dual function of supporting both bone and cartilage regeneration, have become a promising biomaterial for cartilage/bone engineering applications. This is especially true for those containing therapeutic ions, which act as ion delivery systems and may further promote cartilage repair. In this study, we successfully fabricated Mg-containing bioactive glass nanospheres (Mg-BGNs) and constructed three different scaffolds, DCECM, Mg-BGNs-1/DCECM (1% Mg-BGNs), and Mg-BGNs-2/DCECM (10% Mg-BGNs) scaffold, by incorporating Mg-BGNs into decellularized cartilage extracellular matrix (DCECM). All three scaffolds showed favorable microarchitectural and ion controlled-release properties within the ideal range of pore size for tissue engineering applications. Furthermore, all scaffolds showed excellent biocompatibility and no signs of toxicity. Most importantly, the addition of Mg-BGNs to the DCECM scaffolds significantly promoted cell proliferation and enhanced chondrogenic differentiation induction of mesenchymal stem cells (MSCs) in pellet culture in a dose-dependent manner. Collectively, the multifunctional Mg-BGNs/DCECM composite scaffold not only demonstrated biocompatibility but also a significant chondrogenic response. Our study suggests that the Mg-BGNs/DCECM composite scaffold would be a promising tissue engineering tool for osteochondral lesions, with the ability to simultaneously stimulate articular cartilage and subchondral bone regeneration. Full article
(This article belongs to the Special Issue Organic-Inorganic Nanocomposites as Delivery Systems of Therapeutic Agents for Regenerative Medicine)
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