Peptide‐Mediated Targeted Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".

Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 2367

Special Issue Editor


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Guest Editor
Department of Experimental and Clinical Pharmacology, University of Minnesota, Minneapolis, MN 55455, USA
Interests: in vivo phage display; peptide-based delivery

Special Issue Information

Dear Colleagues,

Peptides are attractive carriers of diagnostic and therapeutic agents, and can improve the specificity and efficiency of their delivery into a given pathological tissue or cell. This property is largely attributed to selective binding to their receptor proteins, which may be biomarkers for the tissue or cells of interest. Peptide–receptor ligation can invoke downstream signaling cascades and/or trigger cellular transport processes for cargo intake and even exchange between cells. Phage display has been useful in discovering such peptide tools in a high-throughput manner, which may also lead to the identification of novel biomarkers for target protein/cell/tissue. Understanding how peptides function as therapeutics themselves or as delivery vehicles, and exploring new screening strategies, will shed light on cell biology and physiology, in addition to providing better ways to develop peptide-based delivery and therapeutic technologies. 

This Special Issue highlights recent findings from top experts around the world on peptide-guided drug delivery and therapeutics development. Original research articles and reviews in the Issue will provide insights into peptide and biomarker discovery, cellular responses to peptide–receptor interactions, as well as preclinical and clinical applications of peptides in navigating molecular and nanoscale diagnostic and therapeutic payloads.

Dr. Hongbo Pang
Guest Editor

Manuscript Submission Information

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Keywords

  • peptides
  • drug delivery
  • endocytosis
  • intercellular transport
  • biomarkers
  • diagnosis
  • therapeutics

Published Papers (1 paper)

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Review

21 pages, 1844 KiB  
Review
Peptides to Overcome the Limitations of Current Anticancer and Antimicrobial Nanotherapies
by Valentina Del Genio, Rosa Bellavita, Annarita Falanga, Katel Hervé-Aubert, Igor Chourpa and Stefania Galdiero
Pharmaceutics 2022, 14(6), 1235; https://doi.org/10.3390/pharmaceutics14061235 - 10 Jun 2022
Cited by 11 | Viewed by 1975
Abstract
Biomedical research devotes a huge effort to the development of efficient non-viral nanovectors (NV) to improve the effectiveness of standard therapies. NVs should be stable, sustainable and biocompatible and enable controlled and targeted delivery of drugs. With the aim to foster the advancements [...] Read more.
Biomedical research devotes a huge effort to the development of efficient non-viral nanovectors (NV) to improve the effectiveness of standard therapies. NVs should be stable, sustainable and biocompatible and enable controlled and targeted delivery of drugs. With the aim to foster the advancements of such devices, this review reports some recent results applicable to treat two types of pathologies, cancer and microbial infections, aiming to provide guidance in the overall design of personalized nanomedicines and highlight the key role played by peptides in this field. Additionally, future challenges and potential perspectives are illustrated, in the hope of accelerating the translational advances of nanomedicine Full article
(This article belongs to the Special Issue Peptide‐Mediated Targeted Drug Delivery)
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